Design of multiple impeller stirred tanks for the mixing of highly viscous fluids using CFD

Aubin, Joëlle; Xuereb, Catherine

doi:10.1016/j.ces.2005.10.075

Cited by 51 publications

(21 citation statements)

References 6 publications

(8 reference statements)

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“…In some studies flow pattern is analyzed with velocity vectors to show flow direction and velocity field [10] [11] [12]. In Figure 2 the velocity vectors are shown in two horizontal planes, the first at the agitator's level and the second at the tank surface.…”

Section: Resultsmentioning

confidence: 99%

CFD simulation of mixing process in a large crude oil storage tank with side-entry impellers

Hernández-Jaramillo¹,

Nieto-Londoño²,

Álvarez-Sarmiento³

et al. 2015

Iteckne

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Abstract-This work presents the study of the flow distribution in a crude oil storage tank of 36.5 m of diameter. The tank is equipped with two side-entry impellers placed at 90° and 45° mounting angle. Computational fluid dynamics (CFD) is used to simulate the tank conditions with 7.7 m of filling level. In addition, it is performed a homogenization time analysis of two different crude oils, for the case of mounting angle of 45°. A twophase model (Volume of fluid, VOF) is used to simulate the mixing process. The rotation of the impellers is modeling by Multiple Frames of Reference (MFR). The phenomenon is resolved using the RNG version of the k-ε turbulence model. Keywords-Side entry impeller, mixing, storage tank, computational fluid dynamics.

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Section: Resultsmentioning

confidence: 99%

CFD simulation of mixing process in a large crude oil storage tank with side-entry impellers

Hernández-Jaramillo¹,

Nieto-Londoño²,

Álvarez-Sarmiento³

et al. 2015

Iteckne

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“…CFD modeling studies conducted during process development stage can help in assessing the risk to process performance as a result of such variations in material attributes and help minimize potential issues during manufacture. Aubin et al [42] have shown how design changes may be implemented on current mixers to improve performance or better mixers designed using CFD modeling. The authors have shown that by one of the Intermig impellers by 45°relative to its neighbors, instead of 90°, as recommended by the mixer manufacturer, a wider range of operating conditions may be handled.…”

Section: Application Of Modeling Approaches For Biologic Drug Productmentioning

confidence: 99%

Application of Mechanistic Models for Process Design and Development of Biologic Drug Products

Chen

Gandhi

et al. 2016

J Pharm Innov

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Modeling approaches play a valuable role at various stages of development and life-cycle management of biopharmaceutical products. In Quality-by-Design (QbD) paradigm, quality needs to be designed into the product rather than merely confirming it through end product testing; this requires in-depth understanding of the product quality and impact of manufacturing process on product quality (Group IEW 2005. Modeling strategies in support of QbD paradigm for biologics are particularly important because of the costs involved in the development of biologic products (Group CBW 2009; Fissore and Antonello (Qual Des Biopharm Drug Prod Dev 18:565-93, 2015)). This mini-review focuses on the application of mechanistic models in the development of biologic drug products as ready-to-use solutions or lyophilized drug products. The choice of the modeling approach is dependent on the specific processes involved in the unit operation as well as intent of application of modeling. The application of models to unit operations in biologics drug product processing such as mixing (compounding), membrane transfer (ultrafiltration/diafiltration), freeze-thaw, and lyophilization, to characterize the quality risks, define the design space, provide input to control strategy, and build robustness in the process will be discussed.

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“…A CFD study on the laminar flow and mixing performance in a tank stirred by four Intermig impellers was carried out by Aubin and Xuereb [12]. They investigated the effect of multiple Intermig impeller configuration on mixing performance in a stirred tank.…”

Section: Introductionmentioning

confidence: 99%

Experimental and computational fluid dynamic (CFD) studies on mixing characteristics of a modified helical ribbon impeller

Rahimi

Kakekhani

Alsairafi

2010

Korean J. Chem. Eng.

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Experimental and computational fluid dynamic (CFD) modeling studies have been performed on mixing characteristics of a new modified helical ribbon impeller in a viscous medium. A novel arrangement for the multiple reference frame (MRF) technique was proposed and the modeling results were compared with those of conventional MRF selecting method. Calculations were performed to study the effects of several parameters: axial flow number, axial circulation time, impeller clearance, and power consumption. The higher performance of the modified impeller has been proven in terms of axial flow number and axial circulation time. The results showed that significant improvement in mixing performance can be obtained at a higher impeller clearance with the modified impeller employed. In addition, the power consumption by the new impeller has been compared with that of the classic one. The CFDpredicted flow patterns generated by the impellers were used to explain the higher performance of the modified impeller. In addition, the results reveal that the CFD-predicted particle volume fractions at various axial distances from the tank bottom are reasonably in agreement with the experimental observations.

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Design of multiple impeller stirred tanks for the mixing of highly viscous fluids using CFD

Cited by 51 publications

References 6 publications

CFD simulation of mixing process in a large crude oil storage tank with side-entry impellers

CFD simulation of mixing process in a large crude oil storage tank with side-entry impellers

Application of Mechanistic Models for Process Design and Development of Biologic Drug Products

Experimental and computational fluid dynamic (CFD) studies on mixing characteristics of a modified helical ribbon impeller

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