Abstract:To design D-amino acid dehydrogenase (DAADH) for enhanced stability, the
interactions of the subunit interfaces of DAADH were analyzed.
Interaction network analysis of DAADH indicated that there are only weak
interactions between the A and B subunits. Several co-evolved residue
pairs were selected for mutation to enhance interfacial interactions of
subunits, and 11 designed MDHs were obtained. DA06 and DA11 were
selected for experimental verification for their salt bridges are 1.4
and 1.2-fold of that of DAwil… Show more
Set email alert for when this publication receives citations?
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.