Design of hydroxyapatite bioceramics with micro-/nano-topographies to regulate the osteogenic activities of bone morphogenetic protein-2 and bone marrow stromal cells

Li, Xiangfeng; Liu, Minjun; Chen, Fuying; Wang, Yuyi; Wang, Menglu; Chen, Xuening; Xiao, Yumei; Zhang, Xingdong

doi:10.1039/c9nr10561a

Cited by 37 publications

(19 citation statements)

References 62 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Calcium phosphate ceramic is considered as the most promising bone substitute material because of its high osteoinduction potential [ [26] , [27] , [28] , [29] ]. Lots of studies from our group and other groups have proved that the process of cell, cell differentiation and osteogenesis during bone induction of calcium phosphate ceramics is consistent with the process of natural bone regeneration or reconstruction [ 9 , 30 , 31 ]. However, up to now, there has been no report on synthetic biomaterial that can successfully regenerative repair large segmental load-bearing bone defects without using exogenous active factors or cells.…”

Section: Discussionmentioning

confidence: 98%

Optimal regenerative repair of large segmental bone defect in a goat model with osteoinductive calcium phosphate bioceramic implants

Zhi

Xiao-hua

Sun

et al. 2022

Bioactive Materials

Self Cite

View full text Add to dashboard Cite

So far, how to achieve the optimal regenerative repair of large load-bearing bone defects using artificial bone grafts is a huge challenge in clinic. In this study, a strategy of combining osteoinductive biphasic calcium phosphate (BCP) bioceramic scaffolds with intramedullary nail fixation for creating stable osteogenic microenvironment was applied to repair large segmental bone defects (3.0 cm in length) in goat femur model. The material characterization results showed that the BCP scaffold had the initial compressive strength of over 2.0 MPa, and total porosity of 84%. The cell culture experiments demonstrated that the scaffold had the excellent ability to promote the proliferation and osteogenic differentiation of rat bone marrow-derived mesenchymal stem cells (BMSCs). The in vivo results showed that the intramedullary nail fixation maintained the initial stability and structural integrity of the implants at early stage, promoting the osteogenic process both guided and induced by the BCP scaffolds. At 9 months postoperatively, good integration between the implants and host bone was observed, and a large amount of newborn bones formed, accompanying with the degradation of the material. At 18 months postoperatively, almost the complete new bone substitution in the defect area was achieved. The maximum bending strength of the repaired bone defects reached to the 100% of normal femur at 18 months post-surgery. Our results demonstrated the good potential of osteoinductive BCP bioceramics in the regenerative repair of large load-bearing bone defects. The current study could provide an effective method to treat the clinical large segmental bone defects.

show abstract

Section: Discussionmentioning

confidence: 98%

Optimal regenerative repair of large segmental bone defect in a goat model with osteoinductive calcium phosphate bioceramic implants

Zhi

Xiao-hua

Sun

et al. 2022

Bioactive Materials

Self Cite

View full text Add to dashboard Cite

show abstract

“…Extensive studies have considered the bone‐like apatite formation on the surface of Ca‐P bioceramics as a prerequisite for osteoinductivity, and thus the ability of bone‐like apatite formation has become a direct criterion to evaluate the bioactivity and osteoinductive potential of new biomaterials 49‐51 . This study demonstrated that all the four kinds of BCP ceramics processed good bone‐like apatite forming abilities (Figure 9).…”

Section: Discussionmentioning

confidence: 85%

Enhancing mechanical and biological properties of biphasic calcium phosphate ceramics by adding calcium oxide

Wang

Chen

et al. 2020

J. Am. Ceram. Soc.

Self Cite

View full text Add to dashboard Cite

Biomaterials can induce the regeneration of damaged tissue through the optimized design of the materials themselves, which is important to the development of regenerative medicine. 1-3 Calcium phosphate (Ca-P) ceramics are widely believed as excellent bone grafts, in consideration of their good biocompatibility, bioactivity, and osteoconductivity. 4-6 Among them, biphasic calcium phosphate (BCP) ceramic seems to be one of the best choices, due to its suitable solubility and excellent osteoinductivity. 7-9 However, traditional BCP ceramics are facing many challenges to meet the requirements of regenerative medicine. For instance, BCP ceramics still have relatively low biological properties as comparing compared to natural bones. 10,11 Further mimicking the bony composition and structure to enhance the bioactivity of BCP ceramics seems necessary and significative. In addition, the brittleness and low resistance to fracture of BCP ceramics limit their applications in non-load-bearing bone defect filling, and thus the

show abstract

“…Our previous studies have certified that the osteoinductivity of BCP ceramics could be heightened by the design of nano-topography. [38][39][40] However, to achieve the simultaneous enhancements of mechanical properties and biological performances of Ca-P ceramics has not achieved right now. Therefore, the present study attempted to solve the paradox by constructing the in-situ whisker on BCP ceramics.…”

Section: Discussionmentioning

confidence: 99%

Effect of Hydrothermal Media on the in-situ Whisker Growth on Biphasic Calcium Phosphate Ceramics

Feng

Cao

et al. 2021

IJN

Self Cite

View full text Add to dashboard Cite

Design of hydroxyapatite bioceramics with micro-/nano-topographies to regulate the osteogenic activities of bone morphogenetic protein-2 and bone marrow stromal cells

Abstract: Biomimicking the nanostructure of natural bone apatite to enhance the bioactivity of hydroxyapatite (HA) biomaterials is an eternal topic in the bone regeneration field.

Cited by 37 publications

References 62 publications

Optimal regenerative repair of large segmental bone defect in a goat model with osteoinductive calcium phosphate bioceramic implants

Optimal regenerative repair of large segmental bone defect in a goat model with osteoinductive calcium phosphate bioceramic implants

Enhancing mechanical and biological properties of biphasic calcium phosphate ceramics by adding calcium oxide

Effect of Hydrothermal Media on the in-situ Whisker Growth on Biphasic Calcium Phosphate Ceramics

Contact Info

Product

Resources

About