Design of Fe–Mn–Ag Alloys as Potential Candidates for Biodegradable Metals

Liu, Ruoyu; He, Rangan; Xu, Liqun; Guo, Shuyu

doi:10.1007/s40195-018-0702-z

Cited by 41 publications

(40 citation statements)

References 31 publications

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“…As manganese shifts the free corrosion potential to the less noble values, alloying with iron increases the corrosion rate [40]. Silver addition was found to form Ag-rich particles within the Fe-Mn matrix that gives a microgalvanic effect thus accelerating corrosion [15,16].…”

Section: Accepted Manuscriptmentioning

confidence: 99%

“…However, the shallow depth of ion implantation (~60 nm) only provided those desirable effects on the thin surface and for a short period. Liu et al [15] developed a Fe-30Mn-1Ag alloy using a rapid solidification technique and found that the alloy corroded faster in simulated body fluid due to the microgalvanic effect of the Ag-rich particles with the Fe-Mn matrix. Similar microgalvanic effect of silver addition to accelerating corrosion was observed by Wiesner et al [16] on Fe-Mn-Ag alloys prepared by selective laser melting from mixed powders of Fe-Mn and Ag.…”

Section: Introductionmentioning

confidence: 99%

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Design and characterization of nano and bimodal structured biodegradable Fe-Mn-Ag alloy with accelerated corrosion rate

Bagha

Khakbiz

Sheibani

et al. 2018

Journal of Alloys and Compounds

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Researchers in biodegradable metals have been putting efforts to accelerate the corrosion of ironbased biodegradable metals. These include by alloying iron with manganese and noble elements such as silver, but further increase to the corrosion rate is still needed. In this study, a set of bimodal nano/microstructured Fe-30Mn-1Ag alloys was prepared through mechanical alloying and spark plasma sintering. The alloys were characterized and tested for their corrosion behavior in Hanks' solution at 37 o C and for their mechanical properties. The bimodal-structured alloy possessed a mixture of austenitic (γ-FeMn) and ferritic (α-Fe) phases, while the nano-and macro-structured ones were essentially composed of γ-FeMn and α-Fe phases, respectively. Addition of 1-3 wt.% of silver into the nanostructured alloy increased its corrosion rate from 0.24 mm/year to 0.33 and 0.58 mm/year for Fe-30Mn-1Ag and Fe-30Mn-3Ag, respectively. Whilst, the bimodal Fe-30Mn-1Ag alloy corroded at a higher rate of 0.88 mm/year. This alloy also possessed an interesting combination of high and low micro-hardness phases that contributed to high shear strength of 417 MPa and shear strain of 0.66. Detailed discussion on the relationship of microstructure with corrosion behavior and mechanical properties is presented in this manuscript.

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Section: Accepted Manuscriptmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Design and characterization of nano and bimodal structured biodegradable Fe-Mn-Ag alloy with accelerated corrosion rate

Bagha

Khakbiz

Sheibani

et al. 2018

Journal of Alloys and Compounds

View full text Add to dashboard Cite

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“…Several authors have focused on increasing the corrosion rate of pure iron by alloying [3, 7, 10] and the creation of microgalvanic couples through the use of noble elements [11, 12]. Addition of Mn to Fe has the effect of reducing the overall corrosion resistance of the alloy when exposed to in vitro solutions which simulate the in vivo scenario [3, 7, 10].…”

Section: Introductionmentioning

confidence: 99%

“…[13] show that pure iron had a corrosion rate of 14 μA/cm 2 in modified Hank's solution and this rose to 105.6 μA/cm 2 in the same electrolyte when 35% Mn was added to the sample composition. The addition of cathodic elements such as palladium and silver increases the corrosion rate of pressed and sintered iron based alloys, and this increase is attributed mainly to the galvanic effect of the cathodic element inclusions on the Fe–Mn grains [11, 12]. However, it is observed that with palladium, the increase in corrosion was not accompanied by an increase in the mass of material lost from the alloy.…”

Section: Introductionmentioning

confidence: 99%

The effect of alloying elements on the properties of pressed and non-pressed biodegradable Fe–Mn–Ag powder metallurgy alloys

Conti

Mallia

Sinagra

et al. 2019

Heliyon

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Current trends in the biodegradable scaffold industry call for powder metallurgy methods in which compression cannot be applied due to the nature of the scaffold template itself and the need to retain the shape of an underlying template throughout the fabrication process. Iron alloys have been shown to be good candidates for biomedical applications where load support is required. Fe–Mn alloys were researched extensively for this purpose. Current research shows that all metallurgical characterisation and corrosion test on Fe–Mn and Fe–Mn–Ag non pre-alloyed powder alloys are performed on alloys which are initially pressed into greens and subsequently sintered. In order to combine the cutting-edge field of biodegradable metallic alloys with scaffold production, metallurgical characterisation of pressed and non-pressed Fe, Fe–Mn and Fe–Mn–Ag sintered elemental powder compacts was carried out in this study. This was performed along with determination of the corrosion rate of the same alloys in in vitro mimicking solutions. These solutions were synthesised to mimic the osteo environment in which the final scaffolds are to be used.Both pressed and non-pressed alloys formed an austenite phase under the right sintering conditions. The corrosion rate of the non-pressed alloy was greater than that of its pressed counterpart. In a potentiodynamic testing scenario, addition of silver to the alloy formed a separate silver phase which galvanically increased the corrosion rate of the pressed alloy. This result wasn't replicated in the non-pressed alloys in which the corrosion rate was seen to remain similar to the non-silver-bearing alloy counterparts.

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“…Since the beginning of the twenty-first century, biodegradable metals represent a new generation of biomedical materials used as temporary implants in vascular intervention or osteosynthesis [1,2]. These novel biodegradable metals have revolutionized the traditional idea of permanent devices, avoiding persistent physical irritation, chronic inflammation, the need for prolonged anti-platelet aggregation therapy, and possible surgery for removing the implant [3].…”

Section: Introductionmentioning

confidence: 99%

Mind your assays: Misleading cytotoxicity with the WST-1 assay in the presence of manganese

et al. 2020

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The WST-1 assay is the most common test to assess the in vitro cytotoxicity of chemicals. Tetrazolium-based assays can, however, be affected by the interference of tested chemicals, including carbon nanotubes or Mg particles. Here, we report a new interference of Mn materials with the WST-1 assay. Endothelial cells exposed to Mn particles (Mn alone or Fe-Mn alloy from 50 to 1600 μg/ml) were severely damaged according to the WST-1 assay, but not the ATP content assay. Subsequent experiments revealed that Mn particles interfere with the reduction of the tetrazolium salt to formazan. Therefore, the WST-1 assay is not suitable to evaluate the in vitro cytotoxicity of Mn-containing materials, and luminescencebased assays such as CellTiter-Glo ® appear more appropriate.

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Design of Fe–Mn–Ag Alloys as Potential Candidates for Biodegradable Metals

Cited by 41 publications

References 31 publications

Design and characterization of nano and bimodal structured biodegradable Fe-Mn-Ag alloy with accelerated corrosion rate

Design and characterization of nano and bimodal structured biodegradable Fe-Mn-Ag alloy with accelerated corrosion rate

The effect of alloying elements on the properties of pressed and non-pressed biodegradable Fe–Mn–Ag powder metallurgy alloys

Mind your assays: Misleading cytotoxicity with the WST-1 assay in the presence of manganese

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