Design Of DC-Dielectrophoresis Microfluidic Channel For Particle and Biological Cell Separation Using 3D Printed PVA Material

Teoh, Boon Yew; Lee, Poh Fong; Thong, Yi Leng; Lim, Yang Mooi

doi:10.1109/iecbes.2018.8626636

Cited by 2 publications

(1 citation statement)

References 8 publications

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“…These devices present great potential for bioparticle manipulation, although their throughput might be further improved. Additionally, new materials such as carbon electrodes, − liquid metal electrodes, along with new manufacturing methods such as screen-printing, and three-dimensional (3D) printing, − may be developed to further improve the performance of DEP techniques; because the PDMS or glass used for making nearly all the devices reported so far can limit the integration of the electrodes.…”

Section: Outlook and Summarymentioning

confidence: 99%

Methods of Generating Dielectrophoretic Force for Microfluidic Manipulation of Bioparticles

Kwizera

Sun

White

et al. 2021

ACS Biomater. Sci. Eng.

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Manipulation of microscale bioparticles including living cells is of great significance to the broad bioengineering and biotechnology fields. Dielectrophoresis (DEP), which is defined as the interactions between dielectric particles and the electric field, is one of the most widely used techniques for the manipulation of bioparticles including cell separation, sorting, and trapping. Bioparticles experience a DEP force if they have a different polarization from the surrounding media in an electric field that is nonuniform in terms of the intensity and/or phase of the electric field. A comprehensive literature survey shows that the DEP-based microfluidic devices for manipulating bioparticles can be categorized according to the methods of creating the nonuniformity via patterned microchannels, electrodes, and media to generate the DEP force. These methods together with the theory of DEP force generation are described in this review, to provide a summary of the methods and materials that have been used to manipulate various bioparticles for various specific biological outcomes. Further developments of DEP-based technologies include identifying materials that better integrate with electrodes than current popular materials (silicone/glass) and improving the performance of DEP manipulation of bioparticles by combining it with other methods of handling bioparticles. Collectively, DEP-based microfluidic manipulation of bioparticles holds great potential for various biomedical applications.

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Section: Outlook and Summarymentioning

confidence: 99%

Methods of Generating Dielectrophoretic Force for Microfluidic Manipulation of Bioparticles

Kwizera

Sun

White

et al. 2021

ACS Biomater. Sci. Eng.

View full text Add to dashboard Cite

show abstract

Novel Approaches Concerning the Numerical Modeling of Particle and Cell Separation in Microchannels: A Review

Karampelas¹,

Gómez-Pastora

2022

Processes

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The demand for precise separation of particles, cells, and other biological matter has significantly increased in recent years, leading to heightened scientific interest in this topic. More recently, due to advances in computational techniques and hardware, numerical simulations have been used to guide the design of separation devices. In this article, we establish the theoretical basis governing fluid flow and particle separation and then summarize the computational work performed in the field of particle and cell separation in the last five years with an emphasis on magnetic, dielectric, and acoustic methods. Nearly 70 articles are being reviewed and categorized depending on the type of material separated, fluid medium, software used, and experimental validation, with a brief description of some of the most notable results. Finally, further conclusions, future guidelines, and suggestions for potential improvement are highlighted.

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Design Of DC-Dielectrophoresis Microfluidic Channel For Particle and Biological Cell Separation Using 3D Printed PVA Material

Cited by 2 publications

References 8 publications

Methods of Generating Dielectrophoretic Force for Microfluidic Manipulation of Bioparticles

Methods of Generating Dielectrophoretic Force for Microfluidic Manipulation of Bioparticles

Novel Approaches Concerning the Numerical Modeling of Particle and Cell Separation in Microchannels: A Review

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