Design of carbon dots as nanozymes to mediate redox biological processes

Abstract

Nanozymes are new type of artificial enzymes based on engineering nanomaterials, which have developed to understand and mimic natural enzymes for making better catalytic materials, understanding structure-function relationship and utilizing...

Natural Enzyme-Inspired Design of the Single-Atom Cu Nanozyme as Dual-Enzyme Mimics for Distinguishing Total Antioxidant Capacity and the Ascorbic Acid Level

“…Nanozymes, as one kind of nanomaterial which is artificially designed to simulate the function of natural enzymes, have aroused high attention for their unparalleled advantages, for example, high activity and stability, , low production costs, and easy modification. , Among them, peroxidase (POD) and oxidase (OXD)-mimic nanozymes have been most widely explored due to the widespread existence of these activities in many nanomaterials, such as transition metal-based, − precious metal-based, − and carbon-based materials. − Nevertheless, poor substrate selectivity hinders their widespread application. Nanozymes that use specific biomolecules as substrates are seldomly reported, , especially ascorbic acid oxidase (AAO) mimetic nanozymes with ascorbic acid (AA) as the substrate.…”

Copper-Bearing Metal-Organic Framework with Mucus-Penetrating Function for the Multi-Effective Clearance of Mucosal Colonized Helicobacter pylori

“…(c) Scavenging ROS and regulating inflammatory response. Recent studies have shown that carbon dots can effectively eliminate intracellular ROS and have excellent antioxidant activity [ 18 – 20 ]. Nitrogen, which has the advantages of small atomic weight, safety, economy, environmental friendliness, and low toxicity, is chosen as the heteroatom.…”

Light-activated carbon dot nanozyme with scandium for a highly efficient and pH-universal bio-nanozyme cascade colorimetric assay

“…Compared with normal peroxide- and oxide-mimicking enzymes, light-activated nanozymes are more suitable for the construction of catalytic cascades due to several advantages, such as their light-regulated activity, the use of oxygen as a green oxidant, and their often higher activity, 25–29 and structure-specific light-responsive nanozymes can be used to enhance the substrate specificity. 30 Carbon nanomaterials have been used widely as enzyme-like nanozymes due to their low cost, easy synthesis and stable properties, 31 e.g. , Ru-deposited C 3 N 4 for the quantification of electrochemically accumulated H 2 O 2 .…”