Design of biocompatible and biodegradable polymers based on intermediate water concept

Tanaka, Masaru; Sato, Kazuhiro; Kitakami, Erika; Kobayashi, Shū; Hoshiba, Takashi; Fukushima, Kazuki

doi:10.1038/pj.2014.129

Cited by 138 publications

(128 citation statements)

References 88 publications

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“…PMEA is chosen due to its FDA approval in medical devices and applications. 22 The inherent freezing bound water bestows excellent blood compatibility to the intermediately hydrophilic PMEA 22 , and allows its exploitation as coating material for circuits and tubes in cardiopulmonary bypass and catheters for central veins of blood vessels 22 as well as for artificial oxygenators. 23 MEA has been employed as one of the building blocks in preparation of random, 24 block, 25,26 and graft copolymers 27,28 by means of controlled radical polymerizations.…”

Section: Introductionmentioning

confidence: 99%

Linear Viscoelastic and Dielectric Relaxation Response of Unentangled UPy-Based Supramolecular Networks

et al. 2016

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Supramolecular polymers possess versatile mechanical properties and a unique ability to respond to external stimuli. Understanding the rich dynamics of such associative polymers is essential for tailoring user defined properties in many products. Linear copolymers of 2-methoxyethyl acrylate (MEA) and varying amounts of 2-ureido-4[1H]-pyrimidone (UPy) quadruple hydrogen-bonding side units were synthesized via free radical polymerization. Their linear viscoelastic response was studied via small amplitude oscillatory shear (SAOS). The measured linear viscoelastic envelope (LVE) resembles that of a well entangled polymer melt with a distinct * To whom correspondence should be addressed † Technical University of Denmark ‡ University of the Basque Country ¶ Drexel University 1 plateau modulus. Dielectric relaxation spectroscopy (DRS) was employed to independently examine the lifetime of hydrogen bond units. DRS reveals a high frequency α-relaxation associated with the dynamic glass transition, followed by a slower α * -relaxation attributed to the reversible UPy hydrogen bonds. This timescale is referred to as the bare lifetime of hydrogen bonding units. Using the sticky Rouse model and a renormalized lifetime, we predict satisfactorily the LVE response for varying amounts of UPy side groups. The deviation from the sticky Rouse prediction is attributed to polydispersity in the distribution of UPy groups along the chain backbone. We conclude that the response of associating polymers in linear viscoelasticity is general and does not depend on the chemistry of association, but rather on the polymer molecular weight (MW) and MW distribution, the number of stickers per chain, n s , and the distribution of stickers along the backbone.

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Section: Introductionmentioning

confidence: 99%

Linear Viscoelastic and Dielectric Relaxation Response of Unentangled UPy-Based Supramolecular Networks

et al. 2016

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“…26 As an alternative for natural ECM components, various biodegradable and biocompatible synthetic polymers can be used to develop scaffolds for co-cultures, such as polycaprolactone (PCL), poly(l-lactic acid) (PLA), poly(glycolic acid) (PGA), and poly(lacticco-glycolic) acid (PLGA). 27 Although these synthetic materials are able to mimic the physical properties of ECM to some extent, they need to be further functionalized to create a more favorable environment for the cells. Combinations of synthetic polymers with naturally derived ECM can be used to fabricate an appropriate matrix for pre-vascularization approaches.…”

Section: Selection Of Appropriate Matrix or Scaffoldmentioning

confidence: 99%

Mesenchymal stem cells for pre-vascularization of engineered tissues

Zhao¹

2018

JSRT

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Engineered tissues with a thickness larger than 150μm require an embedded functional vascular network to support cell survival and integration with host vasculature after in vivo implantation. Mesenchymal stem cells (MSCs) can secrete trophic factors to promote angiogenesis and function as pericytes to stabilize endothelial cell engineered neo-capillary structures. Recently, studies have shown that co-culturing MSCs with endothelial cells (ECs) could develop a pre-capillary network in tissue scaffolds. To realize such an outcome, several factors need to be considered, including MSC source, cell seeding order, oxygen concentration, and extra cellular matrix features. The present mini review summarizes these crucial considerations and will provide beneficial references for successful development of functional pre-vascularized tissues.

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“…It has always been difficult to engineer polymers or polymeric compositions for stomach specific drug delivery [1][2][3]. The engineered polymeric compositions should have attributes that are pertinent to high level of gastric retention, generally 5-6 h [4,5], release the drug at zero-order or at a constant rate [6,7], and degrade in vivo to smaller fragments, which can then be excreted from the body; their degradation products must be nontoxic and not create an inflammatory response; and finally, they should degrade within a reasonable period of time [1,2]. Although polymers of various origins are available and used in drug delivery systems, natural polysaccharides find much application because of their favorable characteristics like abundant availability, inexpensive, nontoxic, noncarcinogenic, and biodegradable, and more importantly biocompatibility.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Chitosan Based Polymeric Matrices for Sustained Stomach Specific Delivery of Propranolol Hydrochloride

Dubey

Verma

2015

Indian Journal of Materials Science

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The objective of the present investigation was to explore the potential of Chitosan based polymeric matrices as carrier for sustained stomach specific delivery of model drug Propranolol Hydrochloride. Briefly, single unit hydrodynamically balanced (HBS) capsule formulations were prepared by encapsulating in hard gelatin capsules, intimately mixed physical mixtures of drug, and cationic low molecular weight Chitosan (LMCH) in combination with either anionic medium viscosity sodium alginate (MSA) or sodium carboxymethylcellulose (CMCNa). The effect of incorporation of nonionic polymers, namely, tamarind seed gum (TSG) and microcrystalline cellulose (MCCP), was also investigated. It was observed that HBS formulations remained buoyant for up to 6 h in 0.1 M HCl, when LMCH : anionic/nonionic polymer ratio was at least 4 : 1. It was also observed that LMCH has formed polyelectrolyte complex (PEC) with MSA (4 : 1.5 ratio) and CMCNa (4 : 1 ratio) in situ during the gelation of HBS formulations in 0.1 M HCl. The retardation in drug release was attributed to the PEC formation between LMCH and MSA/CMCNa. Incorporation of MCCP (rapid gel formation) and TSG (Plug formation) was found to be innovative. From the data, it is suggested that Chitosan based polymeric matrices may constitute an excellent carrier for stomach specific drug delivery.

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Design of biocompatible and biodegradable polymers based on intermediate water concept

Cited by 138 publications

References 88 publications

Linear Viscoelastic and Dielectric Relaxation Response of Unentangled UPy-Based Supramolecular Networks

Linear Viscoelastic and Dielectric Relaxation Response of Unentangled UPy-Based Supramolecular Networks

Mesenchymal stem cells for pre-vascularization of engineered tissues

Evaluation of Chitosan Based Polymeric Matrices for Sustained Stomach Specific Delivery of Propranolol Hydrochloride

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