Evaluation of Chitosan Based Polymeric Matrices for Sustained Stomach Specific Delivery of Propranolol Hydrochloride

Dubey, Juhi; Verma, Anurag; Verma, Navneet Kumar

doi:10.1155/2015/312934

Cited by 9 publications

(6 citation statements)

References 13 publications

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“…Mucoadhesive ability could result in formulations containing chitosan being retained in the mucosal surface such as gastric mucosa due to the acidic environment of the stomach. Due to the high degree of swelling and mucoadhesive properties in acidic medium, chitosan-based hydrogels have been used as a carrier for stomach—specific drug delivery systems [6,7,8,9,10,11].…”

Section: Introductionmentioning

confidence: 99%

Enhancement of Curcumin Bioavailability Using Nanocellulose Reinforced Chitosan Hydrogel

2017

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A unique biodegradable, superporous, swellable and pH sensitive nanocellulose reinforced chitosan hydrogel with dynamic mechanical properties was prepared for oral administration of curcumin. Curcumin, a less water-soluble drug was used due to the fact that the fast swellable, superporous hydrogel could release a water-insoluble drug to a great extent. CO 2 gas foaming was used to fabricate hydrogel as it eradicates using organic solvents. Field emission scanning electron microscope images revealed that the pore size significantly increased with the formation of widely interconnected porous structure in gas foamed hydrogels. The maximum compression of pure chitosan hydrogel was 25.9 ± 1 kPa and it increased to 38.4 ± 1 kPa with the introduction of 0.5% cellulose nanocrystals. In vitro degradation of hydrogels was found dependent on the swelling ratio and the amount of CNC of the hydrogel. All the hydrogels showed maximum swelling ratios greater than 300%. The 0.5% CNC-chitosan hydrogel showed the highest swelling ratio of 438% ± 11%. FTIR spectrum indicated that there is no interaction between drug and ingredients present in hydrogels. The drug release occurred in non-Fickian (anomalous) manner in simulated gastric medium. The drug release profiles of hydrogels are consistent with the data obtained from the swelling studies. After gas foaming of the hydrogel, the drug loading efficiency increased from 41% ± 2.4% to 50% ± 2.0% and release increased from 0.74 to 1.06 mg/L. The drug release data showed good fitting to Ritger-Peppas model. Moreover, the results revealed that the drug maintained its chemical activity after in vitro release. According to the results of this study, CNC reinforced chitosan hydrogel can be suggested to improve the bioavailability of curcumin for the absorption from stomach and upper intestinal tract.

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Section: Introductionmentioning

confidence: 99%

Enhancement of Curcumin Bioavailability Using Nanocellulose Reinforced Chitosan Hydrogel

2017

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“…The kinetics of drug release from microbeads is essential because they affect the drug bioavailability, dosing intervals, and the occurrence of toxic side effects (Dubey et al, 2015). The results of kinetic modeling for the release of metronidazole from the microbeads are shown in Table 5.…”

Section: Fig 4 Drug Release Profiles Of Metronidazole Floating Microbeads Prepared Using Polymer Mixtures Containing Different Concentratmentioning

confidence: 99%

“…The release rate constant in Korsmeyer-Peppas model considers the structural and the geometric characteristics of pharmaceutical formulations. In addition, the Korsmeyer-Peppas model also gives an insight into the type of drug release mechanism occurring from swellable polymeric devices(Dubey et al, 2015). It therefore encompasses the component, n, which is the diffusional exponent or release exponent, indicative of the drug release mechanism.…”

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confidence: 99%

Formulation of floating metronidazole microbeads using Terminalia mantaly gum as polymer

Ajala

Moshood

Odeku

2021

British Journal of Pharmacy

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The aim of the present study was to evaluate Terminalia mantaly gum as a polymer in the formulation of floating metronidazole microbeads. Terminalia gum was extracted and characterized using mateial, proximate and pasting properties. Terminalia gum in combination with sodium alginate at varying conccentrations (0-80 %w/w)was used in preparing the microbeads by ionotropic gelation using zinc chloride as the chelating agent. The microbeads were evaluated using shape, size, swelling, bouyancy, entrapment efficiency, drug release profiles and kinetic modelling. The microbeads were spherical to ovoid in shape with sizes ranginf from 1093 to 1209 micrometer. The swelling index was 5 to 184 % and it increased with increase in gum concentration. The total floating time was highest (175.5 h) for formulations having 20 %w/w gum and least (5.5 h) for those with 80 %w/w gum. The entrapment efficiency generally increased with increase in gum concentration up to 40 % and then reduced. The microbeads showed controlled release patterns of metronidazole with least t80 greaer than 5.8h. The drug release kinetics fitted Korsmeyer-Peppas model with non-Fickian anomalous diffusion mechanism. Terminalia mantaly gum can be further developed for use as co-polymer in the formulation of floating metronidazole microbeads.

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“…As a result, hydrogel lost its integrity and became distorted, leading to burst release and premature sinking of the formulation. [26] Considering the observation, in the present study, to improve the buoyancy and to address the problem of burst release, we have decided to coat the capsule formulations (R1, R2, and R3) with molten gelucire 43/01.…”

Section: In Vitro Buoyancy and Drug Release Studiesmentioning

confidence: 99%

Carboxymethylation of Karaya gum: application in gastroretentive drug delivery for sustained release of model drug

Verma

Sachan

Verma

2020

Int. J. Pharm. Sci. Drug Res.

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Karaya gum (KG) is one of the least soluble of the gums. It does not dissolve in water to give a clear solution but instead absorbs water rapidly to form viscous colloidal sols. Carboxymethylation of Karaya gum is expected to improve its aqueous solubility and gelling behavior. Another objective of the research is to evaluate the potential of carboxymethylated Karaya gum (CMKG) as drug release modulator (in acidic dissolution medium) when combined with HPMC K15M based polymeric matrices bearing Propranolol HCl. In the present study, KG was carboxymethylated using Williamson Ether synthesis. FTIR spectroscopy confirmed the formation of CMKG. The prepared CMKG was used in conjunction with HPMC K15M as a polymer matrix in the formulation capsule dosage form, using Propranolol HCl as model drug. The filled capsules were then coated with Gelucire 43/01 to convert them into hydrodynamically balanced (HBS) capsule dosage form. Dextrose & fructose were also added to the drug-polymer mix as osmogen to facilitate the drug release. The degree of substitution of CMKG was found to be 0.87. HBS capsule dosage forms remained buoyant on 0.1 HCl for up to 6 hr, the buoyancy was attributed to the Gelucire 43/01 coating around the capsule shell. From the experimentation it was observed that CMKG, when mixed with HPMC K15M at 1:3 ratios, extended the release of model drug from HBS capsule dosage forms in 0.1 HCl. At CMKG: HPMC K15M ratio 2:1, release of Propranolol Hydrochloride from hydrodynamically balanced (HBS) capsules revealed fast drug release in 0.1 HCl. From the observations it is evident that KG is amenable to carboxymethylation to form CMKG. It is also evident that it is advantageous to combine CMKG with HPMC K15M as release modulator to retard the release of Propranolol HCl in acidic dissolution medium.

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Evaluation of Chitosan Based Polymeric Matrices for Sustained Stomach Specific Delivery of Propranolol Hydrochloride

Cited by 9 publications

References 13 publications

Enhancement of Curcumin Bioavailability Using Nanocellulose Reinforced Chitosan Hydrogel

Enhancement of Curcumin Bioavailability Using Nanocellulose Reinforced Chitosan Hydrogel

Formulation of floating metronidazole microbeads using Terminalia mantaly gum as polymer

Carboxymethylation of Karaya gum: application in gastroretentive drug delivery for sustained release of model drug

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