This research is concerned with a multiple loop antenna applicable to near field ultra-high frequency (UHF) radio frequency identification (RFID). The proposed multi-loop antenna is configured to induce the robust and even magnetic field distributions in the H x , H y , and H z orientations so as to achieve the enhanced readability performances in all directions (i.e., x, y, and z). Simulations were carried out using CST Microwave Studio to determine the impedance bandwidth (|S 11 |<210 dB) in the frequency range of 920-925 MHz (i.e., Thailand's UHF RFID standard) and to investigate the H x -, H y -, and H z -oriented magnetic field distributions. A prototype antenna of 14 cm 3 16 cm 3 0.6 mm (W 3 L 3 H) in overall dimension was subsequently fabricated on an FR4 substrate connected to a coaxial cable. In this research, the H x -, H y -, and H z -oriented magnetic field distributions of the prototype antenna were measured in the x-axis, y-axis, and x-y plane and are in good agreement with the simulation results. The measured readability performances in the x-, y-, and z-directions in which seven near field UHF RFID tags were deployed unobstructed (i.e., in open air) are respectively 25.27%, 31.73%, and 85.43%. Furthermore, the performances on the antenna readability with the tags attached to the microcentrifuge tubes are 30.55%, 25.90%, and 69.09% for the x-, y-, and z-directions. V C 2016 Wiley Periodicals, Inc. Int J RF and Microwave CAE 26:402-417, 2016.