Design of a nanocomposite with gold nanoparticles as the core and casein-templated gold nanoclusters as the shell with ultra-low protein corona for enhanced photodynamic therapy

Zhang, Yue; Huang, Yuan; Chen, Hao; Li, Xinxin; Zhang, Jinzhi; Wang, Hang‐Xing; Zou, Qichao; Wang, Suxiao

doi:10.1039/d2ma00481j

Cited by 2 publications

(1 citation statement)

References 40 publications

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“…However, most traditional PSs (dyes) are extremely insoluble, are hydrophobic, and have low stability, which leads to the limited efficiency of PDT . To overcome these difficulties, researchers have investigated the use of photosensitizing nanoparticles alone and in conjunction with other PSs. − Moreover, nanoparticles are known to have unique optical properties that make them highly efficient at absorbing light, and as a result, they can generate more ROS than traditional dyes. This is due to their small size and large surface area, which allow for more interactions with light and a higher degree of energy transfer .…”

Section: Light-activated Antimicrobial Nanoparticle–polymer Compositesmentioning

confidence: 99%

Review of Light-Activated Antimicrobial Nanoparticle–Polymer Composites for Biomedical Devices

Omidiyan,

Srinoi,

Tajalli

et al. 2024

ACS Appl. Nano Mater.

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Nosocomial infections are a significant threat to public health that leads to substantial morbidity and mortality. The emergence and spread of antibiotic-resistant organisms have compounded the complexity of managing these infections, highlighting the urgent need for innovative and effective strategies to combat them. Photostimuli-responsive nanomaterials have emerged as promising tools for coating biomedical devices and tools against nosocomial infections due to their ability to selectively target and kill pathogenic bacteria and fungi. It is feasible to develop antibacterial surfaces by integrating photothermal agents (PTAs), photodynamic agents (PDAs), and both PTAs and PDAs into coatings. When exposed to light, PTAs generate heat that can be used to kill bacteria, while PDAs emit reactive oxygen species (ROS) that can also be used to kill bacteria. The combination of photothermal and photodynamic therapies produces a synergistic effect in which the death of bacteria is boosted in comparison with the use of each individual therapy. These coatings have the potential to provide enhanced bacterial control for a number of biomedical devices, including implants, catheters, meshes, and wound dressings. The utilization of antimicrobial nanomaterials offers a promising approach for reducing the risk of infections associated with the use of these devices.

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Section: Light-activated Antimicrobial Nanoparticle–polymer Compositesmentioning

confidence: 99%

Review of Light-Activated Antimicrobial Nanoparticle–Polymer Composites for Biomedical Devices

Omidiyan,

Srinoi,

Tajalli

et al. 2024

ACS Appl. Nano Mater.

View full text Add to dashboard Cite

show abstract

Tailoring gold nanocluster properties for biomedical applications: From sensing to bioimaging and theranostics

Mussa Farkhani,

Dehghankelishadi,

Refaat

et al. 2024

Progress in Materials Science

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Design of a nanocomposite with gold nanoparticles as the core and casein-templated gold nanoclusters as the shell with ultra-low protein corona for enhanced photodynamic therapy

Abstract: Gold nanocluster (AuNCs) are well known in biosensing, bio-imaging and drug delivery areas and they can sensitize formation of singlet oxygen upon photoexcitation. However, to design the AuNCs with size...

Cited by 2 publications

References 40 publications

Review of Light-Activated Antimicrobial Nanoparticle–Polymer Composites for Biomedical Devices

Review of Light-Activated Antimicrobial Nanoparticle–Polymer Composites for Biomedical Devices

Tailoring gold nanocluster properties for biomedical applications: From sensing to bioimaging and theranostics

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