Tailoring gold nanocluster properties for biomedical applications: From sensing to bioimaging and theranostics

Mussa Farkhani, Samad; Dehghankelishadi, Pouya; Refaat, Ahmed; Veerasikku Gopal, Deepagan; Cifuentes-Rius, Anna; Voelcker, Nicolas H.

doi:10.1016/j.pmatsci.2023.101229

Cited by 10 publications

(3 citation statements)

References 467 publications

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“…89,90 The "kernel-origin" mechanism indicates that the HOMO−LUMO transition based on kernel-structure relaxation serves to the emission from AuNCs. 91,92 However, ligand and charge effects are the major factors that affects the luminescent property of AuNCs.…”

Section: Overview Of the Photoluminescence In Auncsmentioning

confidence: 99%

“…Electron-rich ligands can enhance the LMCT or LMMCT to improve the emission intensity . Additionally, newer insights reveal that “kernel-origin” mechanism is responsible for the emission of AuNCs and not the charge transfer mechanism or surface emission or intersystem crossing. , The “kernel-origin” mechanism indicates that the HOMO–LUMO transition based on kernel-structure relaxation serves to the emission from AuNCs. , However, ligand and charge effects are the major factors that affects the luminescent property of AuNCs.…”

Section: Origin and Strategy To Enhance Nir-ii Emission Of Gold Nanoc...mentioning

confidence: 99%

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Gold Nanoclusters as High Resolution NIR-II Theranostic Agents

Sharma,

Mohammad,

Le Guével

et al. 2024

Chemical & Biomedical Imaging

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In the realm of nanomaterials, atomically precise quasimolecular gold nanoclusters (AuNCs) play a prime role due to their unique, stable, and highly tunable optical properties. They are extensively structureengineered for modulation of surface electronic states toward long wavelength photoluminescence, particularly in the NIR-II (1000 to 1700 nm) window. Contrast agents with NIR-II emission can potentially transform optical imaging in terms of higher spatial resolution, deeper tissue penetration, and reduced tissue autofluorescence. These advantages allow real-time imaging in living organisms for observing disease progression and treatment response. In this short review, we discuss origin of NIR-II emission in rationally designed AuNCs and their application toward high resolution imaging of vasculatures and hard and soft tissue structures for identification of pathological conditions such as stroke and injury. Further, recent employment of these AuNCs in the rapidly growing field of tumor theranostics is also summarized. Final remarks are provided on the scope for improvement in their optical properties and persisting challenges for clinical translation.

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Section: Overview Of the Photoluminescence In Auncsmentioning

confidence: 99%

Section: Origin and Strategy To Enhance Nir-ii Emission Of Gold Nanoc...mentioning

confidence: 99%

Gold Nanoclusters as High Resolution NIR-II Theranostic Agents

Sharma,

Mohammad,

Le Guével

et al. 2024

Chemical & Biomedical Imaging

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“…6,10 In particular, gold nanoparticles, due to their excellent biocompatibility and tunable surface properties, have become a research hotspot. 11,12 Gold nanoparticles not only serve as drug delivery systems but also enable precise tumor localization and monitoring through methods like fluorescent labeling. 13…”

Section: Introductionmentioning

confidence: 99%

The biological response of pH-switch-based gold nanoparticle-composite polyamino acid embolic material

Yang,

Gong,

et al. 2024

Nanoscale

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Structure‐Dependent Photoluminescence and Chemiluminescence Emission Enhancement in Ag₂₅ Nanoclusters

Jing,

Kuang,

Fang

et al. 2024

Advanced Optical Materials

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Surface ligands crucially influence the structure and luminescence of metal nanoclusters (NCs). In this study, three [Ag25(SPhCl)16−xClx(DPPB)6]2+ (x = 0 for Ag25, x = 1 for Ag25‐Cl, and x = 4 for Ag25‐4Cl) featuring thiol and Cl ligand combinations are synthesized and investigated. Ag25‐4Cl, which has the smallest number of rigid thiol ligands, exhibits the strongest photoluminescence (PL) and chemiluminescence (CL), and its PL quantum yield is 73.43% higher than that of Ag25. Structural analysis indicates that Cl ligands, being smaller and less sterically hindering than thiols, compress the motif layer towards the core, reducing non‐radiative transitions and boosting radiative ones to enhance PL. All three NCs exhibit CL in the presence of singlet oxygen, demonstrating the ability of the NCs to react with radicals and scavenge them. CL and radical scavenging experiments show that Ag25‐4Cl exhibits the highest CL and the lowest radical reaction ability, indicating that CL intensity of an NC depends more on its intrinsic luminescence ability and less on its ability to react with radicals. The regulation of luminescence by ligands and the CL and radical‐scavenging behavior of NCs are expected to be extended to other NC systems and related applications.

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Tailoring gold nanocluster properties for biomedical applications: From sensing to bioimaging and theranostics

Cited by 10 publications

References 467 publications

Gold Nanoclusters as High Resolution NIR-II Theranostic Agents

Gold Nanoclusters as High Resolution NIR-II Theranostic Agents

The biological response of pH-switch-based gold nanoparticle-composite polyamino acid embolic material

Structure‐Dependent Photoluminescence and Chemiluminescence Emission Enhancement in Ag₂₅ Nanoclusters

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Tailoring gold nanocluster properties for biomedical applications: From sensing to bioimaging and theranostics

Cited by 10 publications

References 467 publications

Gold Nanoclusters as High Resolution NIR-II Theranostic Agents

Gold Nanoclusters as High Resolution NIR-II Theranostic Agents

The biological response of pH-switch-based gold nanoparticle-composite polyamino acid embolic material

Structure‐Dependent Photoluminescence and Chemiluminescence Emission Enhancement in Ag25 Nanoclusters

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Structure‐Dependent Photoluminescence and Chemiluminescence Emission Enhancement in Ag₂₅ Nanoclusters