Design of a continuous process for the production of highly substituted granular carboxymethyl starch

Tijsen, C.J; Voncken, R.M; Beenackers, A.A.C.M.

doi:10.1016/s0009-2509(00)00243-8

Cited by 27 publications

(15 citation statements)

References 19 publications

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“…In pharmaceutical industry, CMS is typically applied as tablets disintegrant; however, for that purpose mainly low substituted (DS ca. 0.3) polymer (partially crosslinked) under the name sodium starch glycolate is used 19, 64.…”

Section: Application Of Carboxymethyl Starchmentioning

confidence: 99%

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Medium and high substituted carboxymethyl starch: Synthesis, characterization and application

2012

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Carboxymethyl starch (CMS) could find application in many areas of industry. A review of synthesis methods of medium and high substituted CMS was presented. The influence of synthesis parameters on degree of substitution (DS) as well as reaction efficiency was described. The methodology of CMS physicochemical properties determination as well as the relation between CMS chemical characteristics (e.g. DS, amylose/amylopectin ratio) and its physicochemical properties was presented. Moreover, reported CMS applications were submitted.

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Section: Application Of Carboxymethyl Starchmentioning

confidence: 99%

“…Highly substituted CMS (DS 1.3) was applied as a thickener in reactive dye printing on textile 19. The dye reacts with primary hydroxyl groups of the cellulose fibres of the textile and forms a chemical bond.…”

Section: Application Of Carboxymethyl Starchmentioning

confidence: 99%

Medium and high substituted carboxymethyl starch: Synthesis, characterization and application

2012

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“…Many studies have discussed the influence of reaction medium, reagent concentrations, reaction temperature, and reaction time as main factors that determine the DS of carboxymethyl starch (6,(8)(9). Some of these studies determined the effects of reaction parameters on the carboxymethylation of starch by changing one variable while keeping the others constant.…”

Section: Introductionmentioning

confidence: 99%

Preparation and Application of Carboxymethyl Yam (Dioscorea esculenta) Starch

2009

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Abstract. Yam (Dioscorea esculenta) starch was modified by carboxymethylation. The effect of reaction parameters, amount of sodium hydroxide (NaOH), amount of sodium monochloroacetate (SMCA), and reaction time on the degree of substitution (DS) of carboxymethyl yam starch (CMS), was studied using the Box-Behnken experimental design. Physicochemical and potency to be a tablet disintegrant of CMS were evaluated. CMS with DS in the range of 0.08-0.19 were obtained. The results from regression analysis indicated that the most important factor in controlling DS was the amount of NaOH followed by SMCA content and reaction time. However, high concentration of NaOH and SMCA lowered the DS. The optimal conditions to achieve the highest DS (0.19) were found to be at molar ratios of NaOH and SMCA to anhydroglucose unit of 1.80 and 2.35, respectively, and with the reaction time of 4.8 h. The swelling power and viscosity of CMS increased with an increase in the degree of modification. CMS showed satisfying tablet disintegrant properties. The tablets containing 1.0-4.0 % CMS disintegrated faster than 5 min. Hence carboxymethyl yam starch can be used as an excellent tablet disintegrant in low concentration.

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“…Consequently, the granular CMS with high DS value and high rate of production can be obtained. On the other hand, the present dry method is different from the single alkaline catalysis reactions [3][4][5] of CMS, the compound catalysis of methanol and sodium hydroxide is used in the present process. Thus, the degree of substitution (DS) and reaction efficiency are obviously raised and the distribution of substituting groups is also improved by means of optimized reaction parameters.…”

Section: Pouring Testmentioning

confidence: 99%

“…A kind of new synthesis method for carboxymethyl starch was thus obtained on the principle of the methanol catalytic action. The method is different from other existing synthesis methods of CMS such as water solvent method [2], solvent method [3][4][5] and dry or * Corresponding author. Tel.…”

Section: Introductionmentioning

confidence: 99%