Design of 3D smart scaffolds using natural, synthetic and hybrid derived polymers for skin regenerative applications

Suamte, Laldinthari; Tirkey, Akriti; Babu, Punuri Jayasekhar

doi:10.1016/j.smaim.2022.09.005

Cited by 32 publications

(26 citation statements)

References 179 publications

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“…The hydrogel´s porosity should provide the necessary diffusion of oxygen and humidity without a negative effect or response with the biological surroundings, offering protection at the wound site [ 32 ]. The phases of wound healing are divided into inflammation, deterioration, and maturation, although some authors describe it with some intermediate phases, mainly those that overlap each other [ 7 , 14 ]. Inflammation implies coagulation, vasoconstriction, and fibrin formation.…”

Section: Resultsmentioning

confidence: 99%

“…Proliferation implies re-epithelialization, neovascularization of blood vessels (angiogenesis), and granulation tissue. Finally, maturation implies the reorganization of the extracellular matrix, degradation, and resynthetization [ 7 ]. According to the results in Table 3 , the evaluation of the histological parameters shows that the presence of the hydrogel in the wound site does not alter the order of the mentioned phases of the healing process.…”

Section: Resultsmentioning

confidence: 99%

“…Synthetic and natural polymers have been widely studied for the development of hydrogels or xerogels for wound healing. Synthetic polymers such as poly(ethylene glycol), poly(vinyl alcohol) poly(glycolic acid), poly(lactic-co-glycolic acid), and poly(caprolactone) [ 7 , 8 , 9 ] and natural polysaccharide- and protein-based polymers such as cellulose, chitosan, collagen, alginate, hyaluronic acid, or pectin have been approved by US Food and Drug Administration (FDA) for medical applications [ 10 , 11 , 12 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

“…Reports on cellulose, chitosan, collagen, and pectin show the acceleration in the formation of new cellular mass and extracellular matrix [ 7 , 14 , 15 ]. Some of the essential needs for wound healing are non-alteration of the tissue repair phases due to gel presence and control of wound exudates due to porosity [ 7 , 14 , 16 ].…”

Section: Introductionmentioning

confidence: 99%

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Characterization and In Vivo Assay of Allantoin-Enriched Pectin Hydrogel for the Treatment of Skin Wounds

Saucedo-Acuña

Meza-Valle

Cuevas-González

et al. 2023

IJMS

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This work describes a liquid allantoin-enriched pectin hydrogel with hydrophilic behavior that is supported by the presence of functional groups related to healing efficacy. A topical study shows the effect of the hydrogel application on surgically induced skin wound healing in a rat model. Contact angle measurements confirm hydrophilic behavior (11.37°), while Fourier-transform infrared spectroscopy indicates the presence of functional groups related to the healing effectiveness (carboxylic acid and amine groups). Allantoin is distributed on the surface and inside the amorphous pectin hydrogel surrounded by a heterogeneous distribution of pores. This promotes wound drying with better interaction between the hydrogel and cells involved in the wound healing process. An experimental study with female Wistar rats indicates that the hydrogel improves wound contraction, reducing around 71.43% of the total healing time and reaching total wound closure in 15 days.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Characterization and In Vivo Assay of Allantoin-Enriched Pectin Hydrogel for the Treatment of Skin Wounds

Saucedo-Acuña

Meza-Valle

Cuevas-González

et al. 2023

IJMS

View full text Add to dashboard Cite

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“…Natural polymers are acquired from natural materials and provide an assurance of natural restructure, biomimetic nature, and bioactivity [ 75 ]. Natural polymer derivatives refer to more complex products which derived from the substitution of atoms or atomic groups of natural polymers.…”

Section: Materials For 3d Bioprintingmentioning

confidence: 99%

Convergence of 3D Bioprinting and Nanotechnology in Tissue Engineering Scaffolds

et al. 2023

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Three-dimensional (3D) bioprinting has emerged as a promising scaffold fabrication strategy for tissue engineering with excellent control over scaffold geometry and microstructure. Nanobiomaterials as bioinks play a key role in manipulating the cellular microenvironment to alter its growth and development. This review first introduces the commonly used nanomaterials in tissue engineering scaffolds, including natural polymers, synthetic polymers, and polymer derivatives, and reveals the improvement of nanomaterials on scaffold performance. Second, the 3D bioprinting technologies of inkjet-based bioprinting, extrusion-based bioprinting, laser-assisted bioprinting, and stereolithography bioprinting are comprehensively itemized, and the advantages and underlying mechanisms are revealed. Then the convergence of 3D bioprinting and nanotechnology applications in tissue engineering scaffolds, such as bone, nerve, blood vessel, tendon, and internal organs, are discussed. Finally, the challenges and perspectives of convergence of 3D bioprinting and nanotechnology are proposed. This review will provide scientific guidance to develop 3D bioprinting tissue engineering scaffolds by nanotechnology.

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Integration of Tumor Elimination And Tissue Regeneration via Selective Manipulation of Physiological Microenvironments Based on Intelligent Nanocomposite Hydrogel for Postoperative Treatment of Malignant Melanoma

Chen

Yang

Weng

et al. 2023

Adv Funct Materials

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Tumor residue and tissue damage normally occurred after surgical treatment of malignant melanoma, and the effective postoperative therapy is still a challenge because the treatment requests simultaneous but opposite manipulation of tumor cells and healthy cells. Herein, MBGP‐Gel, a thermosensitive and biodegradable hydrogel incorporating S‐nitrosoglutathione (GSNO) loaded and N‐aminoethyl‐N’‐benzoyl thiourea (BTU) modified MSNs (MBGP NPs), was designed to utilize the significant difference of copper content between tumor cells and healthy cells to regulate various physiological microenvironments for integrative therapy of tumor elimination, metastasis inhibition and tissue regeneration. The MBGP‐Gel underwent sol‐gel transformation at body temperature after injection, and continuously released MBGP nanoparticles. In tumor cells, these nanoparticles would chelate the excess copper to inhibit the tumor migration. Meanwhile, copper was reduced to cuprous, which further catalyzed the abundant H2O2 and GSNO to produce oxygen species (ROS) and nitric oxide (NO), respectively. The ROS and the reaction product of ROS and NO (ONOO) would significantly damage the tumor tissue. In contrast, MBGP nanoparticles entered healthy cells only generate appropriate amount of NO to accelerate tissue healing. Both in vitro and in vivo results showed that the nanocomposite hydrogel could inhibit the growth and metastasis of malignant melanoma and promote the skin regeneration, which offered an promising strategy for postoperative treatment of various tumors.

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Design of 3D smart scaffolds using natural, synthetic and hybrid derived polymers for skin regenerative applications

Cited by 32 publications

References 179 publications

Characterization and In Vivo Assay of Allantoin-Enriched Pectin Hydrogel for the Treatment of Skin Wounds

Characterization and In Vivo Assay of Allantoin-Enriched Pectin Hydrogel for the Treatment of Skin Wounds

Convergence of 3D Bioprinting and Nanotechnology in Tissue Engineering Scaffolds

Integration of Tumor Elimination And Tissue Regeneration via Selective Manipulation of Physiological Microenvironments Based on Intelligent Nanocomposite Hydrogel for Postoperative Treatment of Malignant Melanoma

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