Design, formulation, and evaluation of in situ gelling ophthalmic drug delivery system comprising anionic and nonionic polymers

Dasankoppa, Fatima Sanjeri; Solankiy, Pooja; Sholapur, Hasanpasha; Jamakandi, Vilas G; Sajjanar, Vinuta M; Walveka, Pooja M

doi:10.4103/kleuhsj.kleuhsj_131_17

Cited by 12 publications

(9 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The concentrations of polymers are crucial on the effects of residence time, viscosity, as well as the release of the drug within the gelling system [ 9 ]. HPMC and SA have been decided as the bioadhesive polymers to be used in the development of the formulation.…”

Section: Discussionmentioning

confidence: 99%

“…In this regard, using an in situ gel with a prolonged contact time and a sustained drug release effect could improve the therapeutic efficacy as the inflammation is mainly found at the epidermis and upper dermis skin layer [ 8 ]. In situ gels are viscous liquids which have a unique characteristic of undergoing sol-to-gel transitions by the influence of various stimuli, namely pH, temperature, and electrolytes [ 9 ]. In this study, the focus of sol-gel transition was made on the temperature-dependent factors, where the conversion of sol-to-gel conversion was projected to the stimuli of skin temperature.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Development of In-Situ Spray for Local Delivery of Antibacterial Drug for Hidradenitis Suppurativa: Investigation of Alternative Formulation

et al. 2021

View full text Add to dashboard Cite

Hidradenitis suppurativa (HS) has been considered an orphan disease with limited treatments available. The available topical treatment for this condition is clindamycin lotion; however, short retention and frequent application are the main setbacks. Thus, the present study aimed to attain an optimized antibacterial in situ spray formulation for the hidradenitis suppurativa skin condition, which gels once in contact with the skin surface at around 37 °C and possesses bioadhesion as well as sustained-release properties of the incorporated drug. Different concentrations of thermo-reversible gelling polymer, Pluronic F-127, were investigated along with the selected bioadhesive polymers, HPMC and SA. The optimized formulation F3 consisting of 18% Pluronic F-127 with 0.2% HPMC and 0.2% SA was characterized based on various physicochemical properties. The gelation temperature of F3 was found to be 29.0 ± 0.50 °C with a gelation time of 1.35 ± 0.40 min and a pH of 5.8. F3 had the viscosity of 178.50 ± 5.50 cP at 25 °C and 7800 ± 200 cP at 37 °C as the gel set. The optimized formulation was found to be bioadhesive and cytocompatible. Cumulative drug release was 65.05% within the time-frame of 8 h; the release pattern of the drug followed zero-order kinetics with the Higuchi release mechanism. The average zone of inhibition was found to be 43.44 ± 1.34 mm. The properties of F3 formulation reflect to improve residence time at the site of application and can enhance sustained drug release. Therefore, it could be concluded that optimized formulation has better retention and enhanced antimicrobial activity for superior efficacy against HS.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Development of In-Situ Spray for Local Delivery of Antibacterial Drug for Hidradenitis Suppurativa: Investigation of Alternative Formulation

et al. 2021

View full text Add to dashboard Cite

show abstract

“…The spindle angular velocity was increased to 0.3, 0.5, 0.6, 1, 1.5, 2, 2.5, 3.4, 5, 6, 10, and the viscosity of the formulation was recorded. 26…”

Section: Viscosity Measurementmentioning

confidence: 99%

Relationship of HbA1c Values to Retinopathy, Nephropathy, and Cardiovascular

Al-Hakeem¹,

Saleh²

2020

ijddt

View full text Add to dashboard Cite

A total of 50 patients aged 35-75 years From Al-Sader educational Hospital in Al-Najaf city was studied to determine the glycated hemoglobin risk factors with value creatinine and urea in serum and diabetic nephropathy. Diabetic patient were (35-45 years old) with HbA1c 7.9 % (60mmol/mol). Patient were (45–55 years old), glycated hemoglobin (HbA1c) andgt; 8.5 %. Patients between (55–65 years were glycated hemoglobin (HbA1c) andgt;10.5 %. HbA1c levels, lipid profile, level of Creatinine and urea in serum, family history, BMI, blood pressure, disease severity, and complications were determined. Most patients developed some grade of retinopathy (examined by an ophthalmologist) except those with HbA1c 6.7% (50mmol/mol). Diabetic patients aged (55–65 years old) with HbA1c 7.6% (60mmol/mol). Patients aged 56–75 years old of glycated hemoglobin (HbA1c) andgt;7% with poor glycaemia control ≥ 126mg/dL were assessed to classify diabetic retinopathy. HbA1c and GA are associated with nephropathy separately. Retinopathy and nephropathy may respond to different aspects of hyperglycemia. The GA found as a powerful indicator of microvascular complications same as HbA1c where long-term glycaemia is the risk factor.

show abstract

“…To cope with these drawbacks, in situ gel systems have emerged as one of the best novel drug delivery systems. It can enhance the bioavailability of ocular drugs by sustaining and controlling the release of drugs in the pre-corneal region [10,11]. In situ drug delivery systems consist of polymers that develop sol-to-gel phase transition due to changes such as temperature, pH or electrolyte composition of the eye environment [12,13].…”

Section: Introductionmentioning

confidence: 99%

In Vitro Drug Release Study of Chloramphenicol in Situ Gel With Bases Mixture of Poloxamer 407 and HPMC by Optimization With Factorial Design

et al. 2021

View full text Add to dashboard Cite

Objective: The objective of this study was to find the best base mixture composition (poloxamer 407 and HPMC) of chloramphenicol in situ gel formula based on in vitro property (Cumulative amount of drug release). Methods: The in vitro diffusion of chloramphenicol in situ gel study was carried out using franz diffusion cells to know the effect of the Critical Process Parameters (CPPs) as independent variables (poloxamer 407 and hydroxypropyl methylcellulose (HPMC)) on the Critical Quality Attribute (CQA) as dependent variable (cumulative amount of drug release) with 22 factorial design. Results: 22 factorial design of chloramphenicol in situ gel yielded 4 variations of poloxamer 407 and HPMC bases component in %w/v as follows, F1 (5:0.45), F2 (10:0.45) F3 (5:1) and F4 (10:1). The amount of drug release results from in vitro dissolution assay were 30.60% (F1), 45.64% (F2), 58.30% (F3), and 22.50%) (F4). Conclusion: Formula 3 (F3) was considered as the best formula component in terms of in vitro assay of chloramphenicol in situ gel with a desirability value of 0.58.

show abstract

Design, formulation, and evaluation of in situ gelling ophthalmic drug delivery system comprising anionic and nonionic polymers

Cited by 12 publications

References 2 publications

Development of In-Situ Spray for Local Delivery of Antibacterial Drug for Hidradenitis Suppurativa: Investigation of Alternative Formulation

Development of In-Situ Spray for Local Delivery of Antibacterial Drug for Hidradenitis Suppurativa: Investigation of Alternative Formulation

Relationship of HbA1c Values to Retinopathy, Nephropathy, and Cardiovascular

In Vitro Drug Release Study of Chloramphenicol in Situ Gel With Bases Mixture of Poloxamer 407 and HPMC by Optimization With Factorial Design

Contact Info

Product

Resources

About