Design, Formulation and Evaluation of Topical Nimesulide Emulgel

Abstract

Emulgel is one of the recent technologies in Novel DDS used for dual control release of emulsion and gel for topical use. In the present Investigation, topical gel and emulgels of Nimesulide were formulated using 2 3 Factorial Design and Carboplol 934 as a polymer.The oral use of Nimesulide is associated with side effects like gastrointestinal disturbances, epigastric pain, nausea, heartburn, vomiting and diarrhea. Topical application of the drug prevents these side effects and offers potential advantage of delivering the drug at the site of action. The rational of the present study was to increase the penetration of drug into the skin.The Formulations were subjected to various physicochemical studies such as spreading coefficnt, Vioscosity and in vitro release studies. In vitro release of the tests formulations was performed to determine drug release from Gel and emulgel. From the in vitro studies, formulation F4 showed maximum release of 59.58% in 240 min and 45.02% from the Gel. In vitro release studies of the prepared formulation were performed using dialysis membrane and results indicated that Emulgel showed better release than Gel system.

Development and characteristics of topical gel containing nimesulide: A review

“…It is more tolerated than other NSAIDs the terminal half-life of nimesulide is about 4 hrs. it is Cox 2 inhibitor used for variety of inflammatory pain and fever state gel are cross linked polymer network that expand in a liquid medium it's properties mainly depend on the interaction of solid polymer and liquid component the gel does not spread evenly gel formulation provide an appropriate these delivery systems for the drugs are less greasy and can be easily removed from the skin [14,15].…”

Exploring the gelling properties of Plantago ovata-based Arabinoxylan: Fabrication and optimization of a topical emulgel using response surface methodology

“…As illustrtaed in Table 1, fifteen formulations (F1 to F15) were designed based upon different concentrations of AX, span 80 and tween 20, being considered the independent variables and their concentrations were chosen by a review of the literature [18][19][20]. The selection of the ratio factors for AX, span 80 and tween 20 were decided using, Design Expert 10, software, Response surface methodology (Stat-Ease, Inc., Minneapolis, Minnesota, USA) to get optimize emulgel formulations.…”