This chapter provides a brief overview of the types of wearable antennas with high body-antenna isolation. The main parameters and characteristics of wearable antennas and their design requirements are discussed. Next, procedures (passive and active) to test the performance of wearable antennas are presented. The electromagnetic properties of the commercially available textiles used as antenna substrates are investigated and summarized here, followed by a more detailed examination of their effects on the performance of wearable antennas with high body-antenna isolation. A trade-off between substrate electromagnetic properties and resonant frequency, bandwidth, radiation efficiency, and maximum gain is presented. Finally, a case study is presented with detailed analyses and investigations of the low-profile all-textile wearable antennas with high body-antenna isolation and low SAR. Their interaction with a semisolid homogeneous human body phantom is discussed. The simulations and experimental results from different (in free-space and on-body) scenarios are presented.