Design, evaluation, and optimization of 3D printed truss scaffolds for bone tissue engineering

Shirzad, Masoud; Zolfagharian, Ali; Matbouei, Alireza; Bodaghi, Mahdi

doi:10.1016/j.jmbbm.2021.104594

Cited by 45 publications

(25 citation statements)

References 36 publications

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“…This gives an opportunity to evaluate stress distributions over time during physiological wrist motion-an achievement not previously reported in the literature. Furthermore, published FEA studies of 3D-printed scaffolds [32,59] cover only bone plug of current construct (see Fig 2). Due to novelty of current design and application, no one so far has evaluated the ligament-scaffold performance which plays an important role bearing the major loads from wrist motion.…”

Section: Plos Onementioning

confidence: 99%

“…Numerous conventional methods and advanced fabrication techniques have been introduced for scaffold manufacturing to replace tissue or organs employing solvent-casting particulate leaching [28] in combination with melt molding [29], gas foaming [30], and phase-separation [31]. More recently, 3D printing (digital light processing [32], fused deposition modeling [33] and robocasting [34]) have offered better control over the architecture and physical properties of the scaffold, thereby enabling the manufacturing of patient-specific constructs [35,36]. Recently, a multiphasic bone-ligament-bone (BLB) scaffold [27] has been proposed to reconstruct the dorsal SLIL, and which can be 3D-printed using medical grade polycaprolactone (PCL).…”

Section: Introductionmentioning

confidence: 99%

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Finite element analysis of the performance of additively manufactured scaffolds for scapholunate ligament reconstruction

et al. 2021

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Rupture of the scapholunate interosseous ligament can cause the dissociation of scaphoid and lunate bones, resulting in impaired wrist function. Current treatments (e.g., tendon-based surgical reconstruction, screw-based fixation, fusion, or carpectomy) may restore wrist stability, but do not address regeneration of the ruptured ligament, and may result in wrist functional limitations and osteoarthritis. Recently a novel multiphasic bone-ligament-bone scaffold was proposed, which aims to reconstruct the ruptured ligament, and which can be 3D-printed using medical-grade polycaprolactone. This scaffold is composed of a central ligament-scaffold section and features a bone attachment terminal at either end. Since the ligament-scaffold is the primary load bearing structure during physiological wrist motion, its geometry, mechanical properties, and the surgical placement of the scaffold are critical for performance optimisation. This study presents a patient-specific computational biomechanical evaluation of the effect of scaffold length, and positioning of the bone attachment sites. Through segmentation and image processing of medical image data for natural wrist motion, detailed 3D geometries as well as patient-specific physiological wrist motion could be derived. This data formed the input for detailed finite element analysis, enabling computational of scaffold stress and strain distributions, which are key predictors of scaffold structural integrity. The computational analysis demonstrated that longer scaffolds present reduced peak scaffold stresses and a more homogeneous stress state compared to shorter scaffolds. Furthermore, it was found that scaffolds attached at proximal sites experience lower stresses than those attached at distal sites. However, scaffold length, rather than bone terminal location, most strongly influences peak stress. For each scaffold terminal placement configuration, a basic metric was computed indicative of bone fracture risk. This metric was the minimum distance from the bone surface to the internal scaffold bone terminal. Analysis of this minimum bone thickness data confirmed further optimisation of terminal locations is warranted.

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Section: Plos Onementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Finite element analysis of the performance of additively manufactured scaffolds for scapholunate ligament reconstruction

et al. 2021

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“…The use of additive manufacturing and three-dimensional (3D) printers is very popular these days[ 1 - 3 ], and they have various applications in various industries, including aerospace[ 4 ], automotive[ 5 ], soft robotics[ 6 ], construction[ 7 ], food printing[ 8 ], and tissue engineering[ 9 , 10 ]. One of these is the custom manufacturing of products.…”

Section: Introductionmentioning

confidence: 99%

Custom Shoe Sole Design and Modeling Toward 3D Printing

Zolfagharian¹,

Lakhi²,

Ranjbar³

et al. 2024

IJB

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This study introduces a design procedure for improving an individual’s footwear comfort with body weight index and activity requirements by customized three-dimensional (3D)-printed shoe midsole lattice structure. This method guides the selection of customized 3D-printed fabrications incorporating both physical and geometrical properties that meet user demands. The analysis of the lattice effects on minimizing the stress on plantar pressure was performed by initially creating various shoe midsole lattice structures designed. An appropriate common 3D printable material was selected along with validating its viscoelastic properties using finite element analysis. The lattice structure designs were analyzed under various loading conditions to investigate the suitability of the method in fabricating a customized 3D-printed shoe midsole based on the individual’s specifications using a single material with minimum cost, time, and material use.

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“…FFF allows printing different thermoplastic polymers with microscale resolution. Indeed, printing of conventional polymers, such as poly(acrylonitrile- co -butadiene- co -styrene) (ABS) [ 21 ], poly(lactic acid) (PLA) [ 22 ], polycaprolactone, [ 23 , 24 ] or poly(methyl-methacrylate), [ 25 ], has been thoroughly investigated and, in fact, this technology is commercially available and commonly used. In their pioneering work [ 23 ], Hutmacher et al .…”

Section: Introductionmentioning

confidence: 99%

Characterization of biocompatible scaffolds manufactured by fused filament fabrication of poly(3-hydroxybutyrate- co -3-hydroxyhexanoate)

et al. 2022

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We characterize poly(3-hydroxybutyrate- co -3-hydroxyhexanoate) (PHBH) scaffolds for tissue repair and regeneration, manufactured by three-dimensional fused filament fabrication (FFF). PHBH belongs to the class of polyhydroxyalkanoates with interesting biodegradable and biocompatible capabilities, especially attractive for tissue engineering. Equally, FFF stands as a promising manufacturing technology for the production of custom-designed scaffolds. We address thermal, rheological and cytotoxicity properties of PHBH, placing special emphasis on the mechanical response of the printed material in a wide deformation range. Indeed, effective mechanical properties are assessed in both the linear and nonlinear regime. To warrant uniqueness of the material parameters, these are measured directly through digital image correlation, both in tension and compression, while experimental data fitting of finite-element analyses is only adopted for the determination of the second invariant coefficient in the nonlinear regime. Mechanical data are clearly porosity dependent, and they are given for both the cubic and the honeycomb infill pattern. Local strain spikes due to the presence of defects are observed and measured: those falling in the range 70–100% lead to macro-crack development and, ultimately, to failure. Results suggest the significant potential attached to FFF printing of PHBH for customizable medical devices which are biocompatible and mechanically resilient.

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Design, evaluation, and optimization of 3D printed truss scaffolds for bone tissue engineering

Cited by 45 publications

References 36 publications

Finite element analysis of the performance of additively manufactured scaffolds for scapholunate ligament reconstruction

Finite element analysis of the performance of additively manufactured scaffolds for scapholunate ligament reconstruction

Custom Shoe Sole Design and Modeling Toward 3D Printing

Characterization of biocompatible scaffolds manufactured by fused filament fabrication of poly(3-hydroxybutyrate- co -3-hydroxyhexanoate)

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