Design and verification tools for continuous fluid flow-based microfluidic devices

McDaniel, Jeffrey; Baez, A.; Crites, Brian; Tammewar, A.; Brisk, Philip

doi:10.1109/aspdac.2013.6509599

Cited by 17 publications

(20 citation statements)

References 21 publications

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“…The netlist can be generated from an MHDL specification [6] or from a synthesis Figure 2. The main stages of our software toolflow.…”

Section: System Overviewmentioning

confidence: 99%

“…If desired, the netlist can be converted to the microfluidic hardware description language (MHDL), which is human readable representation. MHDL is extensible, allowing the user to describe both the technology and architectural entities within their own respective library files [6].…”

Section: Introductionmentioning

confidence: 99%

“…Extensibility allows device engineers to continuously extend our toolflow whenever they develop new technologies and/or entities. The technology library file describes fabrication constraints, while the entity library files specify the capabilities and constraints of each component [6]. During component expansion, in which vertices (points) in the netlist are replaced with 2-D microfluidic components, the placer obtains the dimensions of each component from its entity library file.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Flow-Layer Physical Design for Microchips Based on Monolithic Membrane Valves

et al. 2015

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“…The netlist can be generated from an MHDL specification [6] or from a synthesis Figure 2. The main stages of our software toolflow.…”

Section: System Overviewmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Flow-Layer Physical Design for Microchips Based on Monolithic Membrane Valves

et al. 2015

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“…One recent academic proposal is the Microfluidic Hardware Design Language (MHDL) [41], which borrows much of its syntax from VHDL. An MHDL specification of an mLSI chip includes a list of components (e.g.…”

Section: Automated Mlsi Chip Design and Layoutmentioning

confidence: 99%

Recent developments in microfluidic large scale integration

Araci

Brisk

2014

Current Opinion in Biotechnology

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In 2002, Thorsen et al. integrated thousands of micromechanical valves on a single microfluidic chip and demonstrated that the control of the fluidic networks can be simplified through multiplexors [1]. This enabled realization of highly parallel and automated fluidic processes with substantial sample economy advantage. Moreover, the fabrication of these devices by multilayer soft lithography was easy and reliable hence contributed to the power of the technology; microfluidic large scale integration (mLSI). Since then, mLSI has found use in wide variety of applications in biology and chemistry. In the meantime, efforts to improve the technology have been ongoing. These efforts mostly focus on; novel materials, components, micromechanical valve actuation methods, and chip architectures for mLSI. In this review, these technological advances are discussed and, recent examples of the mLSI applications are summarized. Recent advancements in microfluidic technologies have created new opportunities in the fields of biology and chemistry through miniaturization and automation of common processes, including mixing, metering, trapping, reaction, filtering, and separation, among others. Microfluidic large scale integration (mLSI) enables the fabrication of microfluidic chips containing hundreds or more of these functions using well-established lithography techniques, similar in principle to electronic LSI in the semiconductor industry [1]. Small feature dimensions, abundant spatial parallelism, and control over fluid flow provide mLSI technology with advantages such as high throughput, precise metering, automation and low reagent consumption. The implications of mLSI technology can especially be seen in recent advances in single cell, genomic, and protein analysis.

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“…Figure 1 illustrates the automatic synthesis flow. It makes use of a lower-level compiler and simulation environment [5], as well as a collection of algorithms that synthesize and physically layout the mLSI chip, starting from a sequencing graph specification [2,8]. The assay is specified using an mLSI-compatible subset of the BioCoder language [3] (Section II.A).…”

Section: A Microfluidic Design Automation (Mda)mentioning

confidence: 99%

Automatic synthesis of microfluidic large scale integration chips from a domain-specific language

McDaniel

Curtis

Brisk

2013

2013 IEEE Biomedical Circuits and Systems Conference (BioCAS)

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Abstract-BioCoder is a domain-specific language by which chemists and biologists can express experimental protocols in a manner that is unambiguous and clearly repeatable. This paper presents a software toolchain that converts a protocol specified in a restricted subset of BioCoder to a technology-specific description of the protocol, targeting flow-based microfluidic large-scale integration (mLSI) chips. The technology-specific description can then be used to either: (1) execute the protocol on a capable chip; or (2) to derive the architecture of a new mLSI chip that can execute the protocol.

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Design and verification tools for continuous fluid flow-based microfluidic devices

Cited by 17 publications

References 21 publications

Flow-Layer Physical Design for Microchips Based on Monolithic Membrane Valves

Flow-Layer Physical Design for Microchips Based on Monolithic Membrane Valves

Recent developments in microfluidic large scale integration

Automatic synthesis of microfluidic large scale integration chips from a domain-specific language

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