Design and Validation of Synchronous QCT Calibration Phantom: Practical Methodology

Malekzadeh, Malakeh; Abbasi-Rad, Shahrokh; Shahgholi, Mohamad; Naghdi, Parisa; Hoseini, Marzieh Sadat; Yazdi, Niloofar Ayoobi; Shiran, Mohammad Reza; Rad, Hamidreza Saligheh

doi:10.1016/j.jmir.2018.10.002

Cited by 13 publications

(6 citation statements)

References 15 publications

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“…To produce nanofibers, one of the high-voltage power supply electrodes are connected to a polymer, the other solution to the ground or to a conductive collector. [17][18][19][20][21][22][23][24][25] By passing the solution from the inside of the capillary tube, the fluid is drained from the tip of the capillary tube to the collector due to the electric field generated by the high voltage supply between the tip of the copper tube and the collector connected to the earth. Due to the fluid motion, the solvent is evaporated and filaments with a diameter below a micron are produced on the collector.…”

Section: A Compressive Review Of Wound Dressing Methods and Techniques The Electrospinning Methodsmentioning

confidence: 99%

“…To discuss the infectious wounds, there is a microbial agent in the wound. 23 Pain is the classic presenting complaint, and infected wounds typically contain thick, pustular, and serosanguinous secretions and, if not addressed promptly, the infection spreads to the surrounding tissue and can cause sepsis. 24 It is commonly stated that the only two pathologies that can be visualized are anthrax and jaundice that can be easily recognized by their appearance.…”

Section: A Review On Polymeric Wound Dress For the Treatment Of Burns And Diabetic Woundsmentioning

confidence: 99%

“…The submerged lube is sucked out of the drying chamber by a vacuum pump or a steam evaporator. [22][23][24][25][26][27][28][29] The heat required for sublimation is provided by conduction or radiation. The frozen water is sublimated at or below 0°C under a pressure of 627 Pa (0.6 mbar) or less.…”

Section: Figurementioning

confidence: 99%

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A Review on Polymeric Wound Dress for the Treatment of Burns and Diabetic Wounds

Farazin

Torkpour

Dehghani

et al. 2021

Int J Basic Sci Med

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Today, various commercial dressings have been developed and introduced to the market. The diversity makes it difficult for the nurse to choose the right type. Although the most important reason to use a wound dress is to protect the wound from infection and prevent infection, but in fact, the main purpose of using these materials is to speed up the wound healing process. Traumatic injuries result in an epithelial wound that disrupts the continuity of the skin surface. These differences reveal as abrasions, punctures, and injuries. Wounds are divided into two types; the skin is either cut or ruptured, including deep wounds and bruises, or surface wounds. Expedited wound healing has been considered since the archaic era of human civilization, with the earliest reported case from the Ancient Egyptians. Wound lesions in mummified humans were observed to be cover with animal skin, with signs of (primary/secondary) wound healing present. A "new wound dressing" is an advanced wound dress used in wound management as biocompatible and biodegradable biomaterials that heal wounds and burns. In the past, it was believed that dry wounds had expedited healing and wet wounds have been found to promote using re-epithelization and result in reduced scar formation. Wounds can be treated using various types of natural polymers and materials. Also, techniques like electrospinning and freeze-drying techniques can be used for the fabrication of standard wound dress. These wounds are associated with bandages, inflammation, bleeding, pain, and pus. In this work, we consider various types of wounds and techniques to treat the wound. Susceptibility to these areas, due to special symptoms for each of them. Products like hydrogels, hydrocolloids, films, sponges, and nano-fiber polymeric materials are used to promote healing. In this review, we examine the ideal products for the treatment of wounds in diabetic patients.

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Section: A Compressive Review Of Wound Dressing Methods and Techniques The Electrospinning Methodsmentioning

confidence: 99%

Section: A Review On Polymeric Wound Dress For the Treatment Of Burns And Diabetic Woundsmentioning

confidence: 99%

See 1 more Smart Citation

A Review on Polymeric Wound Dress for the Treatment of Burns and Diabetic Wounds

Farazin

Torkpour

Dehghani

et al. 2021

Int J Basic Sci Med

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“…Studies have shown that subjects with normal aBMD values suffered from osteoporotic fractures and vice versa (8,9). Quantitative computed tomography (QCT) can be used in place of DXA to measure volumetric BMD from the attenuation values using a calibration phantom (10)(11)(12)(13).…”

Section: Introductionmentioning

confidence: 99%

Predicting Vertebral Bone Strength Using Finite Element Analysis for Opportunistic Osteoporosis Screening in Routine Multidetector Computed Tomography Scans—A Feasibility Study

et al. 2021

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PurposeTo investigate the feasibility of using routine clinical multidetector computed tomography (MDCT) scans for conducting finite element (FE) analysis to predict vertebral bone strength for opportunistic osteoporosis screening.MethodsRoutine abdominal MDCT with and without intravenous contrast medium (IVCM) of seven subjects (five male; two female; mean age: 71.86 ± 7.40 years) without any bone disease were used. FE analysis was performed on individual vertebrae (T11, T12, L1, and L2) including the posterior elements to investigate the effect of IVCM and slice thickness (1 and 3 mm) on vertebral bone strength. Another subset of data from subjects with vs. without osteoporotic vertebral fractures (n = 9 age and gender-matched pairs) was analyzed for investigating the ability of FE-analysis to differentiate the two cohorts. Bland-Altman plots, box plots, and coefficient of correlation (R2) were calculated to determine the variations in FE-predicted failure loads for different conditions.ResultsThe FE-predicted failure loads obtained from routine MDCT scans were strongly correlated with those from without IVCM (R2 = 0.91 for 1mm; R2 = 0.92 for 3mm slice thickness, respectively) and different slice thicknesses (R2 = 0.93 for 1mm vs. 3mm with IVCM). Furthermore, a good correlation was observed for 3mm slice thickness with IVCM vs. 1mm without IVCM (R2 = 0.87). Significant difference between FE-predicted failure loads of healthy and fractured patients was observed (4,705 ± 1,238 vs. 4,010 ± 1,297 N; p=0.026).ConclusionRoutine clinical MDCT scans could be reliably used for assessment of fracture risk based on FE analysis and may be beneficial for patients who are at increased risk for osteoporotic fractures.

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“…Also, the complex anatomical structure of bone tissue emphasizes the importance of considering the critical interaction between different structural elements of the bone while assessing bone fracture risk (10). Quantitative computed tomography (QCT) imaging has been used in place of DXA to measure volumetric BMD from attenuation values, calibrated using a phantom, in assessing bone quality and condition (11)(12)(13)(14).…”

Section: Introductionmentioning

confidence: 99%

Finite Element Analysis-Based Vertebral Bone Strength Prediction Using MDCT Data: How Low Can We Go?

et al. 2020

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Objective: To study the impact of dose reduction in MDCT images through tube current reduction or sparse sampling on the vertebral bone strength prediction using finite element (FE) analysis for fracture risk assessment. Methods: Routine MDCT data covering lumbar vertebrae of 12 subjects (six male; six female; 74.70 ± 9.13 years old) were included in this study. Sparsely sampled and virtually reduced tube current-based MDCT images were computed using statistical iterative reconstruction (SIR) with reduced dose levels at 50, 25, and 10% of the tube current and original projections, respectively. Subject-specific static non-linear FE analyses were performed on vertebra models (L1, L2, and L3) 3-D-reconstructed from those dose-reduced MDCT images to predict bone strength. Coefficient of correlation (R 2), Bland-Altman plots, and root mean square coefficient of variation (RMSCV) were calculated to find the variation in the FE-predicted strength at different dose levels, using high-intensity dose-based strength as the reference. Results: FE-predicted failure loads were not significantly affected by up to 90% dose reduction through sparse sampling (R 2 = 0.93, RMSCV = 8.6% for 50%; R 2 = 0.89, RMSCV = 11.90% for 75%; R 2 = 0.86, RMSCV = 11.30% for 90%) and up to 50% dose reduction through tube current reduction method (R 2 = 0.96, RMSCV = 12.06%). However, further reduction in dose with the tube current reduction method affected the ability to predict the failure load accurately (R 2 = 0.88, RMSCV = 22.04% for 75%; R 2 = 0.43, RMSCV = 54.18% for 90%). Conclusion: Results from this study suggest that a 50% radiation dose reduction through reduced tube current and a 90% radiation dose reduction through sparse sampling can be used to predict vertebral bone strength. Our findings suggest that the sparse sampling-based method performs better than the tube current-reduction method in generating images required for FE-based bone strength prediction models.

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Design and Validation of Synchronous QCT Calibration Phantom: Practical Methodology

Cited by 13 publications

References 15 publications

A Review on Polymeric Wound Dress for the Treatment of Burns and Diabetic Wounds

A Review on Polymeric Wound Dress for the Treatment of Burns and Diabetic Wounds

Predicting Vertebral Bone Strength Using Finite Element Analysis for Opportunistic Osteoporosis Screening in Routine Multidetector Computed Tomography Scans—A Feasibility Study

Finite Element Analysis-Based Vertebral Bone Strength Prediction Using MDCT Data: How Low Can We Go?

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