Design and Synthesis of Sebacic Acid from Castor Oil by New Alternate Route

Bhukya, Gandhi; Kaki, Shiva Shanker

doi:10.1002/ejlt.202100244

Cited by 10 publications

(6 citation statements)

References 26 publications

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“…Since saponification/methylation processes ( Figure S3 ) are helpful for identifying fatty acids [ 62 , 63 ], the major constituents of the oil were detected as methyl or methyl esters derivatives. GC-Trace ultra-system (Thermo Co. USA) was used to analyze each of the studied fixed oils.…”

Section: Methodsmentioning

confidence: 99%

A Novel Microwave Hot Pressing Machine for Production of Fixed Oils from Different Biopolymeric Structured Tissues

Hindi,

Dawoud,

Ismail

et al. 2023

Polymers

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A microwave hot pressing machine (MHPM) was used to heat the colander to produce fixed oils from each of castor, sunflower, rapeseed, and moringa seed and compared them to those obtained using an ordinary electric hot pressing machine (EHPM). The physical properties, namely the moisture content of seed (MCs), the seed content of fixed oil (Scfo), the yield of the main fixed oil (Ymfo), the yield of recovered fixed oil (Yrfo), extraction loss (EL), six Efficiency of fixed oil extraction (Efoe), specific gravity (SGfo), refractive index (RI) as well as chemical properties, namely iodine number (IN), saponification value (SV), acid value (AV), and the yield of fatty acid (Yfa) of the four oils extracted by the MHPM and EHPM were determined. Chemical constituents of the resultant oil were identified using GC/MS after saponification and methylation processes. The Ymfo and SV obtained using the MHPM were higher than those for the EHPM for all four fixed oils studied. On the other hand, each of the SGfo, RI, IN, AV, and pH of the fixed oils did not alter statistically due to changing the heating tool from electric band heaters into a microwave beam. The qualities of the four fixed oils extracted by the MHPM were very encouraging as a pivot of the industrial fixed oil projects compared to the EHPM. The prominent fatty acid of the castor fixed oil was found to be ricinoleic acid, making up 76.41% and 71.99% contents of oils extracted using the MHPM and EHPM, respectively. In addition, the oleic acid was the prominent fatty acid in each of the fixed oils of sunflower, rapeseed, and moringa species, and its yield by using the MHPM was higher than that for the EHPM. The role of microwave irradiation in facilitating fixed oil extrusion from the biopolymeric structured organelles (lipid bodies) was protruded. Since it was confirmed by the present study that using microwave irradiation is simple, facile, more eco-friendly, cost-effective, retains parent quality of oils, and allows for the warming of bigger machines and spaces, we think it will make an industrial revolution in oil extraction field.

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Section: Methodsmentioning

confidence: 99%

A Novel Microwave Hot Pressing Machine for Production of Fixed Oils from Different Biopolymeric Structured Tissues

Hindi,

Dawoud,

Ismail

et al. 2023

Polymers

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“…Overcoming the upregulation of P-gp is considered as feasible treatment in drug-resistant epilepsy. Sebacic acid (SA) is a straight-chain, ten-carbon aliphatic dicarboxylic acid normally made from castor oil [97]. In a recently published study, it was reported that SA demonstrated antiseizure activities in MES-and s.c. PTZ-induced seizure models.…”

Section: Sebacic Acidmentioning

confidence: 99%

Identification of New Antiseizure Medication Candidates in Preclinical Animal Studies

Yang,

Wu,

Lai

et al. 2023

IJMS

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Epilepsy is a multifactorial neurologic disease that often leads to many devastating disabilities and an enormous burden on the healthcare system. Until now, drug-resistant epilepsy has presented a major challenge for approximately 30% of the epileptic population. The present article summarizes the validated rodent models of seizures employed in pharmacological researches and comprehensively reviews updated advances of novel antiseizure candidates in the preclinical phase. Newly discovered compounds that demonstrate antiseizure efficacy in preclinical trials will be discussed in the review. It is inspiring that several candidates exert promising antiseizure activities in drug-resistant seizure models. The representative compounds consist of derivatives of hybrid compounds that integrate multiple approved antiseizure medications, novel positive allosteric modulators targeting subtype-selective γ-Aminobutyric acid type A receptors, and a derivative of cinnamamide. Although the precise molecular mechanism, pharmacokinetic properties, and safety are not yet fully clear in every novel antiseizure candidate, the adapted approaches to design novel antiseizure medications provide new insights to overcome drug-resistant epilepsy.

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“…PA1210 is a semi‐biobased polyamide, and one of its raw materials, sebacic acid, is derived from the cleavage of castor oil. [ 34 ] Biobased monomers face challenges concerning the availability of raw materials and production costs. And the cracking by‐products of castor oil, fatty acids, have a variety of uses, including grease, lubricants, and surfactants.…”

Section: Introductionmentioning

confidence: 99%

Polyetheramine‐Type Semi‐Biobased Long‐Chain Polyamide 1210 Elastomer: Synthesis, Structure, and Unique Thermal Behavior

Chen,

Gong,

Zhao

et al. 2024

Macro Materials & Eng

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Biobased thermoplastic polyamide elastomers (TPAEs) have received increasing attention in both academia and industry. Here, a series of semi‐biobased long‐chain TPAEs are successfully synthesized via one‐step melt polymerization, employing polyamide 1210 (PA1210) and polyetheramines (PEAs) as hard and soft segments, respectively. The prepared TPAEs demonstrate excellent mechanical properties, energy dissipation capabilities, low density, good damping, high resilience, and low melting temperature. More interestingly, the properties of the TPAEs can be customized by adjusting the content and molecular weight of PEA. By varying the molecular weights of the PEAs, two different thermal behaviors can be observed in the prepared TPAEs. Specifically, PEA with low molecular weight has good compatibility with PA1210, leading to an increase in the conformation of the crystalline region and a significant decrease in melting temperature. Meanwhile, high molecular weight PEA causes strong phase separation with PA1210, leading to limited crystalline regions and inadequate physical cross‐linking, further resulting in suboptimal mechanical properties. This work provides new insights into the design and preparation of PEA‐type biobased long‐chain TPAEs.

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Design and Synthesis of Sebacic Acid from Castor Oil by New Alternate Route

Cited by 10 publications

References 26 publications

A Novel Microwave Hot Pressing Machine for Production of Fixed Oils from Different Biopolymeric Structured Tissues

A Novel Microwave Hot Pressing Machine for Production of Fixed Oils from Different Biopolymeric Structured Tissues

Identification of New Antiseizure Medication Candidates in Preclinical Animal Studies

Polyetheramine‐Type Semi‐Biobased Long‐Chain Polyamide 1210 Elastomer: Synthesis, Structure, and Unique Thermal Behavior

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