Identification of New Antiseizure Medication Candidates in Preclinical Animal Studies
Chih-Sheng Yang,
Man-Chun Wu,
Ming-Chi Lai
et al.
Abstract:Epilepsy is a multifactorial neurologic disease that often leads to many devastating disabilities and an enormous burden on the healthcare system. Until now, drug-resistant epilepsy has presented a major challenge for approximately 30% of the epileptic population. The present article summarizes the validated rodent models of seizures employed in pharmacological researches and comprehensively reviews updated advances of novel antiseizure candidates in the preclinical phase. Newly discovered compounds that demon… Show more
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