Design and Synthesis of Novel Magnetic Core−Shell Polymeric Particles

Ho, Kin Man; Li, Pei

doi:10.1021/la702887m

Cited by 78 publications

(38 citation statements)

References 39 publications

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“…Additionally, polymeric coatings have been engineered to enhance SPION pharmacokinetics, endosomal release, and tailored drug loading and release behaviors. To serve these coating functions, a diverse group of polymers have been investigated including PEG [81, 126, 127, 128, 129, 130, 131, 132], dextran [133, 134, 135, 136], chitosan [137, 138, 139, 140], PEI [104, 141, 142, 143, 144, 145], and phospholipids [145, 146, 147]. …”

Section: Fabrication Of Target-specific Magnetic Nanoparticles (Mnps)mentioning

confidence: 99%

Design and fabrication of magnetic nanoparticles for targeted drug delivery and imaging

Veiseh

Gunn

Zhang

2010

Advanced Drug Delivery Reviews

1,666

1,169

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Magnetic nanoparticles (MNPs) represent a class of non-invasive imaging agents that have been developed for magnetic resonance (MR) imaging. These MNPs have traditionally been used for disease imaging via passive targeting, but recent advances have opened the door to cellular-specific targeting, drug delivery, and multi-modal imaging by these nanoparticles. As more elaborate MNPs are envisioned, adherence to proper design criteria (e.g. size, coating, molecular functionalization) becomes even more essential. This review summarizes the design parameters that affect MNP performance in vivo, including the physicochemical properties and nanoparticle surface modifications, such as MNP coating and targeting ligand functionalizations that can enhance MNP management of biological barriers. A careful review of the chemistries used to modify the surfaces of MNPs is also given, with attention paid to optimizing the activity of bound ligands while maintaining favorable physicochemical properties.

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Section: Fabrication Of Target-specific Magnetic Nanoparticles (Mnps)mentioning

confidence: 99%

Design and fabrication of magnetic nanoparticles for targeted drug delivery and imaging

Veiseh

Gunn

Zhang

2010

Advanced Drug Delivery Reviews

1,666

1,169

View full text Add to dashboard Cite

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“…Mangeney et al reported about the bioreactivity of magnetic Fe 2 O 3 -PS/polypyrrole (PPy) core/shell particles [60]. Ho and Li [61] described magnetic core/shell particles consisting of hydrophobic PMMA cores with γ-Fe 2 O 3 nanoparticles inside. The PMMA cores were encapsulated with hydrophilic chitosan shells.…”

Section: Composite Typesmentioning

confidence: 99%

Polymer-Nanoparticle Composites: From Synthesis to Modern Applications

2010

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The addition of inorganic spherical nanoparticles to polymers allows the modification of the polymers physical properties as well as the implementation of new features in the polymer matrix. This review article covers considerations on special features of inorganic nanoparticles, the most important synthesis methods for ceramic nanoparticles and nanocomposites, nanoparticle surface modification, and composite formation, including drawbacks. Classical nanocomposite properties, as thermomechanical, dielectric, conductive, magnetic, as well as optical properties, will be summarized. Finally, typical existing and potential applications will be shown with the focus on new and innovative applications, like in energy storage systems.

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“…8b). Ho and Li [39] synthesized magnetic core-shell particles via copolymerization of methyl metacrylate from chitosan in the presence of vinyl-coated Fe 2 O 3 nanoparticles. They showed that the terminal double bonds on the vinyl-coated nanoparticles would allow copolymerization between the vinyl groups and methyl metacrylate monomer.…”

Section: Surface Characteristics Of the Nanoparticlesmentioning

confidence: 99%