Synthesis and cytotoxicity assessment of superparamagnetic iron–gold core–shell nanoparticles coated with polyglycerol

Jafari, Tahereh; Simchi, A.; Khakpash, Nasser

doi:10.1016/j.jcis.2010.01.038

Cited by 62 publications

(36 citation statements)

References 40 publications

(55 reference statements)

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“…[5,17,18,[21][22][23][24] This behavior is in marked contrast to that of noncarbonaceous materials, such as iron oxide, iron-gold, and CdTe (quantum dot), in which noncovalent bonds, such as ionic and coordinate bonds, are predominant. [14][15][16] To quantify the PG layer on the ND surface, we carried out elemental analysis of ND and ND-PG (Table 1). If all of the ND particles are assumed to have a spherical shape with a 30 nm diameter, each particle was calculated to consist of 2.5 10 6 C atoms.…”

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confidence: 99%

Chromatographic Separation of Highly Soluble Diamond Nanoparticles Prepared by Polyglycerol Grafting

et al. 2011

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Diamond nanoparticles, so-called nanodiamonds (NDs), are attracting growing attention, because they have the intrinsic characteristics of diamond together with the unique properties of nanometer-sized particles. In particular, biomedical applications of NDs have been investigated extensively owing to their low toxicity and amenability to various surface functionalizations. [1][2][3][4][5][6][7] One of the most promising applications of ND is biomedical imaging on the basis of nonbleaching fluorescence from the diamond core (nitrogen-vacancy, or N-V, center). [4,8,9] In such biomedical applications of ND, it should form a stable hydrosol in a physiological environment, as pointed out by Xing and Dai, [2] and Shenderova et al. [3] in their recent reviews.Although we successfully prepared a very stable hydrosol of ND functionalized with polyethylene glycol (PEG), [5] its solubility was not sufficient for biomedical applications, for example, as a platform for an imaging probe and drugdelivery system. To increase the solubility, we changed the molecular design and exchanged the linear polyethers PEG for hyperbranched polyols, because the hydroxy group is more hydrophilic than an ether group, and the hyperbranched structure can cover the nanoparticle surface much more densely than a linear chain. Polyglycerol (PG) was adopted as the hyperbranched polyol to be grafted onto the ND surface for the following three reasons: 1) PG shows high biocompatibility as well as high hydrophilicity, [10][11][12][13] 2) a PG layer can be readily constructed on the ND surface through ringopening multibranching polymerization of glycidol initiated at the functional groups on the ND surface, [14,15] and 3) PG can be functionalized further by derivatizing the periphery. [12,13] The recent use of PG for the functionalization of various nanoparticles with potential biological applications [14][15][16][17][18] prompted us to communicate our results. Herein, we report the preparation of PG-functionalized ND (ND-PG). Its extremely high solubility not only in pure water but also in buffer solutions enabled chromatographic separation of the NDs according to size. In view of cancer imaging, size control of nanoparticles is important because of enhanced permeability and retention (EPR) in solid tumors. [19] The ND used for PG functionalization, designated as ND30 herein, has a 30 nm median diameter and is prepared from bulk diamond synthesized by a static high-pressurehigh-temperature (HPHT) method. ND-PG was synthesized through ring-opening multibranching polymerization of glycidol at high temperature (Scheme 1). When the polymerization was initiated at the surface functional groups, such as hydroxy and carboxylic acid groups, the ND surface was covered with PG. However, PG without the ND core, designated as free PG, was also obtained as a side product through self-ring-opening polymerization of glycidol. To retard the side reaction initiated not from the ND surface but from glycidol, we examined the reaction conditions, including the solvent, t...

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confidence: 99%

Chromatographic Separation of Highly Soluble Diamond Nanoparticles Prepared by Polyglycerol Grafting

et al. 2011

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“…Nanotechnology has interfaced very closely in the past decade with drug delivery. 4,11,12 The size and shape of nanoparticles (NPs) are a critical component, since this affects their ability to navigate biological carriers in the body. The need for improved delivery systems motivated the development and application of nanofabrication technologies to be more effective DDS.…”

Section: Introductionmentioning

confidence: 99%

Drug Delivery Systems: Possibilities and Challenges

Spitler¹,

Zanganeh²,

Jafari³

et al. 2017

Drug Delivery Systems

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“…HPG was chosen as the hydrophilic polymer to be grafted onto SiO 2 NP-PCL for three main reasons: 1) HPG shows high biocompatibility as well as high hydrophilicity [16][17][18][19]; 2) the HPG layer reduces both the synthetic complexity and cost of the dispersant; 3) the branched nature of HPG should provide greater surface coverage. Recently, the functionalization of various nanoparticles with HPG has been reported for a range of biomedical applications [20][21][22][23]. HPG can be thought of as a hyperbranched analog of PEG, in that it exhibits the stability and biocompatibility of PEG, yet also possesses the compact structure and high end-group functionality associated with dendritic polymers.…”

Section: Introductionmentioning

confidence: 99%

Amphiphilic hyperbranched polyglycerol-block-polycaprolactone copolymer-grafted nanoparticles with improved encapsulation properties

Ejaz

Alb

Grayson

2016

Reactive and Functional Polymers

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Synthesis and cytotoxicity assessment of superparamagnetic iron–gold core–shell nanoparticles coated with polyglycerol

Cited by 62 publications

References 40 publications

Chromatographic Separation of Highly Soluble Diamond Nanoparticles Prepared by Polyglycerol Grafting

Chromatographic Separation of Highly Soluble Diamond Nanoparticles Prepared by Polyglycerol Grafting

Drug Delivery Systems: Possibilities and Challenges

Amphiphilic hyperbranched polyglycerol-block-polycaprolactone copolymer-grafted nanoparticles with improved encapsulation properties

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