Design and synthesis of new series of dipyrromethane-coumarin and porphyrin-coumarin derivatives: Excellent anticancer agents

Exploring the Expanding Frontiers: The Promising Role of Supramolecules in Advancing Cancer and Infectious Disease Therapy

“…After further evaluation at five dose levels, compound 6a showed enhanced antiproliferative activity and have been referred for advanced study by the Biological Evaluation Committee of NCI. These findings hold potential for the development of novel and effective anticancer therapies 46 .…”

“…Flow cytometry analysis of cell size showed that cells treated with 2 and 3 in HBSS shrank significantly. They also discovered that these transporters raise intracellular sodium chloride concentrations, increase cellular ROS levels, trigger mitochondrial cytochrome c release, and activate caspases 46 . Park et al, reported in a recent research that the ion transporter octafluorocalix [4]pyrrole Fig.…”

Evaluation of Cytotoxicity and Apoptosis Induced by Coumarin Hydrazide-Hydrazone Derivatives in Human Hepatocellular Carcinoma Cell Line

“…Furthermore, the strategy of combining 2 or more pharmacophores within a single molecular scaffold, known as molecular hybridization, is employed to enhance the pharmacokinetic and pharmacodynamic properties while reducing toxicity [11]. Through this strategy, numerous researchers have designed and synthesized coumarin hybrids with various bioactive molecules as anticancer agents [12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27] such as benzimidazole [12], benzothiazole [13], chalcones [14,15], dihydroartemisinin [16], dipyrromethene/porphyrin [17], isoxazoline [18], oxadiazole [19], piperazine [20], stilbene [21], thiazolyl-pyrazoline [22], uracil [23].…”

In Silico and In Vitro Studies of 4-Hydroxycoumarin-Based Heterocyclic Enamines as Potential Anti-Tumor Agents

“…The properties of coumarin derivatives can be tuned by introducing different electron-withdrawing and electron-donating groups. Therefore, the development of substituted heterocyclic enamines that can selectively pass the cell barriers of tumor cells and interact with cell proteins is an interesting area [24]. Although many cell proteins can be targeted to control cell growth, the selective targeting of the CDK-8 enzyme can be a good strategy.…”