Design and Synthesis of Matrix Metalloprotease Photoaffinity Trimodular Probes

Abstract

To explore the molecular mechanism of the matrix metalloproteinases (MMPs) in tumor processes, two photoaffinity trimodular probes were designed and synthesized based on the structure activity relationship and the following photoaffinity labelling experiments afforded positive results.

Probing the metalloproteome: an 8-mercaptoquinoline motif enriches minichromosome maintenance complex components as significant metalloprotein targets in live cells

“…6). [4][5][6][7][8][10][11][12][13][14][15][50][51][52][53] An interesting outcome of the metalloprotein hits discussed above show that 8MQ may also chelate metalloproteins bearing non-zinc metal ion cofactors.…”

Hyperbranched Macromolecules: From Synthesis to Applications

“…In the bio-imaging field, HM-probe-conjugates with good water solubility and available functional groups are good solutions to problems associated with low quantum yield and poor specificity. Zhu and Yan grafted fluorescein isothiocyanate on peripheral hyperbranched polysulfonamine (HPSA) through the reaction of isothiocyanate and a primary amino group [ 128 , 129 ]. With low cytotoxicity and good serum compatibility, the HPSA-probe conjugate can be used for bio-imaging or for tracking cells [ 125 ].…”