Design and Synthesis of Fluorescent Sensors for Zinc Ion Derived from 2‐Aminobenzamide

Abstract

Four novel Zn2+ fluorescent sensors have been designed with N,N‐bis(2‐pyridylmethyl)ethylenediamine as chelator and 2‐aminobenzamide as fluorophore. These sensors were prepared in two or three steps from readily available starting materials. Of the four designed sensors, ZnABA was found to be the most efficient Zn2+‐specific fluorescent probe and has good solubility in biological buffer, a large Stokes shift (186 nm), a high off–on fluorescence response (16‐fold enhancement), and distinct selectivity towards Zn2+ over other metal ions. Our results have demonstrated an excellent linear relationship between the fluorescence intensity of ZnABA and the Zn2+ concentration from 0 to 10 μM, which indicates that ZnABA has the potential to be used for the quantitative determination of Zn2+ in an aqueous environment.

Evaluation of N-Alkyl-bis-o-aminobenzamide Receptors for the Determination and Separation of Metal Ions by Fluorescence, UV-Visible Spectrometry and Zeta Potential

“…Additionally, aminobenzamide derivatives are used as pharmacological inhibitors on Parkinson’s disease [12], human cancer cells [13], and neurobehavioral and neurochemical anomalies [14]. The development of fluorescent sensors has received appreciable attention for detecting biologically important ions, either cations or anions [15].…”