Design and studies of multiple mechanism of anti-Candida activity of a new potent Trp-rich peptide dendrimers

Zielińska, Paulina; Staniszewska, Monika; Bondaryk, Małgorzata; Koronkiewicz, Mirosława; Urbańczyk‐Lipkowska, Zofia

doi:10.1016/j.ejmech.2015.10.013

Cited by 34 publications

(23 citation statements)

References 43 publications

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“…Consequently, this peptide prompted design of a group of eight new, structurally variable peptide dendrimers covered with several copies of bare or N -methylated tryptophanes and their subsequent evaluation confirmed multiple mode of action of this group of compounds as well [ 228 ].…”

Section: Antifungal Peptidesmentioning

confidence: 99%

Natural Antimicrobial Peptides as Inspiration for Design of a New Generation Antifungal Compounds

Bondaryk

Staniszewska

Zielińska

et al. 2017

JoF

Self Cite

100

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Invasive fungal infections are associated with high mortality rates, despite appropriate antifungal therapy. Limited therapeutic options, resistance development and the high mortality of invasive fungal infections brought about more concern triggering the search for new compounds capable of interfering with fungal viability and virulence. In this context, peptides gained attention as promising candidates for the antimycotics development. Variety of structural and functional characteristics identified for various natural antifungal peptides makes them excellent starting points for design novel drug candidates. Current review provides a brief overview of natural and synthetic antifungal peptides.

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Section: Antifungal Peptidesmentioning

confidence: 99%

Natural Antimicrobial Peptides as Inspiration for Design of a New Generation Antifungal Compounds

Bondaryk

Staniszewska

Zielińska

et al. 2017

JoF

Self Cite

100

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“…More recently, the same team synthesized a bunch of novel peptide dendrimers rich in Trp and with an amphiphilic fold, variable in structure and hydrophobicity, and tested their activity versus various Candida species and strains. A specific lead, dendrimer 14, containing four Trp residues and a dodecyl tail, was found to be particularly active, causing membrane damage at fungicidal concentration (16 μg/mL) and inducing both cell death in Candida cells by both apoptosis and necrosis [43]. Confocal microscopy observations showed that dendrimer 14 affects the morphogenesis and biofilm viability of Candida , destroying mature biofilm by acting negatively on the germination and reducing hyphae formation and also inhibited the biofilm formation [43].…”

Section: Viruses and Fungal Pathogens As Targetsmentioning

confidence: 99%

“…A specific lead, dendrimer 14, containing four Trp residues and a dodecyl tail, was found to be particularly active, causing membrane damage at fungicidal concentration (16 μg/mL) and inducing both cell death in Candida cells by both apoptosis and necrosis [43]. Confocal microscopy observations showed that dendrimer 14 affects the morphogenesis and biofilm viability of Candida , destroying mature biofilm by acting negatively on the germination and reducing hyphae formation and also inhibited the biofilm formation [43]. Another compound with a branched structure, D186, containing four Trp residues, exhibited an anti- Candida action mode associated with a reduced virulence in terms of adhesive ability and pathogenic potential related to the expression of the SAP5 gene and morphogenetic factors EFG1 and CPH1 [44].…”

Section: Viruses and Fungal Pathogens As Targetsmentioning

confidence: 99%

Antimicrobial Dendrimeric Peptides: Structure, Activity and New Therapeutic Applications

Scorciapino

Serra

Manzo

et al. 2017

IJMS

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Microbial resistance to conventional antibiotics is one of the most outstanding medical and scientific challenges of our times. Despite the recognised need for new anti-infective agents, however, very few new drugs have been brought to the market and to the clinic in the last three decades. This review highlights the properties of a new class of antibiotics, namely dendrimeric peptides. These intriguing novel compounds, generally made of multiple peptidic sequences linked to an inner branched core, display an array of antibacterial, antiviral and antifungal activities, usually coupled to low haemolytic activity. In addition, several peptides synthesized in oligobranched form proved to be promising tools for the selective treatment of cancer cells.

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“…One dendrimer of this type showed synergistic effect against Acanthamoeba polyphaga when combined with chlorhexidine digluconate [ 26 ]. Dendrimers have also been used as antifungals [ 27 ], as delivery systems for commercial antifungals [ 28 ], and are associated with commercial biocides to enhance their solubility [ 29 , 30 ] and/or activity [ 30 , 31 ].…”

Section: Introductionmentioning

confidence: 99%

In Vitro Activity of Carbosilane Cationic Dendritic Molecules on Prevention and Treatment of Candida Albicans Biofilms

et al. 2020

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Candida spp. are one of the most common fungal pathogens. Biofilms formed by Candidaalbicans offer resistance mechanisms against most antifungal agents. Therefore, development of new molecules effective against these microorganisms, alone or in combination with antifungal drugs, is extremely necessary. In the present work, we carried out a screening process of different cationic carbosilane dendritic molecules against C. albicans. In vitro activity against biofilm formation and biofilms was tested in both Colección Española de Cultivos Tipo (CECT) 1002 and clinical C. albicans strains. Cytotoxicity was studied in human cell lines, and biofilm alterations were observed by scanning electron microscopy (SEM). Antifungal activity of the carbosilane dendritic molecules was assessed by monitoring cell viability using both established and novel cell viability assays. One out of 14 dendritic molecules tested, named BDSQ024, showed the highest activity with a minimum biofilm inhibitory concentration (MBIC) for biofilm formation and a minimum biofilm damaging concentration (MBDC) for existing biofilm of 16–32 and 16 mg/L, respectively. Synergy with amphotericin (AmB) and caspofungin (CSF) at non-cytotoxic concentrations was found. Therefore, dendritic compounds are exciting new antifungals effective at preventing Candida biofilm formation and represent a potential novel therapeutic agent for treatment of C. albicans infection in combination with existing clinical antifungals.

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Design and studies of multiple mechanism of anti-Candida activity of a new potent Trp-rich peptide dendrimers

Cited by 34 publications

References 43 publications

Natural Antimicrobial Peptides as Inspiration for Design of a New Generation Antifungal Compounds

Natural Antimicrobial Peptides as Inspiration for Design of a New Generation Antifungal Compounds

Antimicrobial Dendrimeric Peptides: Structure, Activity and New Therapeutic Applications

In Vitro Activity of Carbosilane Cationic Dendritic Molecules on Prevention and Treatment of Candida Albicans Biofilms

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