Design and simulation of a novel electrostatic peristaltic micromachined pump for drug delivery applications

Teymoori, Mir Majid; Abbaspour-Sani, Ebrahim

doi:10.1016/j.sna.2004.06.025

Cited by 202 publications

(107 citation statements)

References 7 publications

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“…Analytical and numerical calculations of static diaphragm deflections and pumping stroke volumes have been considered for piezoelectric peristaltic micropumps [25]. Also restricted to static characteristics, piezoelectric [4] and electrostatic [26] peristaltic pumps have been modeled by assuming the flow rate to be proportional to the actuation frequency and stroke volume, which is determined from the diaphragm motion by ignoring its interaction with fluid flow. More recently, a lumped-parameter analysis has been reported for diaphragmbased micropumps working peristaltically using active valves driven by general actuation schemes [27].…”

Section: Introductionmentioning

confidence: 99%

Dynamic simulation of a peristaltic micropump considering coupled fluid flow and structural motion

Lin¹,

Yang²,

Xie³

et al. 2006

J. Micromech. Microeng.

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This paper presents lumped-parameter simulation of dynamic characteristics of peristaltic micropumps. The pump consists of three pumping cells connected in series, each of which is equipped with a compliant diaphragm that is electrostatically actuated in a peristaltic sequence to mobilize the fluid. Diaphragm motion in each pumping cell is first represented by an effective spring subjected to hydrodynamic and electrostatic forces. These cell representations are then used to construct a system-level model for the entire pump, which accounts for both cell-and pump-level interactions of fluid flow and diaphragm vibration. As the model is based on first principles, it can be evaluated directly from the device's geometry, material properties and operating parameters without using any experimentally identified parameters. Applied to an existing pump, the model correctly predicts trends observed in experiments. The model is then used to perform a systematic analysis of the impact of geometry, materials and pump loading on device performance, demonstrating its utility as an efficient tool for peristaltic micropump design.

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Section: Introductionmentioning

confidence: 99%

Dynamic simulation of a peristaltic micropump considering coupled fluid flow and structural motion

Lin¹,

Yang²,

Xie³

et al. 2006

J. Micromech. Microeng.

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show abstract

“…48,49 A dual diaphragm electrostatic micropump was developed, and it achieved a flow rate of 30 µL/min at a frequency of 30 Hz and operating voltage of 160 V. 49 Moreover, design and simulation of an electrostatic peristaltic micropump was reported for drug delivery applications. 50 The micropump was designed to satisfy most of the drug delivery requirements, but the actual fabrication and testing of the micropump was not reported. The advantages of electrostatic micropumps are low power consumption and fast response time.…”

Section: Mechanical Approachmentioning

confidence: 99%

Microfluidic Systems for Diagnostic Applications: A Review

Lei

2012

SLAS Technology

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Because of intensive developments in recent years, the microfluidic system has become a powerful tool for biological analysis. Entire analytic protocols including sample pretreatment, sample/reagent manipulation, separation, reaction, and detection can be integrated into a single chip platform. A lot of demonstrations on the diagnostic applications related to genes, proteins, and cells have been reported because of their advantages associated with miniaturization, automation, sensitivity, and specificity. The aim of this article is to review recent developments in microfluidic systems for diagnostic applications. Based on the categories of various fluid-manipulating mechanisms and biological detection approaches, in-depth discussion of the microfluidic-based diagnostic systems is provided. Moreover, a brief discussion on materials and manufacturing techniques will be included. The current excellent integration of microfluidic systems and diagnostic applications suggests a solid foundation for the development of practical point-of-care devices.

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“…1932-1058/2012/6(1)/014118/16/$30.00 V C 2012 American Institute of Physics 6, 014118-1 microfluidic applications by utilizing piezoelectric, [11][12][13][14] electrostatic, 15 pneumatic, 16,17 or magnetic effects. 18 Although these on-chip pumps increase the device portability, integrating the pumping components (e.g., diaphragms, actuators, valves, and heaters) on the device significantly increases the fabrication complexity and device cost.…”

Section: Introductionmentioning

confidence: 99%

A “place n play” modular pump for portable microfluidic applications

Li¹,

Luo²,

Chen³

et al. 2012

Biomicrofluidics

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This paper presents an easy-to-use, power-free, and modular pump for portable microfluidic applications. The pump module is a degassed particle desorption polydimethylsiloxane (PDMS) slab with an integrated mesh-shaped chamber, which can be attached on the outlet port of microfluidic device to absorb the air in the microfluidic system and then to create a negative pressure for driving fluid. Different from the existing monolithic degassed PDMS pumps that are generally restricted to limited pumping capacity and are only compatible with PDMS-based microfluidic devices, this pump can offer various possible configures of pumping power by varying the geometries of the pump or by combining different pump modules and can also be employed in any material microfluidic devices. The key advantage of this pump is that its operation only requires the user to place the degassed PDMS slab on the outlet ports of microfluidic devices. To help design pumps with a suitable pumping performance, the effect of pump module geometry on its pumping capacity is also investigated. The results indicate that the performance of the degassed PDMS pump is strongly dependent on the surface area of the pump chamber, the exposure area and the volume of the PDMS pump slab. In addition, the initial volume of air in the closed microfluidic system and the cross-linking degree of PDMS also affect the performance of the degassed PDMS pump. Finally, we demonstrated the utility of this modular pumping method by applying it to a glass-based microfluidic device and a PDMS-based protein crystallization microfluidic device. V C 2012 American Institute of Physics. [http://dx

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Design and simulation of a novel electrostatic peristaltic micromachined pump for drug delivery applications

Cited by 202 publications

References 7 publications

Dynamic simulation of a peristaltic micropump considering coupled fluid flow and structural motion

Dynamic simulation of a peristaltic micropump considering coupled fluid flow and structural motion

Microfluidic Systems for Diagnostic Applications: A Review

A “place n play” modular pump for portable microfluidic applications

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