Design and performance of a system to control concentrations of common gaseous air pollutants within environmental laboratories used for human exposure studies

Glover, Donald E.; Berntsen, Jon; Crider, Walter L.; Strong, Arthur A.

doi:10.1080/10934528109375001

Cited by 18 publications

(4 citation statements)

References 2 publications

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“…Each subject then participated in one exposure session to 0.42 ppm O 3 at normal temperature (22 • C) and relative humidity (40%). Preexposure procedures for subjects and chamber description are as detailed previously (Glover et al, 1981;Hazucha et al, 2003). During the 90-min exposure to O 3 , subjects alternated 20 min of exercise at the load determined during the training session with 10 min of rest.…”

Section: Methodsmentioning

confidence: 99%

Acute Pulmonary Function Response to Ozone in Young Adults As a Function of Body Mass Index

Bennett

Hazucha

Folinsbee

et al. 2007

Inhalation Toxicology

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Recent studies have shown enhanced responsiveness to ozone in obese mice. Adiposity has not been examined as a possible modulator of ozone response in humans. We therefore examined the relationship between body mass index and the acute spirometric response to ozone (O(3)) exposure among 197 nonasthmatic young adults (aged 18-35 yr) studied in our human exposure facility from 1992 to 1998. Each subject had been exposed to 0.42 ppm O(3) for 1.5 h with intermittent exercise designed to produce a minute ventilation of 20 L/min/m(2) body surface area (BSA). Spirometry (pulmonary function) was measured pre- and immediately postexposure to determine acute ozone-induced changes. The decrement in forced expiratory volume in 1s (Delta FEV1) as percent of baseline was significantly correlated with BMI, r = -0.16, p = .03, with a slightly stronger correlation in women (n = 75), r = -0.22, p = .05, and no significant correlation in men. BMI had a greater range in women than in men in our study. In women greater ozone-induced decrements were seen in overweight (BMI > 25 kg/m(2)) than in normal weight (BMI 18.5 to 25 kg/m(2)), and in normal weight than in underweight (BMI < 18.5 kg/m(2)) for all spirometric variables considered (p trend

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Section: Methodsmentioning

confidence: 99%

Acute Pulmonary Function Response to Ozone in Young Adults As a Function of Body Mass Index

Bennett

Hazucha

Folinsbee

et al. 2007

Inhalation Toxicology

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“…During O 3 exposures, nitric oxide, nitrogen dioxide, and sulfur dioxide concentrations were typically Ͻ0.02, 0.005, and 0.005 ppm, respectively. A detailed description of the exposure chambers was published by Glover et al (13).…”

Section: Methodsmentioning

confidence: 99%

Distribution and reproducibility of spirometric response to ozone by gender and age

Hazucha

Folinsbee

Bromberg

2003

Journal of Applied Physiology

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Subjects were healthy nonsmoking men (n = 146) and women (n = 94) 18-60 yr old. Initially, each subject was exposed for 1.5 h to 0.42 ppm O3. Forty-seven individuals were later reexposed twice, 1 wk to several months apart, to 0.4 ppm O3. Intermittent exercise utilized in all exposures was adjusted to produce an O3 dose of 560 ppm x l/m2 body surface area. The post-O3 percent change in forced-expiratory volume in 1 s (delta%FEV1) decrements of young (18-35 yr) and middle-aged (36-60 yr) men and women differed significantly (P < 0.05) from normal distribution with values skewed toward larger decrements in younger subjects. The mean delta%FEV1 rates were -16.3%, -16.6%, -11.6%, and -6.4%, respectively. The rate of decline with age was 2.5 times higher in young women compared with young men (P < 0.05). This pattern was reversed in the middle-age cohort. Our data support earlier reports of no significant difference in spirometric response to O3 between young men and women. The data also confirm that large FEV1 decrements after O3 exposure are mostly confined to younger individuals that also show much greater variance in response to repeated exposures than the middle-aged subjects. The majority of subjects remained in their initial category of O3 sensitivity on retesting after various time lapses. The r value (Spearman) between the first and second and first and third exposure response ranged from 0.544 to 850, depending on classification. However, the mean delta%FEV1 differed by as much as six percentage points between exposure days. The yearly loss of responsiveness (0.2% to 0.7%/year) with progressing age determined by cross-sectional analyses was substantially smaller.

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“…Ozone, produced by passing filtered air under ultraviolet (UV) lights, passed into the chamber from ducts in the ceiling and passed out through uniformly distributed holes in the floor. A detailed description of the chamber and the ozone-generating, delivery, monitoring, and control systems has been previously published (8,9). The chamber was comparable to a typical living room (4 X 6 X 3.2 m) and allowed the participants to conduct normal activities, including walking, reading, typing, and watching TV.…”

Section: Methodsmentioning

confidence: 99%

Evaluation of the Harvard Ozone Passive Sampler on Human Subjects Indoors

Liu¹,

Olson²,

Allen³

et al. 1994

Environ. Sci. Technol.

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Design and performance of a system to control concentrations of common gaseous air pollutants within environmental laboratories used for human exposure studies

Cited by 18 publications

References 2 publications

Acute Pulmonary Function Response to Ozone in Young Adults As a Function of Body Mass Index

Acute Pulmonary Function Response to Ozone in Young Adults As a Function of Body Mass Index

Distribution and reproducibility of spirometric response to ozone by gender and age

Evaluation of the Harvard Ozone Passive Sampler on Human Subjects Indoors

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