Design and optimization of hydrodynamically balanced oral in-situ gel of lamotrigine

Aim: Ivabradine hydrochloride is a hyperpolarized activated channel blocker used for symptomatic treatment of chronic angina pectoris. However, due to its short half-life it is rapidly eliminated from systemic circulation. Materials & methods: Floating in situ gel was formulated using sodium alginate and HPMC K 100 M by pH induced ion gelation technique employing 32 factorial design for optimization and evaluated. Results: The in situ formulation remained buoyant in gastric environment for 12 h. Optimized formulation sustained and prolonged drug release in comparison with marketed product. Kinetic analysis of drug release indicated non fickian mechanism. Short term stability studies showed no significant changes indicating good formulation stability. Conclusion: Formulated in situ solution shows potential effective sustained release over a prolonged period of time.

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Formulation and Evaluation of Lamotrigine Loaded Nanosponges

Satpathy¹,

Chaubey²,

Brahma³

et al. 2022

RJPT

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The main purpose of this investigation study is to fabricate nanosponges with good entrapment efficiency and percentage of yield to enhance the solubility and dissolution rate of poorly water soluble antiepileptic molecules of Lamotrigine, which belongs to BCS - II class. Lamotrigine nanosponges were prepared using emulsion solvent diffusion technique and the immediate release tablets of lamotrigine nanosponges were prepared by direct compression method. Nanosponges were formulated using different polymers ratio like EC and PVA. The optimized batch containing ratio 2:1:2 of drug, ethyl cellulose and PVA shows maximum entrapment efficiency and percentage of yield. The optimized nanosponges of lamotrigine (F1) were subjected for Practical yield, drug content, Saturation solubility, zeta potential, Fourier transform Infrared spectroscopy (FTIR), Differential Scanning Calorimetry (DSC) and Scanning electron microscopy(SEM). The optimized formulations (F1) of nanosponge based immediate release tablets compression parameters were also studied. The In-vitro dissolution was carried out by USP apparatus type II (Paddle Method) with 900 ml of 0.1 N HCl at 50 rpm. At definite time intervals, 5 ml of the receptor fluid were withdrawn, filtered and analyzed spectro-photometrically at wave length 265 nm. The compressed lamotrigine nanosponge shows 99.7% at the end of dissolution and it follows first order kinetics and best fit with Higuchi’s model. In this research solubility and dissolution demonstrated for nanosponge formulation.

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Design and optimization of hydrodynamically balanced oral in-situ gel of lamotrigine

Cited by 6 publications

References 7 publications

Design and Development of Novel Floating In Situ Gel of Amoxicillin for the Treatment of Peptic Ulcer Disease Caused by Helicobacter pylori

Design and Development of Novel Floating In Situ Gel of Amoxicillin for the Treatment of Peptic Ulcer Disease Caused by Helicobacter pylori

Formulation, Optimization and Validation of Floating Oral In Situ Gel of Ivabradine Hydrochloride

Formulation and Evaluation of Lamotrigine Loaded Nanosponges

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