Design and manufacturing of monodisperse and malleable phytantriol-based cubosomes for drug delivery applications

Malheiros, Barbara; Castro, Raphael Dias de; Lotierzo, Mayra C.G.; Casadei, Bruna Renata; Barbosa, Leandro R.S.

doi:10.1016/j.jddst.2020.102149

Cited by 9 publications

(17 citation statements)

References 55 publications

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“…The increase in concentration by 87% in water and 23% in PBS could be due to the breaking of larger particles (4500 nm) into smaller ones. 140 The nature of cubosome precursors may also influence the final stability of cubosomes. According to Spicer et al, the hydrotrope dilution process from liquid precursors produces cubosomes that are smaller and have more stability.…”

Section: Stabilitymentioning

confidence: 99%

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Cubosomes as an emerging platform for drug delivery: a review of the state of the art

et al. 2022

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Section: Stabilitymentioning

confidence: 99%

“…The increase in concentration by 87% in water and 23% in PBS could be due to the breaking of larger particles (>500 nm) into smaller ones. 140…”

Section: Cubosomes – a Potential Vehicle For Drug Deliverymentioning

confidence: 99%

Cubosomes as an emerging platform for drug delivery: a review of the state of the art

et al. 2022

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“…PHYT has physicochemical properties similar to GMO but with a nearly higher resistance to hydrolysis because of the absence of ester bonds and the existence of saturated phytanyl backbone in comparison to GMO . PHYT is biocompatible and forms a Pn 3 m cubic phase in excess water but GMO dispersions form the H 2 phase, either alone or coexisting with Pn 3 m cubic phase . PHYT-based cubosomes and hexosomes can sustain the release of specially hydrophilic bioactives, implying suitability as a unique sustained delivery vehicle.…”

Section: Composition Of Cubosomes and Hexosomesmentioning

confidence: 99%

“…26 PHYT is biocompatible and forms a Pn3m cubic phase in excess water but GMO dispersions form the H 2 phase, either alone or coexisting with Pn3m cubic phase. 27 PHYT-based cubosomes and hexosomes can sustain the release of specially hydrophilic bioactives, implying suitability as a unique sustained delivery vehicle. A comparative study of GMO and PHYT cubosomes loaded with oridonin has been performed, showing a higher bioavailability and longer shelf life with PHYT cubosomes.…”

Section: ■ Introductionmentioning

confidence: 99%

Cubosomes and Hexosomes as Novel Nanocarriers for Bioactive Compounds

Tan

Hosseini

Jafari

2022

J. Agric. Food Chem.

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Cubosomes and hexosomes are nanostructured liquid crystalline particles, known as biocompatible nanocarriers for drug delivery. In recent years, there has been good interest in using cubosomes and hexosomes for the delivery of bioactive compounds in functional foods. These systems feature thermodynamic stability, encapsulate both hydrophobic and hydrophilic substances, and have a high tolerance to environmental stresses and potential for controlled release. This review outlines the recent advances in cubosomes and hexosomes in the food industry, focusing on their structure, composition, formation mechanisms, and factors influencing phase transformation between cubosomes and hexosomes. The potential applications especially for the bioactive delivery are presented. The integration of cubosomes and hexosomes with other emerging encapsulation technologies such as surface coating, gelation, and incorporation of polymers are also discussed.

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“…1. With further optimization of conditions, it might be possible to get monodispersed particles; monodispersed particles can be also obtained by postpreparation treatment, e.g., extrusion using membranes 56,61 of the desired pore size. 2.…”

Section: Limitation Of the Electroformation Techniquementioning

confidence: 99%

Electroformation of Particulate Emulsions Using Lamellar and Nonlamellar Lipid Self-Assemblies

Bailey¹,

Prabhakaran²,

Vishwapathi³

et al. 2021

Langmuir

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We report on the development of an electroformation technique for the preparation of particulate (particle-based) emulsions. These oil-in-water (here, lipid phase acts as an "oil") emulsions were prepared using nonlamellar lipid phases. Such emulsion particles offer high hydrophobic volumes compared to conventional lipid particles based on lamellar phases (vesicles/liposomes). In addition, the tortuous internal nanostructure contributes through greater surface area per volume of lipid particles allowing an enhanced loading of payloads. The electroformation method makes use of a capacitor formed from two indium tin oxide coated conductive glass surfaces separated by a dielectric aqueous medium. This capacitor setup is enclosed in a custom-designed 3Dprinted unit. Lipid molecules, deposited on conductive surfaces, self-assemble into a nanostructure in the presence of an aqueous medium, which when subjected to an alternating current electric field forms nano-and/or microparticles. Optical microscopy, dynamic light scattering, and small-angle X-ray scattering techniques were employed for micro-and nanostructural analyses of electroformed particles. With this method, it is possible to produce particulate emulsions at a very low (e.g., 0.0005 wt % or 0.5 mg/mL) lipid concentration. We demonstrate an applicability of the electroformation method for drug delivery by preparing lipid particles with curcumin, which is a highly important but water-insoluble medicinal compound. As the method employs gentle conditions, it is potentially noninvasive for the delivery of delicate biomolecules and certain drugs, which are prone to decomposition or denaturation due to the high thermomechanical energy input and/or nonaqueous solvents required for existing methods.

show abstract

Design and manufacturing of monodisperse and malleable phytantriol-based cubosomes for drug delivery applications

Cited by 9 publications

References 55 publications

Cubosomes as an emerging platform for drug delivery: a review of the state of the art

Cubosomes as an emerging platform for drug delivery: a review of the state of the art

Cubosomes and Hexosomes as Novel Nanocarriers for Bioactive Compounds

Electroformation of Particulate Emulsions Using Lamellar and Nonlamellar Lipid Self-Assemblies

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