Design and manufacturing challenges of optogenetic neural interfaces: a review

Goncalves, S. B.; Ribeiro, J. F.; Silva, A. F.; Costa, Rui M.; Correia, J. H.

doi:10.1088/1741-2552/aa7004

Cited by 70 publications

(56 citation statements)

References 145 publications

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“…Microfabrication methods present a means to miniaturize the functions of larger probe designs while directly integrating optical elements into a single device. Reviews on optogenetics techniques have been published recently which outline the progress made in this field . In this section, we select the particular work that may be beneficial to microfabricated neurochemical probes.…”

Section: Potential For Optical Integrationsupporting

confidence: 93%

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Microfabricated Probes for Studying Brain Chemistry: A Review

2018

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Probe techniques for monitoring in vivo chemistry (e.g., electrochemical sensors and microdialysis sampling probes) have significantly contributed to a better understanding of neurotransmission in correlation to behaviors and neurological disorders. Microfabrication allows construction of neural probes with high reproducibility, scalability, design flexibility, and multiplexed features. This technology has translated well into fabricating miniaturized neurochemical probes for electrochemical detection and sampling. Microfabricated electrochemical probes provide a better control of spatial resolution with multisite detection on a single compact platform. This development allows the observation of heterogeneity of neurochemical activity precisely within the brain region. Microfabricated sampling probes are starting to emerge that enable chemical measurements at high spatial resolution and potential for reducing tissue damage. Recent advancement in analytical methods also facilitates neurochemical monitoring at high temporal resolution. Furthermore, a positive feature of microfabricated probes is that they can be feasibly built with other sensing and stimulating platforms including optogenetics. Such integrated probes will empower researchers to precisely elucidate brain function and develop novel treatments for neurological disorders.

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Section: Potential For Optical Integrationsupporting

confidence: 93%

“…Reviews on optogenetics techniques have been published recently which outline the progress made in this field. [189][190][191][192] In this section, we select the particular work that may be beneficial to microfabricated neurochemical probes.…”

Section: Potential For Optical Integrationmentioning

confidence: 99%

Microfabricated Probes for Studying Brain Chemistry: A Review

2018

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“…Optogenetics is another area of growing interest, where light‐stimulated cell behavior (typically neurons) is exploited for various purposes . For the multidisciplinary field, initial efforts have focused on the implementation and biological understanding.…”

Section: Progress Summarymentioning

confidence: 99%

“…51 Optogenetics is another area of growing interest, where light-stimulated cell behavior (typically neurons) is exploited for various purposes. [53][54][55] For the multidisciplinary field, initial efforts have focused on the implementation and biological understanding. Recently, people started to address the need for diversification and optimization of light sources, especially for in vivo systems where very strict materials, physical, and physiological constraints arise.…”

Section: Display As a Stimulation And Treatment Toolmentioning

confidence: 99%

Display meets biology: A vision for ubiquitous healthcare platforms

2019

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Ever‐increasing demand for a healthy and sustainable life has been a traditional motivation behind state‐of‐the‐art medicines and precision diagnosis tools. Nowadays, the ultra‐connectivity and data‐centric initiatives that underpin the future Internet of Things is seen as another major driver of electronically enriched, highly customizable healthcare platforms. Especially, the information display technology, which already enjoys its position as an all‐round player in consumer electronics is poised to broaden its territory by envisioning a range of bio‐related features. In this review, the rising opportunities for next‐generation display‐based biotechnology and healthcare systems are critically assessed in light of recent literature. Clearly, smart combination of new materials, devices, and integration strategies has given rise to highly promising prototypes, and this article aims at highlighting some of these examples. Despite such progress, it is still unclear whether the resultant technologies will make a measurable impact in the near future, given both their own scientific limits and the lack of proper business model. In this regard, the final part of this contribution is dedicated to emergent challenges as well as development solutions that this potentially disruptive innovation may need to consider.

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“…Figure compares conventional bulk biomedical electronics and flexible/stretchable electronics with injectable biomedical electronics, in terms of their implantation techniques, clinical uses, and postsurgical conditions. Explored strategies for injectable biomedical device developments involve controlling thickness and width for avoiding tissue damage, and stiffness and length for precise targeting 32–38. The applications of injectable biomedical devices broadly range from brain sciences to percutaneous therapies, reading vital clinical signs, and healing diseases without major surgical procedures.…”

Section: Introductionmentioning

confidence: 99%

Injectable Biomedical Devices for Sensing and Stimulating Internal Body Organs

et al. 2020

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The rapid pace of progress in implantable electronics driven by novel technology has created devices with unconventional designs and features to reduce invasiveness and establish new sensing and stimulating techniques. Among the designs, injectable forms of biomedical electronics are explored for accurate and safe targeting of deep‐seated body organs. Here, the classes of biomedical electronics and tools that have high aspect ratio structures designed to be injected or inserted into internal organs for minimally invasive monitoring and therapy are reviewed. Compared with devices in bulky or planar formats, the long shaft‐like forms of implantable devices are easily placed in the organs with minimized outward protrusions via injection or insertion processes. Adding flexibility to the devices also enables effortless insertions through complex biological cavities, such as the cochlea, and enhances chronic reliability by complying with natural body movements, such as the heartbeat. Diverse types of such injectable implants developed for different organs are reviewed and the electronic, optoelectronic, piezoelectric, and microfluidic devices that enable stimulations and measurements of site‐specific regions in the body are discussed. Noninvasive penetration strategies to deliver the miniscule devices are also considered. Finally, the challenges and future directions associated with deep body biomedical electronics are explained.

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Design and manufacturing challenges of optogenetic neural interfaces: a review

Abstract: Overall, this review aims at presenting a helpful guidance to the engineering and design of optical microsystems for optogenetic applications.

Cited by 70 publications

References 145 publications

Microfabricated Probes for Studying Brain Chemistry: A Review

Microfabricated Probes for Studying Brain Chemistry: A Review

Display meets biology: A vision for ubiquitous healthcare platforms

Injectable Biomedical Devices for Sensing and Stimulating Internal Body Organs

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