Design and In Vitro Evaluation of Novel Sustained-Release Double-Layer Tablets of Lornoxicam: Utility of Cyclodextrin and Xanthan Gum Combination

Hamza, Yassin El-Said; Aburahma, Mona Hassan

doi:10.1208/s12249-009-9336-9

Cited by 38 publications

(18 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The results showed that hydroxypropyl-β-cyclodextrin with Hydroxypropylcellulose can serve as immediate release carrier along with enhancing the oral bioavailability. 36 Hamza et al 37 develop double-layer tablets of lornoxicam by direct compression method. An amorphous, freeze-dried inclusion complex of lornoxicam with hydroxypropyl-β-cyclodextrin was present in 1:2 (drug/cyclodextrin) molar ratio in development of fast-release layer to enhance the dissolution of lornoxicam in the stomach and to assure rapid onset of its analgesic effect whereas, the sustained release layer was formed by using Xanthan gum.…”

Section: Figure 1 Depicts the Guest-host Inclusion Complexes Formationmentioning

confidence: 99%

“…The results revealed that complex of hydroxypropyl-β-cyclodextrin with lornoxicam enhanced the dissolution rate of lornoxicam in acidic medium. 37 Gidwani & Vyas 38 prepared sustained release matrix tablets of a poorly soluble anticancer drug altretamine by fusion method using cyclodextrin complexation approach. The prepared binary system of Altretaminehydroxypropyl-β-cyclodextrin was developed to improve the aqueous solubility of drug.…”

Section: Figure 1 Depicts the Guest-host Inclusion Complexes Formationmentioning

confidence: 99%

See 1 more Smart Citation

Cyclodextrin: A Promising Candidate in Enhancing Oral Bioavailability of poorly Water Soluble Drugs

Maheriya¹

2017

MOJBB

View full text Add to dashboard Cite

Most of the drugs administered through oral route have poor aqueous solubility and dissolution rate. Cyclodextrin and its derivates represent as pharmaceutical adjuvants to overcome this challenges and helps in development of stable formulation with enhanced bioavailability. Cyclodextrins are unique structure with versatile physicochemical properties which aids the pharmaceutical scientists to overcome drug delivery challenges for poorly aqueous soluble drugs. Cyclodextrin and its derivates are widely useful as solubilizers, assisting in preparation of various dosage forms such as liquid oral, solid, and parenteral preparations. Cyclodextrins interacts with appropriately sized guest molecules to form inclusion complex and enhance the aqueous solubility, physical chemical stability, and bioavailability of drugs. Through the various reported literatures, the review highlights the concept of cyclodextrin and its derivatives in enhancing solubility and bioavailability of poorly aqueous soluble drugs.

show abstract

Section: Figure 1 Depicts the Guest-host Inclusion Complexes Formationmentioning

confidence: 99%

Section: Figure 1 Depicts the Guest-host Inclusion Complexes Formationmentioning

confidence: 99%

Cyclodextrin: A Promising Candidate in Enhancing Oral Bioavailability of poorly Water Soluble Drugs

Maheriya¹

2017

MOJBB

View full text Add to dashboard Cite

show abstract

“…The characteristic peaks of lornoxicam were absent in niosomes. Blank niosomes were used to eliminate the interference of the other constituents of the niosomes (28). FT-IR study showed characteristic peaks of Lor as -NH stretching (3,090 cm ).…”

Section: Characterization Of Optimized Lor-nio Dispersionmentioning

confidence: 99%

Niosomal Gel of Lornoxicam for Topical Delivery: In vitro Assessment and Pharmacodynamic Activity

2013

View full text Add to dashboard Cite

Abstract. Lornoxicam is a potent oxicam class of non steroidal anti-inflammatory agent, prescribed for mild to moderate pain and inflammation. Niosomal gel of lornoxicam was developed for topical application. Lornoxicam niosomes (Lor-Nio) were fabricated by thin film hydration technique. Bilayer composition of niosomal vesicles was optimized. Lor-Nio dispersion was characterized by DSC, XRD, and FT-IR. Morphological evaluation was performed by scanning electron microscopy (SEM). Lor-Nio dispersion was incorporated into a gel using 2% w/w Carbopol 980 NF. Rheological and texture properties of LorNio gel formulation showed suitability of the gel for topical application. The developed formulation was evaluated for in vitro skin permeation and skin deposition studies, occlusivity test and skin irritation studies. Pharmacodynamic activity of the Lor-Nio gel was performed by carragenan-induced rat paw model. Optimized Lor-Nio comprised of Span 60 and cholesterol in a molar ratio of 3:1 with 30 μM dicetyl palmitate as a stabilizer. It had particle size of 1.125±0.212 μm (d 90 ), with entrapment efficiency of 52.38± 2.1%. DSC, XRD, and IR studies showed inclusion of Lor into niosomal vesicles. SEM studies showed spherical closed vesicular structure with particles in nanometer range. The in vitro skin permeation studies showed significant improvement in skin permeation and skin deposition for Lor-Nio gel (31.41±2.24 μg/ cm 2 , 30.079±1.2 μg/cm 2 ) over plain lornoxicam gel (7.37±1.27 μg/cm 2 , 6.6±2.52 μg/cm 2 ). The Lor-Nio gel formulation showed enhanced anti-inflammatory activity by exhibiting mean edema inhibition (87.69± 1.43%) which was significantly more than the plain lornoxicam gel (53.84±2.21%).

show abstract

“…It is reported that the increase in polymer molecular weight is usually coupled with an increase in the entanglement of the polymer macromolecules accompanied by a decrease in polymer dissolution rate. This collectively leads to decrease in water and drug diffusion coefficients and therefore decrease in drug release (33).…”

Section: In Vitro Drug Release Studiesmentioning

confidence: 99%

Biodegradable Ocular Inserts for Sustained Delivery of Brimonidine Tartarate: Preparation and In Vitro/In Vivo Evaluation

2011

Self Cite

View full text Add to dashboard Cite

The bioavailability of therapeutic agents from eye drops is usually limited due to corneal barrier functions and effective eye protective mechanisms. Therefore, the current study aims to enhance ocular bioavailability of brimonidine, a potent antiglaucoma drug, through the preparation of ocular inserts. Solvent casting technique was employed to prepare the inserts using polyvinylpyrrolidone K-90 (PVP K-90) as film-forming polymer blended with different viscosity grades of bioadhesive polymers namely hydroxypropyl methycellulose, carbopol, sodium alginate, and chitosan. The prepared ocular inserts were evaluated for various physicochemical parameters, swelling behavior, and in vitro release patterns. Sodium alginate-based ocular inserts revealed the most sustainment in drug release (99% at 6 h), so it was selected for further modifications via coating it, on one side or dual sides, using hydrophobic film composed of either ethylcellulose or Eudragit RSPO. The obtained in vitro release results for the modified ocular inserts revealed that ethylcellulose is superior to Eudragit RSPO in terms of brimonidine release sustainment effect. Ocular inserts composed of 7% PVP K-90, 1.5% low molecular weight sodium alginate with or without ethylcellulose coat were able to sustain the in vitro release of brimonidine. Their therapeutic efficacy regarding intraocular pressure (IOP) lowering effect when inserted in albino rabbits eyes showed superior sustainment effect compared with that of brimonidine solution. Furthermore, due to both the mucoadhesive property and the drug sustainment effect, the one-side-coated ocular insert showed more IOP lowering effect compared with that of its non-coated or dual-side-coated counterpart.

show abstract

Design and In Vitro Evaluation of Novel Sustained-Release Double-Layer Tablets of Lornoxicam: Utility of Cyclodextrin and Xanthan Gum Combination

Cited by 38 publications

References 38 publications

Cyclodextrin: A Promising Candidate in Enhancing Oral Bioavailability of poorly Water Soluble Drugs

Cyclodextrin: A Promising Candidate in Enhancing Oral Bioavailability of poorly Water Soluble Drugs

Niosomal Gel of Lornoxicam for Topical Delivery: In vitro Assessment and Pharmacodynamic Activity

Biodegradable Ocular Inserts for Sustained Delivery of Brimonidine Tartarate: Preparation and In Vitro/In Vivo Evaluation

Contact Info

Product

Resources

About