Cyclodextrin: A Promising Candidate in Enhancing Oral Bioavailability of poorly Water Soluble Drugs

Maheriya, Pankaj M.

doi:10.15406/mojbb.2017.03.00034

Cited by 24 publications

(21 citation statements)

References 37 publications

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“…Through the various reported studies, cyclodextrin complexes highlighted the concept of cyclodextrin and its derivatives in enhancing solubility and bioavailability of BCS Class-II drugs. [87,139] Cyclodextrin in nasal drug delivery Nasal drug delivery offers a better approach for systemic administration of drugs by avoiding first-pass metabolism or degradation in liver and gastrointestinal tract. Cyclodextrin complexes improve the absorption of drugs through nasal mucosa and increase their solubility and nasal absorption.…”

Section: Cyclodextrins and Nanotechnologymentioning

confidence: 99%

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Budhwar¹

2018

AJP

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Inclusion complexes have various applications in different fields of drug delivery and pharmaceutical industry due to their ability of complexation with guest molecules and enhancement of the physicochemical properties of guest molecules. Cyclodextrins and their derivatives have the ability to encapsulate the bioactive compounds into its cavity and protect these from the environmental conditions, improve the solubility, bioavailability, and other properties also. The aim of this review is to highlight the advantages of cyclodextrins in the enhancement of physicochemical properties of drugs (such as solubility, stability, bioavailability, permeability, and others), different methods for production and various characterization techniques used for evaluation of complexes. Applications of cyclodextrin complexes in pharmaceutical and other fields are also explained here with examples. Thus cyclodextrins, because of their continuing ability to find several novel applications in drug delivery, are expected to solve many problems accompanied with the delivery of different novel drugs through various delivery routes.

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Section: Cyclodextrins and Nanotechnologymentioning

confidence: 99%

“…The cyclodextrin aggregates present the ability to form complexes, and nanosized aggregates, and nanotube-type host/guest architectures can be envisaged. [24,139,159] …”

Section: Cyclodextrins and Their Tendency To Form Aggregatesmentioning

confidence: 99%

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Budhwar¹

2018

AJP

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“…Cyclodextrins are extensively used as adjuvants to make drugs more soluble, stable and bioavailable 1,2 . They are biocompatible, water-soluble, stable macro-molecules and are extensively used for drug delivery both as nano-carriers and solubilizer 3–5 .…”

Section: Introductionmentioning

confidence: 99%

Methyl-β-cyclodextrin, an actin depolymerizer augments the antiproliferative potential of microtubule-targeting agents

Mundhara

Majumder

Panda

2019

Sci Rep

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Methyl-β-cyclodextrin (MCD), an established pharmacological excipient, depolymerizes the actin cytoskeleton. In this work, we investigated the effect of MCD-mediated actin depolymerization on various cellular phenotypes including traction force, cell stiffness, focal adhesions, and intracellular drug accumulation. In addition to a reduction in the contractile cellular traction, MCD acutely inhibits the maturation of focal adhesions. Alteration of contractile forces and focal adhesions affects the trypsin-mediated detachment kinetics of cells. Moreover, MCD-mediated actin depolymerization increases the intracellular accumulation of microtubule-targeting agents (MTAs) by ~50% with respect to the untreated cells. As MCD treatment enhances the intracellular concentration of drugs, we hypothesized that the MCD-sensitized cancer cells could be effectively killed by low doses of MTAs. Our results in cervical, breast, hepatocellular, prostate cancer and multidrug-resistant breast cancer cells confirmed the above hypothesis. Further, the combined use of MCD and MTAs synergistically inhibits the proliferation of tumor cells. These results indicate the potential use of MCD in combination with MTAs for cancer chemotherapy and suggest that targeting both actin and microtubules simultaneously may be useful for cancer therapy. Importantly, the results provide significant insight into the crosstalk between actin and microtubules in regulating the traction force and dynamics of cell deadhesion.

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“…Among various strategies to improve the water solubility and/or drug delivery of PSs [ 25 ], e.g., by using hydrophilic substituents (cationic or anionic groups [ 41 , 42 , 43 ], amino acids [ 44 , 45 ], peptides [ 46 , 47 ], sugars [ 48 , 49 , 50 ], polyethylene glycol derivatives [ 51 ], liposomes [ 52 , 53 ], or organic and inorganic nanoparticles [ 54 , 55 , 56 , 57 , 58 , 59 , 60 ], cyclodextrins (CDs) represent interesting hydrophilic substituents to resolve these challenges and help in the development of drugs with enhanced water solubility [ 61 ] as well as enhanced drug delivery [ 62 , 63 , 64 , 65 ].…”

Section: Introductionmentioning

confidence: 99%

Use of Cyclodextrins in Anticancer Photodynamic Therapy Treatment

et al. 2018

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Photodynamic therapy (PDT) is mainly used to destroy cancerous cells; it combines the action of three components: a photoactivatable molecule or photosensitizer (PS), the light of an appropriate wavelength, and naturally occurring molecular oxygen. After light excitation of the PS, the excited PS then reacts with molecular oxygen to produce reactive oxygen species (ROS), leading to cellular damage. One of the drawbacks of PSs is their lack of solubility in water and body tissue fluids, thereby causing low bioavailability, drug-delivery efficiency, therapeutic efficacy, and ROS production. To improve the water-solubility and/or drug delivery of PSs, using cyclodextrins (CDs) is an interesting strategy. This review describes the in vitro or/and in vivo use of natural and derived CDs to improve antitumoral PDT efficiency in aqueous media. To achieve these goals, three types of binding modes of PSs with CDs are developed: non-covalent CD–PS inclusion complexes, covalent CD–PS conjugates, and CD–PS nanoassemblies. This review is divided into three parts: (1) non-covalent CD-PS inclusion complexes, covalent CD–PS conjugates, and CD–PS nanoassemblies, (2) incorporating CD–PS systems into hybrid nanoparticles (NPs) using up-converting or other types of NPs, and (3) CDs with fullerenes as PSs.

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Cyclodextrin: A Promising Candidate in Enhancing Oral Bioavailability of poorly Water Soluble Drugs

Cited by 24 publications

References 37 publications

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Methyl-β-cyclodextrin, an actin depolymerizer augments the antiproliferative potential of microtubule-targeting agents

Use of Cyclodextrins in Anticancer Photodynamic Therapy Treatment

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