Abstract:Background Prior to 2003, there was limited capacity for an HIV/AIDS response in China. In early 2003, China launched a 5-year China Comprehensive AIDS Response Programme (China CARES) to contain the spread of HIV infection and reduce its impact. This article describes the China CARES’ practices and experiences.Methods China CARES covered 83.3 million people in 127 programme sites chosen from 28 provinces based on HIV prevalence. Each China CARES site was required to carry out surveillance and surveys to under… Show more
“…In response to the HIV/AIDS epidemic, China has made major strides in access to treatment, implementing the National Free Antiretroviral Therapy (ART) program which covers 28 provinces across China[3,4]. As accessibility to ART improves and life expectancy of HIV-infected individuals increases, new challenges, many of which are more typical of an aging population, have emerged[5,6] including in low- and middle-income countries (LMIC) where the burden of chronic disease is growing[7].…”
Background-Cerebrovascular risk is increased in people living with HIV infection compared with age-matched uninfected individuals. Cerebrovascular endothelial dysfunction related to antiretroviral therapy and inflammation may contribute to higher stroke risk in HIV infection.
“…In response to the HIV/AIDS epidemic, China has made major strides in access to treatment, implementing the National Free Antiretroviral Therapy (ART) program which covers 28 provinces across China[3,4]. As accessibility to ART improves and life expectancy of HIV-infected individuals increases, new challenges, many of which are more typical of an aging population, have emerged[5,6] including in low- and middle-income countries (LMIC) where the burden of chronic disease is growing[7].…”
Background-Cerebrovascular risk is increased in people living with HIV infection compared with age-matched uninfected individuals. Cerebrovascular endothelial dysfunction related to antiretroviral therapy and inflammation may contribute to higher stroke risk in HIV infection.
“…Additionally, our findings demonstrate that funding has not been proportional to the burden of HIV infection in several important at-risk groups, with notable underspending among MSM, partners of people living with HIV, and prisoners and other confined populations. Resource allocation to both HIV treatment and prevention in these at risk populations must be strengthened and may ultimately help to reduce overall costs [17,18]. …”
ObjectiveWe assessed HIV/AIDS expenditures in Dehong Prefecture, Yunnan Province, one of the highest prevalence regions in China, and describe funding sources and spending for different categories of HIV-related interventions and at-risk populations.Methods2010 HIV/AIDS expenditures in Dehong Prefecture were evaluated based on UNAIDS’ National AIDS Spending Assessment methodology.ResultsNearly 93% of total expenditures for HIV/AIDS was contributed by public sources. Of total expenditures, 52.7% was allocated to treatment and care, 24.5% to program management and administration and 19.8% to prevention. Spending on treatment and care was primarily allocated to the treatment of opportunistic infections. Most (40.4%) prevention spending was concentrated on most-at-risk populations, injection drug users (IDUs), sex workers, and men who have sex with men (MSM), with 5.5% allocated to voluntary counseling and testing. Prevention funding allocated for MSM, partners of people living with HIV and prisoners and other confined populations was low compared to the disproportionate burden of HIV/AIDS in these populations. Overall, people living with HIV accounted for 57.57% of total expenditures, while most-at-risk populations accounted for only 7.99%.ConclusionsOur study demonstrated the applicability of NASA for tracking and assessing HIV expenditure in the context of China, it proved to be a useful tool in understanding national HIV/AIDS response from financial aspect, and to assess the extent to which HIV expenditure matches epidemic patterns. Limited funding for primary prevention and prevention for MSM, prisoners and partners of people living with HIV, signal that resource allocation to these key areas must be strengthened. Comprehensive analyses of regional and national funding strategies are needed to inform more equitable, effective and cost-effective HIV/AIDS resource allocation.
“…The NFATP database has been described in previous publications. 18–20 Standardized case report forms (CRFs) are used by China CDC public health workers to gather information from local ART clinic staff on patients meeting criteria for inclusion in the NFATP database. Different CRFs are used to track five treatment statuses of a patient’s treatment: an initial patient assessment, treatment follow-up, treatment regimen change, treatment/follow-up termination, and transfer of care.…”
The chief concerns for antiretroviral therapy (ART) programs considering removal of CD4+ cell count thresholds for treatment are the increased incidence of ART-related adverse events. A nationwide observational cohort study was conducted among patients who initiated ART in 2012. We divided the eligible patients into three groups: an early ART group with a baseline CD4+ cell count of 500 cells/μL or greater, a standard ART group with a baseline CD4+ cell count between 350 and 499 cells/μL, and a late ART group with a baseline CD4+ cell count between 200 and 349 cells/μL. These patients were followed up to December 31, 2014 and observed for three outcomes: virological failure, treatment nonretention, or time to death. Patients who met the eligibility criteria numbered at 26,752. Out of all study participants, 20,827 participants were in late ART group, 4336 were in standard ART group, and 1589 were in early ART group. Patients in late ART group were more likely to become virally suppressed 12 and 24 months after treatment initiation than patients in early ART group [adjusted odds ratio (aOR) 0.81; 95% CI, 0.69–0.95 and aOR, 0.78; 95% CI, 0.65–0.94]. Treatment nonretention was also less likely to occur among patients in late ART group than early ART group 12 months after treatment initiation (aOR, 0.85; 95% CI, 0.75–0.96). Compared with early ART group, neither standard ART group nor late ART group had a statistically significant difference in the time-to-death analysis. Late ART initiates were more likely to be virally suppressed and retained on treatment than early ART initiates. The importance of treatment retention and adherence should be emphasized for high CD4+ patients newly initiated to ART therapy through education and counseling programs.
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