Relationship Between HIV Infection, Antiretroviral Therapy, Inflammatory Markers, and Cerebrovascular Endothelial Function Among Adults in Urban China

Chow, Felicia C.; Li, Yanling; Hu, Ying-Huan; Chan, Joy; Wang, Huanling; Xu, Wei-Hai; Price, Richard W.; Sorond, Farzaneh A.; Li, Taisheng

doi:10.1097/qai.0000000000001254

Cited by 19 publications

(21 citation statements)

References 39 publications

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“…Human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) is associated with opportunistic pathologies due to low activity of the immune system ( Raso et al, 2007 ). Highly active antiretroviral therapy (HAART) is widely recommended for patients with HIV/AIDS as a way to prevent the onset of these pathologies ( Chow et al, 2017 ; Mendicino et al, 2016 ). However, HAART increases the cardiovascular risk of the patients ( Hsue et al, 2009 ; Lipshultz et al, 2003 ; Zareba et al, 2005 ), especially women ( Muyanja et al, 2016 ).…”

Section: Introductionmentioning

confidence: 99%

Blood pressure responses after resistance exercise session in women living with human immunodeficiency virus/acquired immunodeficiency syndrome

et al. 2018

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The aim of this study was to verify blood pressure (BP) responses after a single resistance exercise session in women with human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS). Twelve patients underwent a resisted exercise session. BP, heart rate, and rate pressure product were evaluated before and during 120 min after the session. Mean cardiovascular values before and after the session were similar (P>0.05). Analysis of the individual data revealed that for 120 min after exercise, 5 and 4 patients presented a reduction in systolic and diastolic BP of ≥4 mmHg, respectively. The clinical characteristics of the patients appear to influence BP responses after exercise. Individual data showed that some of the HIV+ women demonstrated a clinically significant decrease in BP. Although a single resistance exercise session does not decrease BP in women with HIV/AIDS, individual data present heterogeneity and individual characteristics seem to influence BP reduction after a single session of resistance exercises.

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Section: Introductionmentioning

confidence: 99%

Blood pressure responses after resistance exercise session in women living with human immunodeficiency virus/acquired immunodeficiency syndrome

et al. 2018

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“…50 However, another study did not find an association between endothelial dysfunction, as shown by lower cerebral vasoreactivity on transcranial ultrasound, and inflammatory markers. 48 Exploratory analysis in the latter study did find an association between higher interleukin 6 and worse cerebral vasoreactivity in HIV-positive women, but not in HIV-infected men. These findings underlie the importance of expanding our cohort studies and evaluating potential underlying mechanisms independently in different populations.…”

Section: Cerebrovascular Diseasementioning

confidence: 69%

“…47 Another recent study in an HIV-positive cohort in China found an association between lopinavir/ritonavir and reduced cerebral vasoreactivity by Doppler, suggesting PI use may negatively impact vascular endothelial function. 48 Therefore, PIs likely should be avoided in patients at high risk for cerebrovascular disease.…”

Section: Cerebrovascular Diseasementioning

confidence: 99%

“…36 Studies have also found associations between vascular events and other clinical markers, such as low concurrent CD4 count and detectable blood HIV viral loads. 39,48,49 Pathophysiologic mechanisms behind these results suggest that ongoing inflammation likely plays an important role, but data remain mixed. Inflammatory markers have been found to be associated with increased risk of vascular events.…”

Section: Cerebrovascular Diseasementioning

confidence: 99%

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Global Health Neurology: HIV/AIDS

Patel

Spudich

2018

Semin Neurol

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With the advent of combination antiretroviral therapies, the mortality rate from HIV has declined, while the prevalence of long-term HIV-related neurologic complications continues to rise. Thirty-six million individuals are living with HIV around the world, many of whom reside in resource-limited settings. The majority of studies have focused on individuals residing in the developed world, while the impact of HIV disproportionately affects people living in developing countries. This review focuses on recent domestic and international studies regarding neurologic complications related to HIV, including opportunistic infections, peripheral neuropathy, cerebrovascular disease, and HIV-associated neurocognitive disorders, in light of the growing population affected by these conditions.

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“…Vasculitis secondary to infection tends to have a poor prognosis. The most common manifestation of such vasculitis is ischemic infarct, with intracranial hemorrhage (14). Left-sided IE-related CNS complications can be subclinical, asymptomatic events in up to 60-80% of cases (1).…”

Section: Infectious Vasculitis or Arteritismentioning

confidence: 99%

Imaging of cerebrovascular complications of infection

Shen¹,

Shen²,

Pu³

et al. 2018

Quant. Imaging Med. Surg

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Cerebrovascular complications may occur in infectious diseases in the setting of infective endocarditis, central nervous system (CNS) infections, systemic bacteremia and sepsis. Cerebrovascular complications of infections include vasculitis, mycotic aneurysms, and thrombophlebitis. Infectious vasculitis of the CNS may cause cerebral hemorrhage, infarction or ischemia. Ruptured aneurysms may endanger the patient's life. Infectious thrombophlebitis may cause intracranial pressure to increase and lead to cerebral hemorrhage. These cerebrovascular complications are associated with a poor prognosis and often cause irreversible neurological deficits. Cerebrovascular events secondary to infection are not easily distinguishable from the more common cerebral infarct and non-infectious vasculitis. In addition, the clinical manifestations of cerebrovascular complications of infections are non-specific and highly variable. Therefore, early imaging, antibiotics, and anticoagulation may be lifesaving the patient's life and prevent disability. The main focus of this article is to review imaging analysis of the cerebrovascular complications of infections and imaging features that help differentiate them from non-infectious vascular diseases.

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Relationship Between HIV Infection, Antiretroviral Therapy, Inflammatory Markers, and Cerebrovascular Endothelial Function Among Adults in Urban China

Abstract: Background-Cerebrovascular risk is increased in people living with HIV infection compared with age-matched uninfected individuals. Cerebrovascular endothelial dysfunction related to antiretroviral therapy and inflammation may contribute to higher stroke risk in HIV infection.

Cited by 19 publications

References 39 publications

Blood pressure responses after resistance exercise session in women living with human immunodeficiency virus/acquired immunodeficiency syndrome

Blood pressure responses after resistance exercise session in women living with human immunodeficiency virus/acquired immunodeficiency syndrome

Global Health Neurology: HIV/AIDS

Imaging of cerebrovascular complications of infection

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