Design and evaluation of a Monte Carlo based model of an orthovoltage treatment system

Penchev, Petar; Mäder, Ulf; Fiebich, Martin; Zink, Klemens

doi:10.1016/j.zemedi.2015.05.005

Cited by 5 publications

(7 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Several groups have validated their models using PDDs and beam profiles with reported agreement within 6% for PDDs and 10% for beam profiles at depth. 14 , 15 , 16 , 31 , 32 , 33 In this work, the PDDs agreed to within 2% for all points across all simulated beams demonstrating a good match of beam quality. This agreement could be attributed to a good match of the source electron beam and photon beam filtration.…”

Section: Discussionsupporting

confidence: 68%

“…With no commercial TPS available for kV radiotherapy, in‐house solutions have to be developed. In contrast to previous publications, using C++ and MATLAB codes, Python was used to develop the TPI in this work extending the functionality of previous publications 16 , 19 and opening up the possibility of sharing the code with other users. The ability to overwrite structure HU values can be used to introduce gold and lead internal shields as well as lead cutouts which are commonly used clinically to conform the beam to the exact tumor shape and spare organs at risk.…”

Section: Discussionmentioning

confidence: 99%

“… 13 Several studies have created MC models of kV radiotherapy units. 9 , 14 , 15 , 16 , 17 , 18 , 19 Knoos et al. 14 modeled 120 and 200 kV beams of the D3225 unit (Gulmay Medical Ltd, UK) and simulated two sample dose distributions on patient CT images.…”

Section: Introductionmentioning

confidence: 99%

“…Chow et al 19 used MATLAB (The MathWorks Inc.) to create a TPS for small animal irradiations limited to a single energy of 225 kVp. Penchev et al 16 modeled WOmed T-200 kV unit (WOLF-Medizintechnik GmbH, Germany) and developed a graphical user interface to set up simulations for a range of dosimetric problems using phantoms and CT images. Their framework allowed modification of the applicator geometry but did not allow further beam modification, for example, using lead cutouts or shielding.…”

Section: Introductionmentioning

confidence: 99%

“…However, MC calculations have been extensively used in kV energy range research 13 . Several studies have created MC models of kV radiotherapy units 9,14–19 . Knoos et al 14 .…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Clinical treatment planning for kilovoltage radiotherapy using EGSnrc and Python

Nikandrovs

McClean

Shields

et al. 2022

J Applied Clin Med Phys

View full text Add to dashboard Cite

Kilovoltage radiotherapy dose calculations are generally performed with manual point dose calculations based on water dosimetry. Tissue heterogeneities, irregular surfaces, and introduction of lead cutouts for treatment are either not taken into account or crudely approximated in manual calculations. Full Monte Carlo (MC) simulations can account for these limitations but require a validated treatment unit model, accurately segmented patient tissues and a treatment planning interface (TPI) to facilitate the simulation setup and result analysis. EGSnrc was used in this work to create a model of Xstrahl kilovoltage unit extending the range of energies, applicators, and validation parameters previously published. The novel functionality of the Python‐based framework developed in this work allowed beam modification using custom lead cutouts and shields, commonly present in kilovoltage treatments, as well as absolute dose normalization using the output of the unit. 3D user‐friendly planning interface of the developed framework facilitated non‐co‐planar beam setups for CT phantom MC simulations in DOSXYZnrc. The MC models of 49 clinical beams showed good agreement with measured and reference data, to within 2% for percentage depth dose curves, 4% for beam profiles at various depths, 2% for backscatter factors, 0.5 mm of absorber material for half‐value layers, and 3% for output factors. End‐to‐end testing of the framework using custom lead cutouts resulted in good agreement to within 3% of absolute dose distribution between simulations and EBT3 GafChromic film measurements. Gamma analysis demonstrated poor agreement at the field edges which was attributed to the limitations of simulating smooth cutout shapes. Dose simulated in a heterogeneous phantom agreed to within 7% with measured values converted using the ratio of mass energy absorption coefficients of appropriate tissues and air.

show abstract

Section: Discussionsupporting

confidence: 68%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…However, MC calculations have been extensively used in kV energy range research 13 . Several studies have created MC models of kV radiotherapy units 9,14–19 . Knoos et al 14 .…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Clinical treatment planning for kilovoltage radiotherapy using EGSnrc and Python

Nikandrovs

McClean

Shields

et al. 2022

J Applied Clin Med Phys

View full text Add to dashboard Cite

show abstract

Estimation of the relative biological effectiveness for double strand break induction of clinical kilovoltage beams using Monte Carlo simulations

McElligott,

Nikandrovs,

McCavana

et al. 2024

Medical Physics

View full text Add to dashboard Cite

BackgroundThe Relative Biological Effectiveness (RBE) of kilovoltage photon beams has been previously investigated in vitro and in silico using analytical methods. The estimated values range from 1.03 to 1.82 depending on the methodology and beam energies examined.PurposeThe focus of this work was to independently estimate RBE values for a range of clinically used kilovoltage beams (70–200 kVp) while investigating the suitability of using TOPAS‐nBio for this task.MethodsPreviously validated spectra of clinical beams were used to generate secondary electron spectra at several depths in a water tank phantom via TOPAS Monte Carlo (MC) simulations. Cell geometry was irradiated with the secondary electrons in TOPAS‐nBio MC simulations. The deposited dose and the calculated number of DNA strand breaks were used to estimate RBE values.ResultsMonoenergetic secondary electron simulations revealed the highest direct and indirect double strand break yield at approximately 20 keV. The average RBE value for the kilovoltage beams was calculated to be 1.14.ConclusionsTOPAS‐nBio was successfully used to estimate the RBE values for a range of clinical radiotherapy beams. The calculated value was in agreement with previous estimates, providing confidence in its clinical use in the future.

show abstract

A Monte Carlo study on dose distribution of an orthovoltage radiation therapy system

et al. 2023

View full text Add to dashboard Cite

Design and evaluation of a Monte Carlo based model of an orthovoltage treatment system

Cited by 5 publications

References 23 publications

Clinical treatment planning for kilovoltage radiotherapy using EGSnrc and Python

Clinical treatment planning for kilovoltage radiotherapy using EGSnrc and Python

Estimation of the relative biological effectiveness for double strand break induction of clinical kilovoltage beams using Monte Carlo simulations

A Monte Carlo study on dose distribution of an orthovoltage radiation therapy system

Contact Info

Product

Resources

About