Design and development of paliperidone mesoporous silica template as a platform for surge dose drug delivery system

Pande, Vishal; Jadhav, Komal Sadashiv; Giri, Mahendra; Kendre, Prakash N.; Vibhute, Somanth Kedarling; Borawake, Dhanashri Devendra

doi:10.1080/10667857.2018.1538186

Cited by 12 publications

(12 citation statements)

References 16 publications

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“…The in-vitro drug release in 120 min for MSN loaded drug was 96% while that of the plain drug was 30%. The in-vivo study also confirmed the enhancement of solubility and dissolution of Palperidone [30].…”

Section: Targeted and Controlled Drug Deliverysupporting

confidence: 67%

“…The solubility of the drugs markedly increase due to the confinement of the drugs into the tiny pores of MSNs having a size of 3-50 nm range [28]. The entrapment of the drug in MSNs is done by the solvent impregnation method [16,29,30]. Not only the drug solubility increases due to entrapment but also the drug can be protected from different destructive environments [31].…”

Section: Targeted and Controlled Drug Deliverymentioning

confidence: 99%

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State of the Art Review on Emerging Applications of Mesoporous Silica

Pote¹,

Pande²,

Patel³

et al. 2020

TONMJ

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The recent advances in the drug delivery system using a variety of technological platforms have resulted in innovation in the attitude towards diagnosis and therapeutics alike in the present times. Mesoporous Silica possesses favourable chemical properties, thermal stability, and biocompatibility. The unique structure of mesoporous silica makes possible the effective loading of drugs and their subsequent release in a controlled manner at the target site. The properties like pore size, high drug loading, and porosity as well as the surface properties of Mesoporous silica make them a suitable platform for many drug delivery applications. This review focuses on the applications and the advances made in the mesoporous silica to broaden the spectrum of its use especially in the field of medicine. The Mesoporous Silica carrier has proved its use in the field of biosensing, controlled and targeted drug release, gene delivery, water treatment, solubility and bioavailability enhancement and wound healing.

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Section: Targeted and Controlled Drug Deliverysupporting

confidence: 67%

Section: Targeted and Controlled Drug Deliverymentioning

confidence: 99%

State of the Art Review on Emerging Applications of Mesoporous Silica

Pote¹,

Pande²,

Patel³

et al. 2020

TONMJ

Self Cite

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show abstract

“…Impregnation or incipient wetness impregnation method exploits the evaporation of the loading solvent to collect loaded drug particles rather than removing drug loaded particles from the loading solvent by other means. Upon the solvent evaporation, the aqueous solution containing drug can be allured into the porous or mesoporous channels on the silica surface through diffusion or by capillary movement . The use of this method to deposit therapeutic agents onto various sorts of silica templates has been reported .…”

Section: Strategies Of Loading Drugs Into Hollow Capsulesmentioning

confidence: 99%

“…Upon the solvent evaporation, the aqueous solution containing drug can be allured into the porous or mesoporous channels on the silica surface through diffusion or by capillary movement. [88,89] The use of this method to deposit therapeutic agents onto various sorts of silica templates has been reported. [89][90][91] However, the use of impregnation or incipient wetness impregnation still has a major drawback.…”

Section: Mesoporous Silica-mediated Drug Loadingmentioning

confidence: 99%

“…[88,89] The use of this method to deposit therapeutic agents onto various sorts of silica templates has been reported. [89][90][91] However, the use of impregnation or incipient wetness impregnation still has a major drawback. The remaining of loading solvent on silica templates can cause detrimental effects in vivo.…”

Section: Mesoporous Silica-mediated Drug Loadingmentioning

confidence: 99%

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Current Advances of Hollow Capsules as Controlled Drug Delivery Systems

Tran

Bhave

2020

ChemistrySelect

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Polymeric hollow capsules have attracted increasing interest for the development of controlled drug delivery systems due to their capacities to load high amount of drugs and be able to finely tune the drug release profile. Various methods and strategies for capsule preparation and drug loading have been developed over time. Besides that, the controlled drug release from hollow capsules upon external and internal triggers is of great interest and has been a research focus in this area. This article aims to give the most recent progress review on hollow capsule based controlled drug delivery systems with a highlight on strategies being used for drug loading and stimuli-release. In detail, the fabrication of hollow capsules using templateassisted or template-free methods will be introduced first. This will be followed by current strategies for pre-loading and postloading of therapeutic agents into capsules. The article will then be particularly focused on discussing diverse drug-release systems corresponding to various stimuli conditions including temperature, pH, ultrasound, light irradiation and enzyme degradation.

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Peptide‐Enabled Thrombus‐Targeting Nanoparticles for Highly Effective Targeted CT Imaging and Eradication of Thrombi

Bao

Miao

et al. 2023

Adv Funct Materials

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Thrombotic disease poses a significant threat to human health as it blocks blood vessels and leads to severe symptoms. Effective treatment requires targeted therapy and precise localization of the thrombus, but traditional drugs are limited in their targeting ability and ability to locate the thrombus. To overcome these issues, a nanoparticle capable of both thrombus targeting and computed tomography (CT) imaging is developed. Phage display technology is used to screen for the thrombus‐targeting peptide termed GK, which is then linked to the surface of macroporous silica (Mp‐SiO2) with a Bi core to create Mp‐Bi@SiO2‐GK. The large pores of Mp‐Bi@SiO2‐GK enable the transport of the drug Urokinase (UK), while the Bi core provides the capabilities of CT imaging and photothermal therapy. The Mp‐Bi@SiO2‐GK nanoparticles precisely target thrombi in mouse carotid arteries and locate them via CT imaging. Furthermore, the combination of Bi‐enabled photothermal therapy and UK‐induced chemotherapy enhance the thrombolysis efficiency. Treatment with Mp‐Bi@SiO2‐GK nanoparticles do not harm tissues/organs or affect liver/kidney metabolism. These results show that Mp‐Bi@SiO2‐GK exhibits precise thrombus targeting and efficient imaging/treatment capability, making it a promising tool for the diagnosis and treatment of thrombosis.

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Design and development of paliperidone mesoporous silica template as a platform for surge dose drug delivery system

Cited by 12 publications

References 16 publications

State of the Art Review on Emerging Applications of Mesoporous Silica

State of the Art Review on Emerging Applications of Mesoporous Silica

Current Advances of Hollow Capsules as Controlled Drug Delivery Systems

Peptide‐Enabled Thrombus‐Targeting Nanoparticles for Highly Effective Targeted CT Imaging and Eradication of Thrombi

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