Design and development of metallic biomaterials with biological and mechanical biocompatibility

Abstract

In the present article, the recent trends in the research and development of metallic biomaterials are discussed with focus on the results obtained by the author's group. The design of biocompatible metallic biomaterials possessing excellent biological and mechanical properties, including titanium alloys with low Young's modulus, is reviewed with focus on Young's modulus, fatigue strength, and peculiar behavior. The evaluation of biological compatibility including cell viability and living tissue compatibility using animal models and surface modifications using bioactive ceramic and blood‐compatible polymers are summarized. © 2019 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 107A: 944–954, 2019.

Using Artificial Skin Devices as Skin Replacements: Insights into Superficial Treatment

“…The mechanical properties of artificial skin device substrates should thus match skin‐like parameters so as to provide adequate protection. This also fulfills the criteria of mechanical biocompatibility, allowing better integration between device and body . Biological agents also present a threat in the form of infections and the skin is able to prevent this through biochemical defenses.…”

“…This also fulfills the criteria of mechanical biocompatibility, allowing better integration between device and body. [41,42] Biological agents also present a threat in the form of infections and the skin is able to prevent this through biochemical defenses. This becomes even more important with implants as wet, implanted devices can be prone to biofouling and corrosion.…”

Comparative Study on the Corrosion Behavior of Ti Metal, Ti-6al-4v and Co-Cr-W Alloys in Artificial Saliva

“…To examine the effect of pH of the artificial saliva on corrosion behavior of the three tested materials, EIS measurements were carried out at the open circuit potential after 1 h immersion in the test solution of different pH values (2)(3)(4)(5)(6)(7)(8)(9)(10)(11). The impedance results of the three materials: CoCrW, Ti and TAV are expressed in the form of Nyquist plots as shown in Fig.6ac.…”

“…Titanium and titanium alloys have been used in medical and dental applications in consequence of their low density, high specific strength, appropriate mechanical properties, low elastic modulus, good biocompatibility and super corrosion resistance in body fluids [1,2]. The corrosion resistance of Ti and its alloys is due to the formation of an insoluble titanium oxide layer [3].…”

Novel α + β Type Ti-Fe-Cu Alloys Containing Sn with Pertinent Mechanical Properties

“…These alloys have found their way in various application fields, such as the aeronautic industry, transport engineering, chemical engineering, and medicine, owing to those light weight; high strength, which extends to a wide temperature scale; and its biocompatibility and non-corrosive nature [1][2][3]. Thus, due to these superior characteristics over other materials, titanium and its alloys have found a special attention in the biomedical field [4][5][6][7][8][9][10][11][12][13][14]. However, to be an ideal candidate as a replacement material in the case of implants in the human body, along with being biocompatible, it should be able to imitate the native part as closely as possible.…”