Design and development of insulin microneedles for diabetes treatment

Zong, Qida; Guo, Ranran; Dong, Naijun; Ling, Guixia; Zhang, Peng

doi:10.1007/s13346-021-00981-y

Cited by 23 publications

(12 citation statements)

References 59 publications

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“…With a low accelerating voltage, SEM (Hitachi SU 8030, Japan) was used to examine the morphology of microneedle patches to determine the size, shape, and other physical characteristics of the needles (1.0kV) [24,25]. To prevent electrical charges on the cross microneedles, a modest accelerating voltage was applied [17][18][19]. Digital photographs of coated cross-microneedles were taken at various magnifications from a fixed working distance (11.6 mm) (30, 80, 110 or 120 x).…”

Section: Scanning Electron Microscopy (Sem)mentioning

confidence: 99%

“…Using a Vernier calliper, prepared microneedle patches and transdermal patches were evaluated for thickness uniformity [17,18]. Individually weighing patches that were chosen at random allowed for the study of weight variance, and micrometer measurements of film thickness were made at random locations on all batches of the film [26].…”

Section: Thickness and Weight Variation Folding Of Formulated Transde...mentioning

confidence: 99%

“…In a nearby abattoir, porcine ears were collected from recently slaughtered pigs. Full-thickness, non-dermatomed skin was chosen, and the outer layer that was intended to be used for the experiment was separated using a skin grafting handle after being washed with ice-cold, deionized water [18,19]. A slice of skin with a uniform thickness of 1 mm was put on the Franz diffusion cell as depicted in fig.…”

Section: Skin Permeation Studies For ɣ-Oryzanolmentioning

confidence: 99%

“…Oliver, also known as Ɣ-Oryzanol, is derived from rice bran and rice bran oil, with the former containing a higher percentage of oliver (20-30%) than the latter [14][15][16]. Alpha-tocopherol, ascorbyl palmitate, and Ɣ-Oryzanol are used as antioxidants in quantities ranging from 0.2-2.5% [17][18][19]. Furthermore, Ɣ-Oryzanol blocks UVA and UVB radiation.…”

Section: Introductionmentioning

confidence: 99%

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Evaluating the Impact of Solid Microneedles on the Transdermal Drug Delivery System for Ɣ-Oryzanol

Kaur

Thakur

Goswami³

2022

Int J App Pharm

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Objective: This study's goals were to develop a minimally invasive array of biocompatible polymeric solid microneedles and formulate a transdermal patch of drug Ɣ-Oryzanol as per poke and patch technology. Methods: Scanning electron microscopy was used to analyse the morphology of the solid microneedle arrays, which were created using a stereolithography (SLA) printer with high-resolution capabilities (25 and 140 microns for the z and x axes, respectively). Transdermal Patches of Ɣ-Oryzanol were formulated and evaluated for various characterization parameters. Further, the produced microneedle-transdermal drug delivery system of Ɣ-Oryzanol was examined for microneedle insertion skin and permeation of the drug across the porcine skin. Results: Solid microneedle arrays were manufactured using biocompatible Class I Dental SG resin having dimensions of 600 µm height and 300 µm width with tip diameters of 30 µm and 1.85 mm interspacing (Distance from tip to tip) and they were strong enough to penetrate porcine skin to a depth of 381.356 µm crossing the stratum corneum layer without causing any structural changes. Transdermal patches containing Ɣ-Oryzanol were formulated using different ratios of HPMC: Eudragit E-100. Good, consistent, and transparent films were formulated when the thickness of the film ranges between 0.516±0.25-0.628±0.21 mm, average weights ranged from 168.23±2.61to171.22±1.25(10/cm2), folding endurance ranged in between 10 folds to 12 folds for all the formulations with tensile strength lie between the 0.365 kg/mm2 to 0.465 kg/mm2. All the formulations showed good drug content between 99.3±0.06%-90.4±1.64% with 100% flat surfaces. Moisture content was found in the range of 2.012±0.013 to 4.213±0.031. Drug permeation studies reveal that compound Ɣ-Oryzanol transdermal patches didn’t show significant permeation across porcine skin (4.802.25 g/cm2) without piercing with microneedles while after poking skin using microneedles (74.502.35 g/cm2) drug showed good penetration properties. It was found that the amount of drug delivered increased to 44.251.57 g/cm2 at 2 min, which was 14.502.35 g/cm2 at 1 min to 4 min 74.502.35 g/cm2. Conclusion: Successful preparation of the Microneedle-Transdermal drug delivery system of Ɣ-Oryzanol and their evaluation indicated that the quality and consistency of the formulated preparation were excellent. With advantages in terms of lowered dose frequency, better patient compliance, and bioavailability, this may find use in the therapeutic field.

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Section: Scanning Electron Microscopy (Sem)mentioning

confidence: 99%

Section: Thickness and Weight Variation Folding Of Formulated Transde...mentioning

confidence: 99%

Section: Skin Permeation Studies For ɣ-Oryzanolmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Evaluating the Impact of Solid Microneedles on the Transdermal Drug Delivery System for Ɣ-Oryzanol

Kaur

Thakur

Goswami³

2022

Int J App Pharm

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“…MNs are a minimally invasive transdermal drug delivery system that can form micropores on the skin surface, which can deliver drugs or compounds to specific sites and predetermined depths 25,26 while reducing pain and tissue damage. 27 The transdermal drug delivery system of MNs reduces many of the challenges associated with injectable drug delivery systems. Antibacterial MNs can be used directly as a delivery platform against pathogens.…”

Section: Introductionmentioning

confidence: 99%

Dissolving microneedles based on ZnO nanoparticles and an ionic liquid as synergistic antibacterial agents

et al. 2023

J. Mater. Chem. B

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Collagen‐Based Dissolving Microneedles with Flexible Pedestals: A Transdermal Delivery System for Both Anti‐Aging and Skin Diseases

Gao

Zhou

et al. 2023

Adv Healthcare Materials

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Biocompatible polymer microneedles (MNs) are emerging as a promising platform for transdermal drug delivery, especially for facial treatments. Therefore, an MN patch in this study uses hydrolyzed collagen (HC) contained in skin cells as the main raw material and adopts a two‐step cast method to develop a rapidly dissolving microneedle (DMN) to deliver collagen in a simple and minimally invasive way, allowing the release of the encapsulated drug in the skin. By optimizing the formulation and proportion of HC and auxiliary support materials, the mechanical strength required to pierce the skin is obtained, while the soft pedestal allows for flexibility in application. The DMNs can dissolve completely in the skin within 15 min and release within ≈ 8 h, and do not cause toxicity or irritation when being applied. In contrast to the ineffectiveness of oral and external application, and the high risk of dermal injection, drug‐loaded DMNs overcome the drawbacks of traditional methods with direct penetration and minimally invasive manner, enabling efficient and safe treatment. The successful preparation and research of HC DMNs have innovative and practical significance in this field, and it is expected to become a simple, effective, and popular transdermal drug delivery platform for cosmetics.

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Design and development of insulin microneedles for diabetes treatment

Cited by 23 publications

References 59 publications

Evaluating the Impact of Solid Microneedles on the Transdermal Drug Delivery System for Ɣ-Oryzanol

Evaluating the Impact of Solid Microneedles on the Transdermal Drug Delivery System for Ɣ-Oryzanol

Dissolving microneedles based on ZnO nanoparticles and an ionic liquid as synergistic antibacterial agents

Collagen‐Based Dissolving Microneedles with Flexible Pedestals: A Transdermal Delivery System for Both Anti‐Aging and Skin Diseases

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