Dissolving microneedles based on ZnO nanoparticles and an ionic liquid as synergistic antibacterial agents

Abstract

ZnO NPs had good dispersion in the employed IL, which made the ZnO NPs and the IL exhibit a synergistic antibacterial effect. The DMNs prepared using the ZnO NPs/IL dispersion as an antibacterial agent exhibited a good antibacterial effect.

Porous reticular Co@Fe metal–organic gel: dual–function simulated peroxidase nanozyme for both colorimetric sensing and antibacterial applications

“…The experimental methods were set up referring to previous reports. 38,39 S. aureus with a relatively weak growth activity was used to determine the optimal concentration of H 2 O 2 in the antibacterial experiment. First, 500 μL H 2 O 2 (5–200 mM) was coincubated with an equal volume of S. aureus suspension (10 6 CFU mL −1 ).…”

“…The hemolysis rate was calculated with the following formula:where OD sample , OD negative , and OD positive are the absorbances of the sample, negative control, and positive control group, respectively. 39…”

A multimodal therapy for infected diabetic wounds based on glucose-responsive nanocomposite-integrated microneedles

“…39–41 It is worth noting that hydrogel microneedles and dissolving microneedles are the main types of microneedles that have made great progress in promoting wound healing, and delivery systems based on them are accurate, fast and controllable. 42–44 Hydrogel microneedles with good water absorption and air permeability as wound dressings can protect wounds from bacterial infections. 45,46 Dissolving microneedles can rapidly release drugs to treat wounds.…”