Design and development of Branched Poly(ß-aminoester) nanoparticles for Interleukin-10 gene delivery in a mouse model of atherosclerosis

DiStasio, Nicholas; Dierick, France; Ebrahimian, Talin; Tabrizian, Maryam; Lehoux, Stéphanie

doi:10.1016/j.actbio.2022.02.043

Cited by 10 publications

(3 citation statements)

References 66 publications

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“…modified the VHPK peptide on the surface of poly(β‐aminoester) to construct VHPK NPs that specifically targeted the aortic ECs of mice. [ 178 ] Furthermore, intravenous injections of VHPK NPs in an AS mouse model showed a significant accumulation of the plasmid DNA carried by the NPs within the atherosclerotic plaque sites.…”

Section: Therapeutic Strategies For Asmentioning

confidence: 99%

Recent Advances in Anti‐Atherosclerosis and Potential Therapeutic Targets for Nanomaterial‐Derived Drug Formulations

Xiao,

Li,

Xiong

et al. 2023

Advanced Science

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Atherosclerosis, the leading cause of death worldwide, is responsible for ≈17.6 million deaths globally each year. Most therapeutic drugs for atherosclerosis have low delivery efficiencies and significant side effects, and this has hampered the development of effective treatment strategies. Diversified nanomaterials can improve drug properties and are considered to be key for the development of improved treatment strategies for atherosclerosis. The pathological mechanisms underlying atherosclerosis is summarized, rationally designed nanoparticle‐mediated therapeutic strategies, and potential future therapeutic targets for nanodelivery. The content of this study reveals the potential and challenges of nanoparticle use for the treatment of atherosclerosis and highlights new effective design ideas.

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Section: Therapeutic Strategies For Asmentioning

confidence: 99%

Recent Advances in Anti‐Atherosclerosis and Potential Therapeutic Targets for Nanomaterial‐Derived Drug Formulations

Xiao,

Li,

Xiong

et al. 2023

Advanced Science

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“…More targeted approaches involve protein corona modulation 22,23 and antibody or peptidemediated targeting. 24,25 Surface engineering with antibodies and peptides increases the complexity of the delivery system, limiting clinical translation. [26][27][28] Hence, there is a need for rational functional design of these polymers emerging from the biological identity of the target cell.…”

Section: Introductionmentioning

confidence: 99%

Sugar alcohol-modified polyester nanoparticles for gene delivery via selective caveolae-mediated endocytosis

Reshma G,

Miglani,

Pal

et al. 2024

Nanoscale

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“…[ 24 ] Regarding adverse reactions associated with drugs or surgery, nanomaterials achieve higher drug utilization rates or further enrich the range of surgical options (such as nanodrug‐coated balloons or stents) through elaborated design. [ 25 ] Importantly, nanomaterials provide the ability to integrate diagnosis and treatment for atherosclerosis. In the past, diagnosis and treatment were two separate fields.…”

Section: Introductionmentioning

confidence: 99%

Nanomedicine for Diagnosis and Treatment of Atherosclerosis

Cheng,

Huang,

Chen

et al. 2023

Advanced Science

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With the changing disease spectrum, atherosclerosis has become increasingly prevalent worldwide and the associated diseases have emerged as the leading cause of death. Due to their fascinating physical, chemical, and biological characteristics, nanomaterials are regarded as a promising tool to tackle enormous challenges in medicine. The emerging discipline of nanomedicine has filled a huge application gap in the atherosclerotic field, ushering a new generation of diagnosis and treatment strategies. Herein, based on the essential pathogenic contributors of atherogenesis, as well as the distinct composition/structural characteristics, synthesis strategies, and surface design of nanoplatforms, the three major application branches (nanodiagnosis, nanotherapy, and nanotheranostic) of nanomedicine in atherosclerosis are elaborated. Then, state‐of‐art studies containing a sequence of representative and significant achievements are summarized in detail with an emphasis on the intrinsic interaction/relationship between nanomedicines and atherosclerosis. Particularly, attention is paid to the biosafety of nanomedicines, which aims to pave the way for future clinical translation of this burgeoning field. Finally, this comprehensive review is concluded by proposing unresolved key scientific issues and sharing the vision and expectation for the future, fully elucidating the closed loop from atherogenesis to the application paradigm of nanomedicines for advancing the early achievement of clinical applications.

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Design and development of Branched Poly(ß-aminoester) nanoparticles for Interleukin-10 gene delivery in a mouse model of atherosclerosis

Cited by 10 publications

References 66 publications

Recent Advances in Anti‐Atherosclerosis and Potential Therapeutic Targets for Nanomaterial‐Derived Drug Formulations

Recent Advances in Anti‐Atherosclerosis and Potential Therapeutic Targets for Nanomaterial‐Derived Drug Formulations

Sugar alcohol-modified polyester nanoparticles for gene delivery via selective caveolae-mediated endocytosis

Nanomedicine for Diagnosis and Treatment of Atherosclerosis

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