Design and development of a high resolution animal SPECT scanner dedicated for rat and mouse imaging

Sajedi, Salar; Zeraatkar, Navid; Moji, Vahideh; Farahani, Mohammad Hossein Davood Abadi; Sarkar, Saeed; Arabi, Hossein; Teymoorian, Behnoosh; Ghafarian, Pardis; Rahmim, Arman; Ay, Mohammad Reza

doi:10.1016/j.nima.2014.01.001

Cited by 27 publications

(13 citation statements)

References 26 publications

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“…As expected for parallel-hole collimation, a small decrease is observed when distance is increased [30,31]. The sensitivity decreased sharply when the distance exceeds the size of detector FOV.…”

Section: Discussionsupporting

confidence: 69%

Design and development of a dedicated portable gamma camera system for intra-operative imaging

et al. 2016

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Section: Discussionsupporting

confidence: 69%

Design and development of a dedicated portable gamma camera system for intra-operative imaging

et al. 2016

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“…The HiReSPECT scanner is a newly developed system in our department, Tehran University of Medical Science, which is designed for small‐animal SPECT imaging (Fig. ).…”

Section: Methodsmentioning

confidence: 99%

“…The aim of this study is to develop and evaluate an approach to quantitative SPECT imaging using an iterative reconstruction method along with corrections. Specifically, we aim to improve the quantification accuracy in our dedicated animal SPECT system called HiReSPECT . We have developed a calibration method to determine the activity concentration in MBq/ml, via a system image matrix.…”

Section: Introductionmentioning

confidence: 99%

Implementation of absolute quantification in small‐animal SPECT imaging: Phantom and animal studies

Gerdekoohi

Vosoughi

Tanha

et al. 2017

J Applied Clin Med Phys

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PurposePresence of photon attenuation severely challenges quantitative accuracy in single‐photon emission computed tomography (SPECT) imaging. Subsequently, various attenuation correction methods have been developed to compensate for this degradation. The present study aims to implement an attenuation correction method and then to evaluate quantification accuracy of attenuation correction in small‐animal SPECT imaging.MethodsImages were reconstructed using an iterative reconstruction method based on the maximum‐likelihood expectation maximization (MLEM) algorithm including resolution recovery. This was implemented in our designed dedicated small‐animal SPECT (HiReSPECT) system. For accurate quantification, the voxel values were converted to activity concentration via a calculated calibration factor. An attenuation correction algorithm was developed based on the first‐order Chang's method. Both phantom study and experimental measurements with four rats were used in order to validate the proposed method.ResultsThe phantom experiments showed that the error of −15.5% in the estimation of activity concentration in a uniform region was reduced to +5.1% when attenuation correction was applied. For in vivo studies, the average quantitative error of −22.8 ± 6.3% (ranging from −31.2% to −14.8%) in the uncorrected images was reduced to +3.5 ± 6.7% (ranging from −6.7 to +9.8%) after applying attenuation correction.ConclusionThe results indicate that the proposed attenuation correction algorithm based on the first‐order Chang's method, as implemented in our dedicated small‐animal SPECT system, significantly improves accuracy of the quantitative analysis as well as the absolute quantification.

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“…Pek çok mikroSPECT cihazında pinhole dedektör kullanılmasına rağmen daha büyük görüntü alanı ve yüksek çözünürlük sağlayan paralel kolimatörlü sistemlerin geliştirilmesi için çalışmalar sürmektedir. CsI (Na) kristalinin kullanıldığı bölünmüş dedektör kullanılan çift başlı gama kamera HiReSPECT cihazı bunlardan birisidir (17). Ayrıca kullanılan rekonstrüksiyon metodları da görüntü kalitesi üzerine etkilidir.…”

Section: Mikrospectunclassified

Imaging Modalities Used in Preclinical Studies

Karaçavuş¹

2019

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Öz HangiModalite?Deney hayvanlarının noninvaziv görüntülenmesinde hedeflenen amaçlar doğrultusunda farklı modaliteler kullanılmaktadır. En uygun yöntemin seçilmesinde ilgilenilen parametre yani boyut, fonksiyon, istenilen uzaysal ve temporal rezolüsyon ve sensitivite, dinamik veriye ihtiyaç, tüm vücut/bölgesel veri gerekliliği, çekim süresi, penetrasyon derinliği, kantitatif veriye ihtiyaç, çoklu/tekrarlayan çalışmaya ihtiyaç, birden Imaging modalities have long been indispensable tool in clinical and preclinical practice or drug development. Increasingly, in vivo imaging of small laboratory animals has gained importance as a critical component of preclinical biomedical research as well. The most used modalities for small-animal in vivo imaging applications are based on nuclear medicine techniques (especially, positron emission tomography [PET] and single photon emission computed tomography [SPECT]), computed tomography (CT), and magnetic resonance imaging (MRI). Each modality has intrinsic strengths and limitations, and the choice of the imaging modality depends on the parameter of interest.Recently, aiming to overcome the limitations of each imaging modality, multimodality devices designed to provide complementary information upon the pathophysiological process under study have emerged popularity. The combination of high-resolution modalities, like microCT or microMRI, with highly sensitive techniques providing functional information, such as microPET or microSPECT, will continue to broaden the horizons of research in such areas as infection, oncology, cardiology, and neurology, contributing not only to the understanding of the underlying mechanisms of disease but also providing efficient and unique tools for evaluating new chemical entities and development of candidate drugs. Ya zış maAd re si/Ad dressforCor res pon den ce

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Design and development of a high resolution animal SPECT scanner dedicated for rat and mouse imaging

Cited by 27 publications

References 26 publications

Design and development of a dedicated portable gamma camera system for intra-operative imaging

Design and development of a dedicated portable gamma camera system for intra-operative imaging

Implementation of absolute quantification in small‐animal SPECT imaging: Phantom and animal studies

Imaging Modalities Used in Preclinical Studies

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