Design and development of a dedicated portable gamma camera system for intra-operative imaging

Kaviani, Sanaz; Zeraatkar, Navid; Sajedi, Salar; Akbarzadeh, Afshin; Gorjizadeh, N.; Farahani, Mohammad Hossein Davood Abadi; Teimourian, Behnoosh; Ghafarian, Pardis; Sabet, Hamid; Ay, Mohammad Reza

doi:10.1016/j.ejmp.2016.06.004

Cited by 12 publications

(23 citation statements)

References 33 publications

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“…min min (6) The A min can then be correlated with the minimum required per kilo administered activity of 90 Y, estimated at the time of the intervention 2 :…”

Section: Ht Tummentioning

confidence: 99%

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The β- radio-guided surgery: Method to estimate the minimum injectable activity from ex-vivo test

et al. 2019

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Radio-guided surgery with − β decays is a novel technique under investigation. One of the main advantages is its capability to detect small (⩽ 0.1 ml) samples after injecting the patient with low activity of radiopharmaceutical. This paper presents an experimental method to quantify this feature based on ex-vivo tests on specimens from meningioma patients. Methods: Patients were enrolled on the basis of the standard uptake value (SUV) and the tumour-to-non-tumour activity ratio (TNR) resulted from 68 Ga-DOTATOC PET exams. After injecting the patients with 93-167 MBq of 90 Y-DOTATOC, 26 samples excised during surgery were analyzed with a − β probe. The radioactivity expected on the neoplastic specimens was estimated according to the SUV found in the PET scan and the correlation with the measured counts was studied. The doses to surgeon and medical personnel were also evaluated. Results: Even injecting as low as 1.4 MBq/kg of radiotracer, tumour residuals of 0.1 ml can be detected. A negligible dose to the medical personnel was confirmed. Conclusions: Radio-guided surgery with − β decays is a feasible technique with a low radiation dose for both personnel and patient, in particular if the patient is injected with the minimum required activity. A correlation greater than 80% was observed between the measured counts and the expected activity for the lesion samples based on the individual SUV and the TNR. This makes identifiable the minimum injectable radiotracer activity for cases where 90 Y is the utilized radionuclide. 1. Background Radio-guided surgery (RGS) is a technique aimed at assisting the surgeon to reach as complete a resection of the tumoural lesion as possible, while minimizing the amount of healthy tissue removed[1]. Before surgery, the patient is administered with a specific radio-labeled tracer which is preferentially absorbed by the tumoural tissue. A probe (for a review see [2]), sensitive to the signal emitted by the radio-tracer, is used to identify the radio-marked tumour lesion. As a result, after the bulk removal, RGS provides the surgeon with real-time information

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“…min min (6) The A min can then be correlated with the minimum required per kilo administered activity of 90 Y, estimated at the time of the intervention 2 :…”

Section: Ht Tummentioning

confidence: 99%

“…Established methods to date make use of a γ-emitting tracer and either a γ radiation detecting probe [3,4] or a portable gamma camera [5,6]. Since γ radiation can travel through a large amount of tissue, any uptake of the tracer in nearby healthy tissue represents a non-negligible background, limiting and sometimes preventing the use of this technique.…”

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confidence: 99%

The β- radio-guided surgery: Method to estimate the minimum injectable activity from ex-vivo test

et al. 2019

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“…Medipix2 photon counting readout chip. This imaging probealso adopted in an experimental CT/SPECT system dedicated to the breast [34], and for imaging at nuclear facilities [27,28] could be adopted for various tasks as preoperative or intraoperative SLN localization with 99m Tc radiotracer in breast cancer or melanoma patients [18,[35][36][37][38], breast imaging with 99m Tc-Sestamibi [39], thyroid imaging [40], breast RGS with 125 I and/or 99m Tc radiotracers [41], and in hybrid imaging systems [42]. The same detector unitdeveloped within the Medipix2 Fig.…”

Section: Introductionmentioning

confidence: 99%

“…Comparison of some performance parameters for commercial and experimental compact gamma cameras (adapted from Ref [36]…”

mentioning

confidence: 99%

CdTe compact gamma camera for coded aperture imaging in radioguided surgery

et al. 2020

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“…To date, established methods make use of a γ-emitting tracer and a γ radiation detecting probe [3,4] or a portable gamma camera [5,6]. Since γ radiation can travel through large amounts of tissue, any uptake of the tracer in nearby healthy tissue represents a non-negligible background, strongly limiting and often preventing the use of this technique.…”

mentioning

confidence: 99%

First ex vivo validation of a radioguided surgery technique withβ-radiation.

Camillocci¹,

Schiariti²,

Bocci³

et al. 2016

Physica Medica

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Purpose: A radio-guided surgery technique with β − -emitting radiotracers was suggested to overcome the effect of the large penetration of γ radiation. The feasibility studies in the case of brain tumors and abdominal neuro-endocrine tumors were based on simulations starting from PET images with several underlying assumptions. This paper reports, as proof-of-principle of this technique, an ex-vivo test on a meningioma patient. This test allowed to validate the whole chain, from the evaluation * co-first-author † corresponding author, e-mail: riccardo.faccini@roma1.infn.it Results: we obtained a large signal on the bulk tumor (105 cps) and a significant signal on residuals of ∼0.2 ml (28 cps). We also show that simulations predict correctly the observed yields and this allows us to estimate that the healthy tissues would return negligible signals (≈ 1 cps). This test also demonstrated that the exposure of the medical staff is negligible and that among the biological wastes only urine has a significant activity.Conclusions: This proof-of-principle test on a patient assessed that the technique is feasible with negligible background to medical personnel and confirmed that the expectations obtained with Monte Carlo simulations starting from diagnostic PET images are correct.

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Design and development of a dedicated portable gamma camera system for intra-operative imaging

Cited by 12 publications

References 33 publications

The β- radio-guided surgery: Method to estimate the minimum injectable activity from ex-vivo test

The β- radio-guided surgery: Method to estimate the minimum injectable activity from ex-vivo test

CdTe compact gamma camera for coded aperture imaging in radioguided surgery

First ex vivo validation of a radioguided surgery technique withβ-radiation.

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