Design and development of 5-fluorouracil loaded biodegradable magnetic microspheres as site-specific drug delivery vehicle for cancer therapy

Ayyanaar, Srinivasan; Bhaskar, R.; Esthar, Selvaraj; Vadivel, M.; Rajesh, Jegathalaprathaban; Rajagopal, Gurusamy

doi:10.1016/j.jmmm.2021.168853

Cited by 23 publications

(13 citation statements)

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“… Preparative technique Merits Demerits Application Microsphere-drug combination Ref. Emulsion-solidication Large-scale production, simple operation Wide particle size Oncotherapy Neuralrepair TPP/chitosan/PLGA-NGF Microspheres 5-Fluorouracil loaded biodegradable magnetic Microspheres Polysaccharidebased porous microsphere (PPM) [ 88 , 188 , 189 ] Microfluidics Unique analytical performance, smaller volume, good monodispersity Low production efficiency Oncotherapy 5-Fu loaded CS microspheres [ 30 , 35 ] Mold method Low cost, simple operation Complex synthesis process Protein separation Monodisperse porous silica microspheres [ 58 , 62 , 63 ] Microfluidic electrospray Uniform size and good monodispersity Low production efficiency Skin wounds Novel drug-loaded methacryloyl chondroitin sulfate (CSMA) microspheres [67, 196] Spray drying Simple and stable Limited range of polymers Gastropathy Chitosan-based microspheres [ 75 ] Self-assembly method Simple production technology, mild reaction conditions, and suitability for hydrophilic and hydrophobic drugs Size and monodispersity need to be improved Oncotherapy Paclitaxel-loaded silk fibroin nanospheres [ 78 ] Phase separation method For water-soluble drugs, easy to prepare in batches Difficult to remove organic solvents Arthritis Loaded sPL sustained-release microspheres [ 206 ] Membrane emulsification method...…”

Section: Processing Methods Of Microspheresmentioning

confidence: 99%

“…constructed drug-loaded magnetic microspheres (MMSs) loaded with the anticancer drug 5-fluorouracil (5-FlU), and the results showed that the MMSs ( Fig. 5 A and D) carrying the anticancer drugs could sustainably release the drugs and release the drugs at the target, thus reducing the cytotoxic effects on non-cancer tissues [ 188 ]. In addition, Wu et al.…”

Section: Application Of Microspheres In Diseasesmentioning

confidence: 99%

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Progress in the application of sustained-release drug microspheres in tissue engineering

Ruan¹,

Su²,

Qin³

et al. 2022

Materials Today Bio

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Section: Processing Methods Of Microspheresmentioning

confidence: 99%

Section: Application Of Microspheres In Diseasesmentioning

confidence: 99%

Progress in the application of sustained-release drug microspheres in tissue engineering

Ruan¹,

Su²,

Qin³

et al. 2022

Materials Today Bio

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“…Chemotherapy drug delivery is a process of delivering anticancer drugs to target cancer cells while minimizing the effect on healthy tissues. Chemotherapy drugs can be delivered via a variety of methods, including intravenous injections, oral tablets, transdermal patches, and topical creams [ 187 ]. Traditional chemotherapy drugs are delivered through a systemic approach by administering intravenously and circulating them throughout the body.…”

Section: Cancer Therapymentioning

confidence: 99%

A Review of Advanced Multifunctional Magnetic Nanostructures for Cancer Diagnosis and Therapy Integrated into an Artificial Intelligence Approach

et al. 2023

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The new era of nanomedicine offers significant opportunities for cancer diagnostics and treatment. Magnetic nanoplatforms could be highly effective tools for cancer diagnosis and treatment in the future. Due to their tunable morphologies and superior properties, multifunctional magnetic nanomaterials and their hybrid nanostructures can be designed as specific carriers of drugs, imaging agents, and magnetic theranostics. Multifunctional magnetic nanostructures are promising theranostic agents due to their ability to diagnose and combine therapies. This review provides a comprehensive overview of the development of advanced multifunctional magnetic nanostructures combining magnetic and optical properties, providing photoresponsive magnetic platforms for promising medical applications. Moreover, this review discusses various innovative developments using multifunctional magnetic nanostructures, including drug delivery, cancer treatment, tumor-specific ligands that deliver chemotherapeutics or hormonal agents, magnetic resonance imaging, and tissue engineering. Additionally, artificial intelligence (AI) can be used to optimize material properties in cancer diagnosis and treatment, based on predicted interactions with drugs, cell membranes, vasculature, biological fluid, and the immune system to enhance the effectiveness of therapeutic agents. Furthermore, this review provides an overview of AI approaches used to assess the practical utility of multifunctional magnetic nanostructures for cancer diagnosis and treatment. Finally, the review presents the current knowledge and perspectives on hybrid magnetic systems as cancer treatment tools with AI models.

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“…are administered intravenously, which often leads to a significant number of side effects [ 86 , 87 , 88 , 89 , 90 , 91 ]. The major limitation of present chemotherapeutic agents is the poor selectivity and the resultant toxicity [ 92 ]. Therefore, to minimize the negative effects of anticancer drugs, various systems are being developed for their targeted delivery directly to tumor cells [ 93 ].…”

Section: Synthetic Magnetic Nanoparticlesmentioning

confidence: 99%

Biosensors and Drug Delivery in Oncotheranostics Using Inorganic Synthetic and Biogenic Magnetic Nanoparticles

et al. 2022

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Magnetic nanocarriers have attracted attention in translational oncology due to their ability to be employed both for tumor diagnostics and therapy. This review summarizes data on applications of synthetic and biogenic magnetic nanoparticles (MNPs) in oncological theranostics and related areas. The basics of both types of MNPs including synthesis approaches, structure, and physicochemical properties are discussed. The properties of synthetic MNPs and biogenic MNPs are compared with regard to their antitumor therapeutic efficiency, diagnostic potential, biocompatibility, and cellular toxicity. The comparative analysis demonstrates that both synthetic and biogenic MNPs could be efficiently used for cancer theranostics, including biosensorics and drug delivery. At the same time, reduced toxicity of biogenic particles was noted, which makes them advantageous for in vivo applications, such as drug delivery, or MRI imaging of tumors. Adaptability to surface modification based on natural biochemical processes is also noted, as well as good compatibility with tumor cells and proliferation in them. Advances in the bionanotechnology field should lead to the implementation of MNPs in clinical trials.

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Design and development of 5-fluorouracil loaded biodegradable magnetic microspheres as site-specific drug delivery vehicle for cancer therapy

Cited by 23 publications

References 50 publications

Progress in the application of sustained-release drug microspheres in tissue engineering

Progress in the application of sustained-release drug microspheres in tissue engineering

A Review of Advanced Multifunctional Magnetic Nanostructures for Cancer Diagnosis and Therapy Integrated into an Artificial Intelligence Approach

Biosensors and Drug Delivery in Oncotheranostics Using Inorganic Synthetic and Biogenic Magnetic Nanoparticles

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