Design and characterization of poly(glycerol-sebacate)-co-poly(caprolactone) (PGS-co-PCL) and its nanocomposites as novel biomaterials: The promising candidate for soft tissue engineering

Rostamian, Mostafa; Kalaee, Mohammadreza; Dehkordi, Shiva Raeisi; Panahi‐Sarmad, Mahyar; Tirgar, Mahtab; Goodarzi, Vahabodin

doi:10.1016/j.eurpolymj.2020.109985

Cited by 48 publications

(37 citation statements)

References 77 publications

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“…On average, the water contact angle measurement indicated 118.6 • ± 4.3 for the PGS scaffolds and 112.3 • ± 3.8 for the PGS/HAp scaffolds (Figure 6). The results indicate an increase in hydrophilicity after the addition of Hap, which is consistent with a previously reported study [49]. Multiple articles reported the hydrophilic character of bulk PGS ranging from 32 • [16] to around 70-80 • [49][50][51].…”

Section: Scaffolds Contact Anglesupporting

confidence: 92%

PGS/HAp Microporous Composite Scaffold Obtained in the TIPS-TCL-SL Method: An Innovation for Bone Tissue Engineering

Piszko

Włodarczyk

Zielinska

et al. 2021

IJMS

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In this research, we synthesize and characterize poly(glycerol sebacate) pre-polymer (pPGS) (1H NMR, FTiR, GPC, and TGA). Nano-hydroxyapatite (HAp) is synthesized using the wet precipitation method. Next, the materials are used to prepare a PGS-based composite with a 25 wt.% addition of HAp. Microporous composites are formed by means of thermally induced phase separation (TIPS) followed by thermal cross-linking (TCL) and salt leaching (SL). The manufactured microporous materials (PGS and PGS/HAp) are then subjected to imaging by means of SEM and µCT for the porous structure characterization. DSC, TGA, and water contact angle measurements are used for further evaluation of the materials. To assess the cytocompatibility and biological potential of PGS-based composites, preosteoblasts and differentiated hFOB 1.19 osteoblasts are employed as in vitro models. Apart from the cytocompatibility, the scaffolds supported cell adhesion and were readily populated by the hFOB1.19 preosteoblasts. HAp-facilitated scaffolds displayed osteoconductive properties, supporting the terminal differentiation of osteoblasts as indicated by the production of alkaline phosphatase, osteocalcin and osteopontin. Notably, the PGS/HAp scaffolds induced the production of significant amounts of osteoclastogenic cytokines: IL-1β, IL-6 and TNF-α, which induced scaffold remodeling and promoted the reconstruction of bone tissue. Initial biocompatibility tests showed no signs of adverse effects of PGS-based scaffolds toward adult BALB/c mice.

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Section: Scaffolds Contact Anglesupporting

confidence: 92%

PGS/HAp Microporous Composite Scaffold Obtained in the TIPS-TCL-SL Method: An Innovation for Bone Tissue Engineering

Piszko

Włodarczyk

Zielinska

et al. 2021

IJMS

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“…The storage modulus of PGAZH0.5, however, displayed lower values compared to other samples. The reason could be explained by the poor dispersion of HA nanoparticles within the PGAZH0.5 matrix discussing in Section 3.2, and the low amount of nanoparticles with incomplete filler networks, as reported by the previous study 33 . Loss modulus (E") of the samples are presented in Figure 6(b).…”

Section: Resultsmentioning

confidence: 61%

“…The reason could be explained by the poor dispersion of HA nanoparticles within the PGAZH0.5 matrix discussing in Section 3.2, and the low amount of nanoparticles with incomplete filler networks, as reported by the previous study. 33 Loss modulus (E") of the samples are presented in Figure 6(b). It was observed that the viscose constituent of PGAZ and PGAZH0.5 samples were higher than those of the other samples.…”

Section: Dynamic Mechanical Analysismentioning

confidence: 99%

Green synthesis and characterization of poly(glycerol‐azelaic acid) and its nanocomposites for applications in regenerative medicine

Chenani

Rezaei

Fakhri

et al. 2021

J of Applied Polymer Sci

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A series of novel bio-polyester nanocomposites based on glycerin and azelaic acid as monomers incorporating hydroxyapatite (HA) nanoparticles were fabricated via in situ polymerization method. Chemical structure of the samples was investigated by 1 H-NMR, 13 C-NMR, and Fourier-transform infrared spectroscopy (FTIR). Energy dispersive X-ray-mapping analysis illustrated that the nanoparticles were well dispersed in the poly (glycerol azelaic acid) (PGAZ) matrix. Viscoelastic properties of the samples under various frequencies were examined in which the PGAZ specimen containing 1.0 wt% of HA nanoparticles (PGAZH1.0) exhibited superlative properties. Furthermore, the alterations in the glass transition temperature of the samples were comprehensively discussed. Thermal gravimetric analysis displayed that nanocomposites generally have a difference in degradation patterns from that of the pristine sample. Dynamic contact angle demonstrated that the presence of HA nanoparticles imposed a significant influence on hydrophilicity. The hydrolytic degradation values at pH = 7 and pH = 11 were measured and determined that the degradation rate for the PGAZ sample containing 1.5 wt% HA (PGAZH1.5) was higher than those of the other samples. Moreover, in vitro studies elucidated that cell attachment on PGAZH1.0 and PAZH1.5 surfaces were acceptable.

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“…An alternative approach is a polycondensation of PGSp with linear polymers (Figure 2 Route B), such as PCL [ 63 ] and PEG [ 62,64–67 ] and their acrylated forms, poly(ethylene glycol) methyl ether methacrylate (PEGMEMA), [ 68 ] poly(tetramethylene oxide) glycol (PTMO), [ 69 ] or simply with gelatin. [ 70 ]…”

Section: Modification Of Pgsmentioning

confidence: 99%

“…Rostamian et al. [ 63 ] demonstrated the successful incorporation of hydroxyapatite nanoparticles in PGS‐ co ‐PCL, which was synthesized by melt polycondensation. The authors found a beneficial effect of the addition of caprolactone section in PGS‐ co ‐PCL regarding its viscoelastic properties and wettability.…”

Section: Modification Of Pgsmentioning

confidence: 99%

Poly(Glycerol Sebacate) in Biomedical Applications—A Review of the Recent Literature

Vogt

Ruther

Salehi

et al. 2021

Adv Healthcare Materials

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Poly(glycerol sebacate) (PGS) continues to attract attention for biomedical applications owing to its favorable combination of properties. Conventionally polymerized by a two‐step polycondensation of glycerol and sebacic acid, variations of synthesis parameters, reactant concentrations or by specific chemical modifications, PGS materials can be obtained exhibiting a wide range of physicochemical, mechanical, and morphological properties for a variety of applications. PGS has been extensively used in tissue engineering (TE) of cardiovascular, nerve, cartilage, bone and corneal tissues. Applications of PGS based materials in drug delivery systems and wound healing are also well documented. Research and development in the field of PGS continue to progress, involving mainly the synthesis of modified structures using copolymers, hybrid, and composite materials. Moreover, the production of self‐healing and electroactive materials has been introduced recently. After almost 20 years of research on PGS, previous publications have outlined its synthesis, modification, properties, and biomedical applications, however, a review paper covering the most recent developments in the field is lacking. The present review thus covers comprehensively literature of the last five years on PGS‐based biomaterials and devices focusing on advanced modifications of PGS for applications in medicine and highlighting notable advances of PGS based systems in TE and drug delivery.

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Design and characterization of poly(glycerol-sebacate)-co-poly(caprolactone) (PGS-co-PCL) and its nanocomposites as novel biomaterials: The promising candidate for soft tissue engineering

Cited by 48 publications

References 77 publications

PGS/HAp Microporous Composite Scaffold Obtained in the TIPS-TCL-SL Method: An Innovation for Bone Tissue Engineering

PGS/HAp Microporous Composite Scaffold Obtained in the TIPS-TCL-SL Method: An Innovation for Bone Tissue Engineering

Green synthesis and characterization of poly(glycerol‐azelaic acid) and its nanocomposites for applications in regenerative medicine

Poly(Glycerol Sebacate) in Biomedical Applications—A Review of the Recent Literature

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