Design and baseline characteristics of a coronary heart disease prospective cohort: two-year experience from the strategy of registry of acute coronary syndrome study (ERICO study)

Abstract

OBJECTIVES:To describe the ERICO study (Strategy of Registry of Acute Coronary Syndrome), a prospective cohort to investigate the epidemiology of acute coronary syndrome.METHODS:The ERICO study, which is being performed at a secondary general hospital in Sao Paulo, Brazil, is enrolling consecutive acute coronary syndrome patients who are 35 years old or older. The sociodemographic information, medical assessments, treatment data and blood samples are collected at admission. After 30 days, the medical history is updated, and additional blood and urinary samples are collected. In addition, a retinography, carotid intima-media thickness, heart rate variability and pulse-wave velocity are performed. Questionnaires about food frequency, physical activity, sleep apnea and depression are also applied. At six months and annually after an acute event, information is collected by telephone.RESULTS:From February 2009 to September 2011, 738 patients with a diagnosis of an acute coronary syndrome were enrolled. Of these, 208 (28.2%) had ST-elevation myocardial infarction (STEMI), 288 (39.0%) had non-ST-elevation myocardial infarction (NSTEMI) and 242 (32.8%) had unstable angina (UA). The mean age was 62.7 years, 58.5% were men and 77.4% had 8 years or less of education. The most common cardiovascular risk factors were hypertension (76%) and sedentarism (73.4%). Only 29.2% had a prior history of coronary heart disease. Compared with the ST-elevation myocardial infarction subgroup, the unstable angina and non-ST-elevation myocardial infarction patients had higher frequencies of hypertension, diabetes, prior coronary heart disease (p<0.001) and dyslipidemia (p = 0.03). Smoking was more frequent in the ST-elevation myocardial infarction patients (p = 0.006).CONCLUSIONS:Compared with other hospital registries, our findings revealed a higher burden of CV risk factors and less frequent prior CHD history.

Cardiovascular diseases in Brazil: premature mortality, risk factors and priorities for action. Comments on the preliminary results from the Brazilian National Health Survey (PNS), 2013

“…7 Case-fatality rates are easier to obtain from the organized hospital-based registries that have been created in Brazil. [8][9][10] These registries are helpful in determining the levels of pre-hospital care, compliance with guidelines among the medical team and, especially, quality of procedures such as thrombolytic therapy, angioplasty and coronary revascularization. In addition, data on the adherence among In contrast, the proportion of diabetics receiving drugs free of charge was significantly different from the proportion of individuals with hypertension.…”

Time-To-Treatment of Acute Coronary Syndrome and First Contact in the ERICO Study

“…14-17 Briefly, ERICO is a prospective observational study of 1,085 individuals admitted to a HU-USP because of an ACS event between February 2009 and December 2013. This is a community hospital in Butantã, a neighborhood in São Paulo, Brazil with an area of 12.5 km 2 , an estimated population of 428,000 inhabitants in 2010, and marked socioeconomic inequalities.…”

“…14 The main objective of the present analysis was to investigate if the unit of first contact influenced the frequency and time to aspirin treatment in the ERICO study. Our secondary objectives were to investigate if the unit of first contact influenced the times to heparin, clopidogrel and thrombolytic treatments.…”

Prognostic value of carotid intima‐media in the short‐ and long‐term mortality in the Strategy of Registry of Acute Coronary Syndrome (ERICO) study

“…34,36 ERICO participants must fulfill diagnostic criteria for ST elevation myocardial infarction (STEMI), nonST elevation myocardial infarction (NSTEMI) or unstable angina (UA); the criteria used to define acute coronary syndromes were: 34,36 ERICO participants must fulfill diagnostic criteria for ST elevation myocardial infarction (STEMI), nonST elevation myocardial infarction (NSTEMI) or unstable angina (UA); the criteria used to define acute coronary syndromes were:…”

“…32,33 Thus, we decided to evaluate the prognostic value of CIMT in all-cause, CVD and CHD mortality during 3-year follow-up in participants who survived an ACS event from a prospective cohort, the Strategy of Registry of Acute Coronary Syndrome (ERICO) study, a community-based cohort located in a low socioeconomic area in city of São Paulo, Brasil. 34…”