Design and analysis of capacitance based Bio-MEMS cantilever sensor for tuberculosis detection

Saeed, Muhammad; Khan, Shahbaz; Ahmed, Nisar; Khan, M. Adam; Rehman, Adil

doi:10.1109/intelse.2016.7475116

Cited by 18 publications

(7 citation statements)

References 9 publications

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“…The surface force range for binding of antigen antibody are 10N to 100N and the intermolecular force produced by binding of single antigen antibody is 10N (17). Thus interactions of 10 antigen antibody are measured and force of intermolecular is consider and is applied on the cantilever surface and its deformation value is demonstrated.…”

Section: Micro Cantilever Biosensormentioning

confidence: 99%

Design and Exploration of Micro Cantilever Biosensor for Detection of Tuberculosis

Thorat¹,

Jadhav²

2022

ECS Trans.

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According to the WHO, health is a circumstances of personal resources. There is a necessity to prevent health related issues by diagnosing the disease within time. Number of hazardous diseases are there which are not able to catch within time. Globally from top ten diseases, one of the leading cause of death is tuberculosis. Due to the complicated structure, diagnose the bacteria of tuberculosis is very tedious job. Its an airborne disease. So there is a huge requirement to build a technique which can detect tuberculosis easily and at an early stage. The purpose of the paper is to study, design, and simulate the cantilever biosensor for quick detection of tuberculosis. Micro cantilever biosensor are designed with different dimensions and shapes. The surface of micro cantilever biosensor are prepared with various materials and are coated with antibodies. The sample of patient is placed on to the cantilever, if sample is infected with tuberculosis then antibodies get binds with antigens and it generate stress on the surface and it delivers displacement. Displacement of various designs of micro cantilever were analyzed and maximum displacement were recorded. Rectangle shape with gold material of micro cantilever biosensor achieved maximum displacement as 1.71 x 1028 µm for a load of 100N.

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Section: Micro Cantilever Biosensormentioning

confidence: 99%

Design and Exploration of Micro Cantilever Biosensor for Detection of Tuberculosis

Thorat¹,

Jadhav²

2022

ECS Trans.

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“…Therefore, the design of biosensors requires a wide range of scientific and technical knowledge such as biochemistry, solid-state physics, surface chemistry, electrical engineering, etc . Recently, advances in micromachining and nanotechnology have made it possible to integrate the biosensing film, transducer, and partial readout system into a single device, enabling the fabrication of small and low-cost micro/nanoelectromechanical system (MEMS/NEMS) biosensors for continuous and in situ monitoring of the analyte of interest, even at trace levels. , The transducer of MEMS/NEMS biosensors is commonly a movable mechanical part such as a cantilever, a double-sided fixed beam, or a membrane that is deflected upon the occurrence of a recognition event at the biosensing film . The sensing mechanism of such movable transducers works in two different modes including static and dynamic modes.…”

Section: Introductionmentioning

confidence: 99%

Membrane-Based NEMS/MEMS Biosensors

Stapf,

Selbmann,

Joseph

et al. 2024

ACS Appl. Electron. Mater.

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Membrane-based nano/microelectromechanical system (NEMS/MEMS) biosensors offer sustainable, costeffective, ultraminiaturized and easy-to-use analytical techniques for various applications, especially in the environmental and biomedical/pharmaceutical fields. Compared to cantilever-based MEMS/NEMS biosensors, membrane-based MEMS/NEMS biosensors have higher sensitivity, especially for liquid samples, as the back of the membrane is not in contact with the analyte solution, resulting in a higher signal-to-noise ratio. This review provides deep insight into the fundamentals, membrane materials, different biosensing designs, as well as various transducers used in membrane-based MEMS/NEMS biosensors. The performance of the developed membrane-based MEMS/NEMS biosensors is critically discussed, and their trends and challenges are highlighted. Among the reported biosensors, capacitive-based surface stress biosensors and capacitive micromachined ultrasonic transducer (CMUT) biosensors are emerging as sophisticated and sensitive platforms for biosensing with the ability to detect multiple targets simultaneously. Nevertheless, challenges remain in biosensor design, parameter optimization, and selection of appropriate membrane materials. Further research is imperative to improve the capabilities of these biosensors, particularly in advancing array technologies for the simultaneous detection of multiple analytes.

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“…Rapid advancement in MEMS technology has led to the development of various BioMEMS sensors for detection and diagnosis of a plethora of diseases for healthcare at a faster rate with improved sensitivity and accuracy which is very much required at the present situation of COVID-19 pandemic [1][2][3]. Among the most popular types of such miniaturized sensors, suspended polymeric microstructures such as microcantilevers and microbeams have several advantages including low cost, low analyte requirement, high sensitivity and faster response times compared to others [4][5][6].…”

Section: Introductionmentioning

confidence: 99%

“…Among the most popular types of such miniaturized sensors, suspended polymeric microstructures such as microcantilevers and microbeams have several advantages including low cost, low analyte requirement, high sensitivity and faster response times compared to others [4][5][6]. Development of these sensors have been explored significantly since they have simple mechanical behavior which translates mechanical forces into displacement that have successfully detected various analyte species like, enzymes, antigens, antibodies, and biochemical substances through gravimetric analysis [3,4,7,8]. Further, the target analytes can be easily detected using various mechanisms like optical deflection, capacitance change, piezoresistive change, resonance frequency shift etc [7][8][9][10].…”

Section: Introductionmentioning

confidence: 99%

Simulation and Design Optimization of Polymeric Micro-Structures based Bio-Sensors

Balasundaram

Raghunathan

Hemavathy

et al. 2021

2021 2nd Global Conference for Advancement in Technology (GCAT)

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Suspended polymeric microstructures in the form of microcantilevers and microbeams have seen enormous flux of usage in physical, chemical and biological sensing. Present work investigates more about miniaturized PDMS elastomeric microbeams which can overcome the drawback of conventional rigid silicon based micro-sensors. Static and dynamic methods of analysis for the as-fabricated structures in the lab have been investigated in the present study using COMSOL Multiphysics® 5.3 software to give a better insight about its sensitivity. The study was compared with that of conventional polysilicon microbeams of similar dimensions also and proved to be less effective that polymeric ones. Further, the static and dynamic analysis of the microbeams revealed that the sensors were capable of detecting a minimum mass of almost 70 μg and 50 pg respectively, suggesting that the dynamic analysis provided sensitivity than static method.

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Design and analysis of capacitance based Bio-MEMS cantilever sensor for tuberculosis detection

Cited by 18 publications

References 9 publications

Design and Exploration of Micro Cantilever Biosensor for Detection of Tuberculosis

Design and Exploration of Micro Cantilever Biosensor for Detection of Tuberculosis

Membrane-Based NEMS/MEMS Biosensors

Simulation and Design Optimization of Polymeric Micro-Structures based Bio-Sensors

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