Zoonosis is a class of diseases that specifically originates in the animals. Pakistan is particularly susceptible to zoonotic illnesses because of its varied environment, large-scale cattle husbandry, and intimate relationships between humans and animals. This chapter looks at the epidemiology, clinical presentation, and public health consequences of various zoonotic diseases that are of high priority in Pakistan: anthrax, Avian Influenza, brucellosis, rabies, Salmonella infections, tuberculosis, Crimean-Congo hemorrhagic fever (CCHF) and Leishmaniasis. The complex interactions between humans, animals, and the environment that contribute to the appearance, spread, and transmission of various illnesses sign and symptoms, economic importance and possible remedies of the aforesaid diseases and infections. The text draws attention to the difficulties Pakistan has in managing zoonotic illnesses, which include inadequate resources, insufficient knowledge, and subpar surveillance systems. Additionally, the chapter offers a number of intervention techniques, highlighting the necessity of multi-sectoral cooperation and the advancement of One Health programs. Improved public awareness campaigns, immunization campaigns, better animal husbandry techniques, better veterinarian services, and better disease tracking and reporting are some of these tactics. In Pakistan a significant number of human and animal population are susceptible to these diseases. As these diseases have the competency to spread from the infected animals through skin contact and body fluids which is most of the time lethal, Pakistan may guarantee the health and safety of its populace while considerably lowering the burden of zoonotic illnesses by tackling these issues and putting into practice efficient treatments. However, some common traits include the capacity to spread by contact with sick animals or their products, the capacity to produce a range of symptoms in both humans and animals, and the capacity to be lethal. It's crucial to be informed about the zoonotic diseases that are common in Pakistan and to take precautions against them.