Descriptive Epidemiology of COVID-19 Deaths during the First Wave of Pandemic in India: A Single-center Experience

Tendulkar, Prakash; Pandey, Pragya; Panda, Prasan Kumar; Bhadoria, Ajeet Singh; Kulshreshtha, Poorvi

doi:10.5005/jp-journals-10071-24085

Cited by 4 publications

(3 citation statements)

References 21 publications

(21 reference statements)

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“…In contrast to the first wave, fewer patients underwent renal replacement therapy during the second wave. This may be attributed to the rapid progression of the disease and short hospital stays [4]. Acute respiratory distress syndrome remains the leading cause of death in COVID-19 patients, as seen in multiple studies and meta-analyses, including the present study [12,25].…”

Section: Figure 3: Trend Of Covid-19 Cases In India (Authors Prepared...mentioning

confidence: 59%

“…The male preponderance of mortality was evident in both waves. The median number of days between the onset of symptoms and hospital admission was six (3)(4)(5)(6)(7)(8)(9)(10)(11) days in the second wave, which is significantly different from the corresponding interval in the first wave (p<0.001). The median duration of hospital stay was five (3-10) days in the second wave, which is significantly different from the corresponding time in the first wave (p<0.001).…”

Section: Resultsmentioning

confidence: 77%

“…A descriptive study is already done at the same center to assess the first wave's comorbidities, risk factors, clinical signs and symptoms, and other baseline characteristics [4]. The present study is aimed at looking for differences in baseline characteristics between the first and second waves at a tertiary care hospital in Uttarakhand, India.…”

Section: Introductionmentioning

confidence: 99%

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Comparative Study Between the First and Second Wave of COVID-19 Deaths in India: A Single Center Study

Tendulkar¹,

Pandey²,

Panda³

et al. 2023

Cureus

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The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is continuously evolving, and many mutant variants of the virus are circulating in the world. Recurrent waves of COVID-19 have caused enormous mortality all across the globe. Considering the novelty of the virus, it becomes crucial for healthcare experts and policymakers to understand the demographic and clinical attributes of inpatient deaths in the first and second waves of COVID-19. MethodsThis hospital record-based comparative study was conducted at a tertiary care hospital in Uttarakhand, India. The study included all COVID-19 RT PCR-positive patients admitted to the hospital during the first wave, from 1 st April 2020 to 31 st January 2021, and the second wave from 1 st March 2021 to 30 th June 2021. Comparisons were made with respect to demographic, clinical, laboratory parameters, and course of hospital stay. ResultsThe study exhibited 11.34% more casualties in the second wave, with the number of deaths being 424 and 475 for the first and second waves, respectively. A male preponderance of mortality was evident in both waves with significant differences (p=0.004). There was no significant difference in age between the two waves (p=0.809). The significantly different comorbidities were hypertension (p=0.003) and coronary artery disease (p=0.014). The clinical manifestations demonstrating a significant difference were cough (p=0.000), sore throat (p=0.002), altered mental status (p=0.002), headache (p=0.025), loss of taste and smell (p=0.001), and tachypnea (p=0.000). The lab parameters with a significant difference across both waves were lymphopenia (p=0.000), elevated aspartate aminotransferase (p=0.004), leukocytosis (p=0.008), and thrombocytopenia (p=0.004). During the hospital course of the second wave, in terms of intensive care unit stay, the need for non-invasive ventilation and inotrope support was higher. The complications manifesting in the form of acute respiratory distress syndrome and sepsis were observed more in the second wave. A significant difference was discerned in the median duration of hospital stay in both waves (p=0.000). ConclusionDespite being of shorter duration, the second wave of COVID-19 culminated in more deaths. The study demonstrated that most of the baseline demographic and clinical characteristics attributed to mortality were more common during the second wave of COVID-19, including lab parameters, complications, and duration of hospital stays. The unpredictable nature of COVID-19 waves calls for instituting a well-planned surveillance mechanism in place to identify the surge in cases at the earliest possible time and prompt response, along with developing infrastructure and capacity to manage complications.

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Section: Figure 3: Trend Of Covid-19 Cases In India (Authors Prepared...mentioning

confidence: 59%

Section: Resultsmentioning

confidence: 77%

Section: Introductionmentioning

confidence: 99%

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Comparative Study Between the First and Second Wave of COVID-19 Deaths in India: A Single Center Study

Tendulkar¹,

Pandey²,

Panda³

et al. 2023

Cureus

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Isolation and Characterization of Five Severe Acute Respiratory Syndrome Coronavirus 2 Strains of Different Clades and Lineages Circulating in Eastern India

Singh

Avula²,

Chatterjee³

et al. 2022

Front. Microbiol.

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The emergence of the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) as a serious pandemic has altered the global socioeconomic dynamics. The wide prevalence, high death counts, and rapid emergence of new variants urge for the establishment of research infrastructure to facilitate the rapid development of efficient therapeutic modalities and preventive measures. In agreement with this, SARS-CoV-2 strains were isolated from patient swab samples collected during the first COVID-19 wave in Odisha, India. The viral isolates were adapted to in vitro cultures and further characterized to identify strain-specific variations in viral growth characteristics. The neutralization susceptibility of viral isolates to vaccine-induced antibodies was determined using sera from individuals vaccinated in the Government-run vaccine drive in India. The major goal was to isolate and adapt SARS-CoV-2 viruses in cell culture with minimum modifications to facilitate research activities involved in the understanding of the molecular virology, host–virus interactions, drug discovery, and animal challenge models that eventually contribute toward the development of reliable therapeutics.

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Multisystem Inflammatory Syndrome in Adult Following COVID-19 Vaccination (MIS-AV)

Ganapathiram¹,

Hudson²

2022

Indian Journal of Critical Care Medicine

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Descriptive Epidemiology of COVID-19 Deaths during the First Wave of Pandemic in India: A Single-center Experience

Cited by 4 publications

References 21 publications

Comparative Study Between the First and Second Wave of COVID-19 Deaths in India: A Single Center Study

Comparative Study Between the First and Second Wave of COVID-19 Deaths in India: A Single Center Study

Isolation and Characterization of Five Severe Acute Respiratory Syndrome Coronavirus 2 Strains of Different Clades and Lineages Circulating in Eastern India

Multisystem Inflammatory Syndrome in Adult Following COVID-19 Vaccination (MIS-AV)

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